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Zhu L, Zhang Z, Schweitzer P, Phavaphutanon J, Vernier-Singer M, Corey E, Friedenberg S, Mateescu R, Williams A, Lust G, Acland G, Todhunter R. Refined quantitative trait loci intervals for hip joint laxity in dogs. Anim Genetics, 39(2):141-6, 2008.
PubMed abstract
Winegardner KR, Scrivani PV, Krotscheck U, Todhunter RJ. Magnetic resonance imaging of subarticular bone marrow lesions in dogs with stifle lameness. Vet Radiol Ultrasound 48(4):312-317, 2007.
PubMed abstract
Liu T, Todhunter RJ, Wu S, Hou W, Mateescu R, Zhang Z, Burton-Wurster NI, Acland GM, Lust G, Wu R. A random model for mapping imprinted quantitative trait loci in a structured pedigree: an implication for mapping canine hip dysplasia. Genomics 90(2):276-284, 2007.
PubMed abstract
Kerns JA, Cargill EJ, Clark LA, Candille SI, Berryere TG, Olivier M, Lust G, Todhunter RJ, Schmutz SM, Murphy KE, Barsh GS. Linkage and segregation analysis of black and brindle coat color in domestic dogs. Genetics 176(7):1-11, 2007.
PubMed abstract
Zhang Z, Todhunter RJ, Buckler ES, Van Vleck LD: Technical note: use of marker-based relationships with multiple-trait derivative-free restricted maximal likelihood. J Anim Sci 85(4):881-885, 2007.
PubMed abstract
Hays L, Zhang Z, Mateescu RG, Lust G, Burton-Wurster NI, Todhunter RJ: Quantitative genetics of secondary hip joint osteoarthritis in a Labrador Retriever-Greyhound pedigree. Am J Vet Res 68(1):35-41, 2007.
PubMed abstract
Watts AE, Fubini SL, Vernier-Singer M, Golkowski C, Shin S, Todhunter RJ: In vitro analysis of nonthermal plasma as a disinfecting agent. Am J Vet Res 67(12):2030-2035, 2006.
Thoesen MS, vandenBerg-Foels WS, Stokol T, Rassnick KM, Jacobson MS, Kevy SV, Todhunter RJ: Use of a centrifugation-based point-of-care device for production of canine autologous bone marrow and platelet concentrations. Am J Vet Res 67(10):1655-1661, 2006.
PubMed abstract
vandenBerg-Foels WS, Todhunter RJ, Schwager SJ, Reeves AP: Effect of early postnatal body weight on femoral head ossification onset and hip osteoarthritis in a canine model of developmental dysplasia of the hip. Pediatr Res 60(5):549-554, 2006.
PubMed abstract
Chalmers HJ, Dykes NL, Lust G, Farese JP, Burton-Wurster NI, Williams AJ, Todhunter RJ: Assessment of bone mineral density of the femoral head in dogs with early osteoarthritis. Am J Vet Res 67(5):796-800, 2005.
PubMed abstract
Todhunter RJ, Mateescu R, Lust G, Burton-Wurster NI, Dykes NL, Bliss SP, Williams AJ, Vernier-Singer M, Corey E, Harjes C, Quaas RL, Zhang Z, Gilbert RO, Volkmann D, Casella G, Wu R, Acland GM: Quantitative trait loci for hip dysplasia in a crossbreed pedigree. Mamm Genome 16(9):720-730, 2005.
PubMed abstract
Todhunter RJ, Mateescu RG, Zhang Z, Dykes NL, Burton-Wurster NI, Lust G. Diagnosis and genetic loci mapping for canine hip dysplasia. Veterinary Forum 22(8):39-44, 2005.
Mateescu RG, Zhang Z, Tsai K, Phavaphutanon J, Burton-Wurster NI, Lust G, Quaas R, Murphy K, Acland GM, Todhunter, RJ: Analysis of allele fidelity, polymorphic information content, and density of microsatellites in a genome-wide screening for hip dysplasia in a crossbreed pedigree. J Hered 96(7):847-853, 2005.
PubMed abstract
Burton-Wurster N, Mateescu RG, Todhunter RJ, Clements KM, Sun Q, Scarpino V, Lust G: Genes in canine articular cartilage that respond to mechanical injury: gene expression studies with Affymetrix canine GeneChip. J Hered 96(7):821-838, 2005.
PubMed abstract
Aguila AZ, Manos JM, Orlansky AS, Todhunter RJ, Trotter EJ, van der Meulen MCH: In vitro biomechanical comparison of limited contact dynamic compression plate and locking compression plate. Vet Comp Orthop Traumatol 18(4):220-226, 2005.
Mateescu R, Todhunter RJ, Lust G, Burton-Wurster N: Increased MIG-6 mRNA transcripts in osteoarthritic cartilage. Biochem Biophys Res Commun 332(2):482-486, 2005.
