|
Cellular & Molecular Physiology |
Bedford-Guaus, Sylvia |
events surrounding fertilization in mammalian species, particularly the horse; elucidate in vitro conditions to support stallion sperm capacitation |
Beyenbach, Klaus |
cellular transport mechanisms and electrolyte regulation; NaCl secretion in renal tubules |
Cohen, Paula |
mammalian meiosis; germ cell development; DNA repair mechanisms in recombination; genetic basis for nondisjunction in oocytes; transgenic and knockout mouse models for studying meiosis and recombination |
Currie, W. Bruce |
biology of pregnancy; cell biology of the early mammalian embryo |
Davisson, Robin |
Our studies examine the physiological and pathophysiological effects of targeted genetic alterations in animals (both germline and somatic) in order to investigate molecular mechanisms determining normal cardiovascular function and the pathogenesis of certain cardiovascular diseases. Within this framework, we focus on three major areas: 1) central neural control of blood pressure and autonomic function, with an emphasis on dissection of gene function in cardiovascular regulatory circuits of the brain in normal animals and in clinically relevant models of hypertension 2) molecular determinants of cardiac disease, particularly cardiac hypertrophy and heart failure; 3) molecular pathophysiology of preeclampsia using a novel genetic mouse model that spontaneously develops the cardinal features of this pregnancy-induced hypertensive disorder. Common themes linking all of our projects are the renin-angiotensin system and the role of oxidative stress. |
Fewtrell, Clare |
calcium and cell activation |
Kotlikoff, Michael |
molecular processes underlying excitation-contraction coupling, particularly in smooth muscle cells; role of specific sarcoplasmic reticular calcium release channels and sarcolemmal ion channels in cellular excitation and relaxation |
Lin, David |
axon guidance and target selection during development of mouse olfactory system using genetic, in vitro and genomic approaches; developmental biology;olfaction; azon guidance; mouse genetics; genomics; neurobiology |
Nikitin, Alexander |
experimental pathology of neoplasia in the mammary gland, the prostate, and the ovary; design and characterization of animal models for human cancer; conditional gulation of gene expression in temporal, spatial and cell type-specific manner; identification and characterization of early atypical cells during carcinogenesis; genetic evaluation of cell lineage-specific effects of tumor suppressor genes in mouse models; functional design of cell targeting by laser microdissection-peptide phage display technology |
Nowak, Linda |
membrane biophysics; molecular biology of glutamate receptors; cellular neurophysiology; pharmacology of synaptic transmission |
O'Brien, Timothy P. |
mouse developmental genetics; cell signaling and genomic regulatory networks; genome organization and patterning |
Parks, John |
spermatogenesis in vitro, gamete physiology, cryobiology |
Quaroni, Andrea |
cellular differentiation and growth of intestinal cells |
Quirk, Susan |
molecular and cellular aspects of ovarian function |
Roberson, Mark |
regulation of pituitary-specific gene expression by gonadotropin-releasing hormone |
Schimenti, John |
mouse genetics and functional genomics; genomic instability; genetic recombination; genetics of gametogenesis and development; use of ES cells to mutagenize the mouse genome |
Sharp, Geoffrey |
signal transduction and second messengers involved in the control of insulin release; intestinal ion and water transport |
Suarez, Susan |
sperm motility regulation and transport in the female reproductive tract |
Travis, Alexander |
biology of male germ cells; signaling and metabolism of sperm during capacitation; organization of lipid raft membrane sub-domains in sperm; conservation applications of germ cell reproductive technologies |
Weiss, Robert |
mechanisms for the maintenance of genomic integrity and their roles in normal development and Tumorigenesis |
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Membrane & Epithelial Physiology |
Fewtrell, Clare |
calcium and cell activation |
Nowak, Linda |
membrane biophysics; molecular biology of glutamate receptors; cellular neurophysiology; pharmacology of synaptic transmission |
Sharp, Geoffrey |
signal transduction and second messengers involved in the control of insulin release; intestinal ion and water transport |
Suarez, Susan |
sperm motility regulation and transport in the female reproductive tract |
Travis, Alexander |
biology of male germ cells; signaling and metabolism of sperm during capacitation; organization of lipid raft membrane sub-domains in sperm; conservation applications of germ cell reproductive technologies |
|
Behavioral Physiology |
Houpt, Katherine A. |
vertebrate social behavior, especially reproductive behavior; hormones and behavior; avian behavior; sex differences and their development; neuroethology of sexual behavior; comparative sexual behavior and reproductive biology |
Place, Ned |
mammalian reproductive biology, with a focus on the life history trade-offs associated with the timing of hormone secretion and reproductive effort. I have studied sexual differentiation and mating behavior of spotted hyenas under semi-natural conditions, the seasonal reproductive endocrinology of yellow-pine chipmunks in the field, and most recently, the effects of photoperiod on reproductive aging in Siberian hamsters. I strive to pursue basic research that is integrative and comparative, while also being biomedically and ecologically relevant. |
