Anne (Gordon) Schneider
Anne has grown up in NY, MA, and DE, the latter where her family currently resides. She attended Elizabethtown College in Elizabethtown, PA where she pursued a major in biology. Anne was initially interested in entering veterinary school, but while at Elizabethtown she worked on a research project that encouraged her to pursue both degrees. She is currently enrolled in her third year of the Combined DVM/PhD program at Cornell.
Anne's extracurricular activities include volunteering at Cornell's Wildlife Center, serving as a curriculum committee student representative for the class of 2011, participation in various vet school clubs, as well as being a member of Ultrasound, the vet school acapella group. She also enjoys hiking, swing dancing, singing/karaoke, and spending time with her wonderful fiancée, to whom she will be married in August of 2008.
B.S., Elizabethtown College, Elizabethtown, PA.
In general, my PhD research focuses on how a protozoan of medical importance, Toxoplasma gondii, interacts with the host's immune system using the mouse as a model. More specifically, I am examining in detail how T. gondii infection affects a common cytokine signaling pathway known as the JAK/STAT1 pathway in dendritic cells. STAT1 is a transcription factor that activates a number of genes involved in antimicrobial effector functions in innate immune cells. I have found that this parasite can induce STAT1 phosphorylation and nuclear translocation of phosphorylated STAT1 upon infection in the absence of any additional cytokine. Additionally, this phosphorylation event requires active infection to occur and be maintained over time. I plan to examine the mechanism of this parasite-induced STAT1 phosphorylation in more detail, and have already found a role for host upstream JAKs in this process. In addition, experiments are in progress to assess the function of the phosphorylated STAT1. I am also examining strains of three different clonal lineages of the parasite to see if any differences arise that could explain variation in virulence characteristics.
Publications and Presentations