PubMed abstract
Xiang-Yang L, Casella G, Todhunter RJ, Wu R: A general statistical framework for unifying interval and linkage disequilibrium mapping: towards high-resolution mapping of quantitative traits. J Am Stat Assoc 100:158-71, 2005.
Steffey MA, Miura N, Todhunter RJ, Nykamp SG, Freeman KP, Scarpino V, Vernier-Singer MA, Erb HN, MacLeod JN, Lust G, Burton-Wurster N: The potential and limitations of cartilage-specific (V+C)(-) fibronectin and cartilage oligomeric matrix protein as osteoarthritis biomarkers in canine synovial fluid. Osteoarthritis Cartilage 12(10):818-825, 2004.
PubMed abstract
Todhunter RJ, Bliss SP, Casella G, Wu R, Lust G, Burton-Wurster NI, Williams AJ, Gilbert RO, Acland G. Genetic structure of susceptibility traits for hip dysplasia and microsatellite informativeness of an outcrossed canine pedigree. J Hered 94(1); 39-48, 2003.
Todhunter RJ, Casella G, Bliss SP, Lust G, Williams AJ, Hamilton S, Dykes NL, Yeager A, Gilbert RO, Burton-Wurster N, Mellersh CC, Acland GM. Power of a dysplastic Labrador Retriever-Greyhound pedigree for linkage analysis of hip dysplasia. Am J Vet Res 64: 418-424, 2003.
Todhunter RJ, Bertram JE, Smith S, et al. Effect of dorsal hip loading, sedation, and general anesthesia on dorsolateral subluxation score in dogs. Vet Surgery 32(3): 196-205, 2003.
PubMed abstract
Todhunter RJ, Grohn YT, Bliss SP, Wilfand A, Williams AJ, Vernier-Singer M, Burton-Wurster N, Dykes NL, Wu R, Casella G, Acland GM, Lust G: Evaluation of multiple radiographic predictors of cartilage lesions in the hip joints of 8-month-old dogs. Am J Vet Res 64:1472-1478, 2003.
PubMed abstract
Mertens WD, Macleod JN, Fubini SL, Vernier-Singer M, Nixon AJ, Todhunter RJ: Polysulfated glycosaminoglycans modulate transcription of interleukin-treated chondrocytes in monolayer culture. Vet Comp Orthop Traumatol 2: 93-98, 2003.
Kennedy S, Lee DV, Bertram JEA, Bliss SP, Williams AJ, Soderholm V, Lust GL, Todhunter RJ: Analysis of ground reaction forces from serial force platforms in dogs with normal and osteoarthritic hips. Vet Comp Orthop Traumatol 16:170-177, 2003.
Todhunter RJ, Bliss SP, Casella G, Wu R, Lust G, Burton-Wurster NI, Williams AJ, Gilbert RO, Acland G. Genetic structure of susceptibility traits for hip dysplasia and microsatellite informativeness of an outcrossed canine pedigree. J Hered 94:39-48, 2003.
PubMed abstract
Todhunter RJ, Casella G, Bliss SP, Lust G, Williams AJ, Hamilton S, Dykes NL, Yeager A, Gilbert RO, Burton-Wurster N, Mellersh CC, Acland GM. Power of a dysplastic Labrador Retriever-Greyhound pedigree for linkage analysis of hip dysplasia. Am J Vet Res 64:418-424, 2003.
PubMed abstract
Lou X-Y, Todhunter RJ, Lin M, Lu Q, Liu T, Bliss SP, Casella G, Acland GM, Lust G, Wu R. The extent and distribution of linkage disequilibrium in canine. Mamm Gen. Aug;14(8):555-64, 2003.
PubMed abstract
Bliss S, Todhunter RJ, Quaas R, Casella G, Wu R, Lust G, Williams AJ, et al. Quantitative genetics of traits associated with canine hip dysplasia in a canine pedigree constructed by mating dysplastic Labrador Retrievers and unaffected Greyhounds. Am J Vet Res 63:1029-1035, 2002.
PubMed abstract
Lust G, Todhunter RJ, Erb HN, Dykes NL, Williams AJ, Burton-Wurster NI, Farese JP: Comparison of three radiographic methods for diagnosis of hip dysplasia in eight-month-old dogs. J Am Vet Med Assoc 219(9):1242-1246, 2001.
PubMed abstract
Lust G, Todhunter R.J, Erb HN, Dykes NL, Williams AJ, Burton-Wurster NI, Farese JP: Repeatability of dorsolateral subluxation scores in dogs and correlation with macroscopic appearance of hip osteoarthritis. Am J Vet Res 62(11):1711-1715, 2001.
PubMed abstract
Fubini SL, Todhunter RJ, Burton-Wurster N, Vernier-Singer M, MacLeod JN. Corticosteroids alter the differentiated phenotype of articular chondrocytes. J Orthop Res 19(4):688-695, 2001.
