Robert "Oz" Ossiboff
Current Position: Postdoc with the Wildlife Health Group, Animal Health Diagnostic Center with Dr. Elizabeth Bunting
Oz is originally from Bridgeton, NJ. He spent one year at Wake Forest University before transferring to Loyola University in Chicago. His extracurricular interests include fishing, herpetology, football, and the outdoors.
DVM, Cornell University, 2010
Feline Calicivirus (FCV) is a common feline pathogen, responsible for up to 50% of all cases of feline upper respiratory tract disease. It is typically characterized by high morbidity and low mortality. Recently however, multiple outbreaks of unusually virulent FCV - termed Virulent Systemic Feline Calicivirus (VS-FCV) have occurred that cause both high morbidity and high mortality (up to 60%). My research project is focused on elucidating some of the molecular mechanisms responsible for the changes in virulence and tissue tropism between wild type FCV and VS-FCV through analysis of in vitro viral properties of FCV isolates and receptor binding, as well as structural and mutagenesis studies.
Publications & Presentations
Longo AV, Ossiboff RJ, Zamudio KR, Burrowes PA. Lability in host defences: terrestrial frogs die from chytridiomycosis under enzootic conditions. J Wildl Dis. 2013 Jan;49(1):197-0. doi: 10.7589/2012-05-129.
Ossiboff RJ, Zhou Y, Lightfoot PJ, Prasad BV, Parker JS. Confromational changes in the capsid of a calicivirus upon interaction with its functional receptor. J Virol. 2010 Jun;84(11):5550-64. doi: 10.1128/JVI.02371-09. Epub 2010 Mar 21. PMID: 20357100
Pesavento P, Liu H, Ossiboff RJ, Stucker KM, Heymer A, Millon L, Wood J, van der List D, Parker JS. Characterization of a continuous feline mammary epithelial cell line susceptible to feline epitheliotropic viruses. J Virol methods. 2009 Apr;157(1):105-10. doi: 10.1016/j.jviromet.2008.11.018.Epub 2009 Jan 14. PMID: 19103225
Ossiboff, R. J., A. Sheh, J. Shotton, P. A. Pesavento, and J. S. Parker. 2007. Feline caliciviruses (FCVs) isolated from cats with virulent systemic disease possess in vitro phenotypes distinct from those of other FCV isolates. J Gen Virol 88:506-27.
Ossiboff, R. J., and J. S. Parker. 2007. Identification of regions and residues in feline junctional adhesion molecule required for feline calicivirus binding and infection. J Virol 81:13608-21.
2005 - American Society for Virology Annual Meeting, Oral presentation: "Characterization of in vitro differences between high and low virulence isolates of feline calicivirus," Robert Ossiboff, Alexander Sheh, Christian Nelson, Colin Parrish, John Parker
2006 - American Society for Virology Annual Meeting, Oral presentation: "Characterization of the in vitro growth kinetics and stability of feline calicivirus isolates," Robert Ossiboff, John Parker
2007 - Gordon Conference, Viruses and Cells, Poster: "The amino terminal D1 domain of feline junctional adhesion molecule A (fJAM-A) is necessary and sufficient for the binding of feline calicivirus (FCV)," Robert Ossiboff, John Parker
2007 - American Society for Virology Annual Meeting, Oral presentation: "The amino terminal D1 domain of feline junctional adhesion molecule A (fJAM-A) is necessary and sufficient for the binding of feline calicivirus (FCV)," Robert Ossiboff, John Parker
2007 - 3rd International Calicivirus Conference, Oral presentation: "Identification of regions and residues in feline junctional adhesion molecule A (fJAM-A) required for feline calicivirus (FCV) binding and infection," Robert Ossiboff, John Parker