PubMed abstract
Murphy DJ, Todhunter RJ, Fubini SL, Vernier-Singer M, Straubinger RK, Lust G: The effects of methylprednisolone on normal and monocyte-conditioned medium-treated articular cartilage from dogs and horses. Vet Surg 29(6):546-557, 2000.
PubMed abstract
Sevalla K, Todhunter RJ, Vernier-Singer M, Budsberg SC: Effect of polysulfated glycosaminoglycan on DNA content and proteoglycan metabolism in normal and osteoarthritic canine articular cartilage explants. Vet Surg 29(5):407-414, 2000.
PubMed abstract
Bertram JE, Lee DV, Case HN, Todhunter RJ: Comparison of the trotting gaits of Labrador Retrievers and Greyhounds. Am J Vet Res 61(7):832-838, 2000.
PubMed abstract
Todhunter RJ, Acland GM, Olivier M, et al: An outcrossed canine pedigree for linkage analysis of hip dysplasia. J Heredity 90(1):83-92, 1999.
Farese JP, Lust G, Williams AJ, Dykes NL, Todhunter RJ: Dorsolateral subluxation of femoral heads and distraction laxity for evaluation of canine hip joints. Am J Vet Res 60:1571-1576, 1999.
PubMed abstract
Burton-Wurster N, Farese JP, Todhunter RJ, Lust G: Site-specific variation in femoral head cartilage composition in dogs at high and low risk for development of osteoarthritis: Insights into lesion formation. Osteoarthritis Cart 7:486-497, 1999.
PubMed abstract
Lee DV, Bertram JEA, Todhunter RJ: Acceleration and balance in trotting dogs. J Exp Biol 202(Pt 24):3565-3573, 1999.
PubMed abstract
Todhunter RJ, Acland GM, Olivier M, Williams AJ, Vernier-Singer M, Burton-Wurster N, Farese JP, Gröhn YT, Gilbert RO, Dykes NL, Lust G: An outcrossed canine pedigree for linkage analysis of hip dysplasia. J Hered 90(1):83-92, 1999.
PubMed abstract
Farese JP, Todhunter RJ, Lust G et al.: Dorsolateral subluxation of hip joints measured in a weight-bearing position with radiography and computed tomography in dogs. Vet Surg 27:393-405, 1998.
PubMed abstract
MacLeod JN, Fubini SL, Gu DN, Tetreault JW, Todhunter RJ. Effect of synovitis and corticosteroids on transcription of cartilage matrix proteins. Am J Vet Res 59(8):1021-1026, 1998.
PubMed abstract
McNamara PS, Johnston SA, Todhunter RJ: Slow-acting, disease-modifying osteoarthritis agents. Vet Clin North Am Small Anim Pract 27(4):863-881, 1997.
PubMed abstract
Farquhar T, Bertram J, Todhunter RJ, Burton-Wurster N, Lust G: Variations in composition of cartilage from the shoulder joints of young adult dogs at risk for developing canine hip dysplasia. J Am Vet Med Assoc 210(10):1483-1485, 1997.
PubMed abstract
Todhunter RJ, Zachos TA, Gilbert RO, Erb HN, Williams, AJ, Burton-Wurster N, Lust G: Onset of epiphyseal mineralization and growth plate closure in radiographically normal and dysplastic Labrador retrievers. J Am Vet Med Assoc 210(10):1458-1462, 1997.
PubMed abstract
Todhunter RJ, Fubini SL, Wootton JAM, Lust G. Effect of methylprednisolone acetate on proteoglycan and collagen metabolism of articular cartilage explants. J. Rheumatol 23(7):1207-1213, 1996.
PubMed abstract
Farquhar T, Todhunter R, Fubini S, Burton-Wurster N, Lust G: Effect of methylprednisolone and mechanical loading on canine articular cartilage in explant culture. Osteoarthritis Cartilage 4(1):55-62, 1996.
PubMed abstract
Todhunter RJ, Yeh L-A, Sheldon A, Grisanzio L, Walker SL, Burton-Wurster N, Lust G: Effects of stromelysin activity on proteoglycan degradation of canine articular cartilage explants. Am J Vet Res 56(9):1241-1247, 1995.
PubMed abstract
Todhunter RJ, Lust G: Polysulfated glycosaminoglycan in the treatment of osteoarthritis. J Am Vet Med Assoc 204(8):1245-1251, 1994.
PubMed abstract
Suess RP Jr, Trotter EJ, Konieczynski D, Todhunter RJ, Bartel DL, Flanders JA: Exposure and postoperative stability of three medial surgical approaches to the canine elbow. Vet Surg 23(2):87-93, 1994.
PubMed abstract
Todhunter RJ, Lust G. Pathogenesis of canine hip dysplasia. In: Slatter D, ed. Textbook of Small Animal Surgery, Philadelphia: WB Saunders Co, 2003, pp 2009-2019.
Todhunter RJ, Johnston S. Osteoarthritis. In: Slatter D, ed. Textbook of Small Animal Surgery, Philadelphia: WB Saunders Co, 2003, pp 2208-2246.
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