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Cardiovascular & Repiratory Physiology |
Ainsworth, Dorothy |
pathophysiology & pulmonary immunology |
Davisson, Robin |
Our studies examine the physiological and pathophysiological effects of targeted genetic alterations in animals (both germline and somatic) in order to investigate molecular mechanisms determining normal cardiovascular function and the pathogenesis of certain cardiovascular diseases. Within this framework, we focus on three major areas: 1) central neural control of blood pressure and autonomic function, with an emphasis on dissection of gene function in cardiovascular regulatory circuits of the brain in normal animals and in clinically relevant models of hypertension 2) molecular determinants of cardiac disease, particularly cardiac hypertrophy and heart failure; 3) molecular pathophysiology of preeclampsia using a novel genetic mouse model that spontaneously develops the cardinal features of this pregnancy-induced hypertensive disorder. Common themes linking all of our projects are the renin-angiotensin system and the role of oxidative stress. |
Gilmour, Robert |
cardiac electrophysiology, pharmacology |
Gleed, Robin |
respiration; hypoxia and pulmonary circulation; anesthesiology |
Kotlikoff, Michael |
molecular processes underlying excitation-contraction coupling, particularly in smooth muscle cells; role of specific sarcoplasmic reticular calcium release channels and sarcolemmal ion channels in cellular excitation and relaxation |
Ludders, John |
effects of inhalant and injectable anesthetics on avian physiology, more specifically on the control of ventilation in birds |
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Endocrinology |
Fortune, Joanne |
ovarian function |
Johnson, Patricia |
the process of follicle selection and development in the hen; development and characterization of the chicken as a model for human ovarian cancer |
Ludders, John |
effects of inhalant and injectable anesthetics on avian physiology, more specifically on the control of ventilation in birds |
Nikitin, Alexander |
experimental pathology of neoplasia in the mammary gland, the prostate, and the ovary; design and characterization of animal models for human cancer; conditional gulation of gene expression in temporal, spatial and cell type-specific manner; identification and characterization of early atypical cells during carcinogenesis; genetic evaluation of cell lineage-specific effects of tumor suppressor genes in mouse models; functional design of cell targeting by laser microdissection-peptide phage display technology |
O'Brien, Kimberly |
Calcium Metabolism and Bone Health; Control of Maternal/Fetal Nutrient; Partitioning and Cellular Mineral Transport; Micronutrient Status in International Settings; Development of Mass Spectrometric Methodology; Pediatric Bone Health; Pregnancy and Mineral Metabolism in Adolescents |
Place, Ned |
mammalian reproductive biology, with a focus on the life history trade-offs associated with the timing of hormone secretion and reproductive effort. I have studied sexual differentiation and mating behavior of spotted hyenas under semi-natural conditions, the seasonal reproductive endocrinology of yellow-pine chipmunks in the field, and most recently, the effects of photoperiod on reproductive aging in Siberian hamsters. I strive to pursue basic research that is integrative and comparative, while also being biomedically and ecologically relevant. |
Roberson, Mark |
regulation of pituitary-specific gene expression by gonadotropin-releasing hormone |
|
Environmental & Comparative Physiology |
Johnson, Patricia |
the process of follicle selection and development in the hen; development and characterization of the chicken as a model for human ovarian cancer |
Ludders, John |
effects of inhalant and injectable anesthetics on avian physiology, more specifically on the control of ventilation in birds |
Place, Ned |
mammalian reproductive biology, with a focus on the life history trade-offs associated with the timing of hormone secretion and reproductive effort. I have studied sexual differentiation and mating behavior of spotted hyenas under semi-natural conditions, the seasonal reproductive endocrinology of yellow-pine chipmunks in the field, and most recently, the effects of photoperiod on reproductive aging in Siberian hamsters. I strive to pursue basic research that is integrative and comparative, while also being biomedically and ecologically relevant. |
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Gastrointestinal & Metabolic Physiology |
Gunn, Teresa |
In vivo and in vitro approaches to mouse developmental and physiological genetics. We are focusing on the role of the Attractin-Mahogunin pathway in pigmentation and neurodegeneration; embryonic patterning; body weight regulation. We are also collaborating with Cornell veterinary cardiology group to dissect the genetic basis of ventricular arrhythmias and sudden death in dogs |
Loew, Ellis |
physiology of vision; sensory biophysics; sensory ecology and nutritional ophthalmology |
Lust, George |
biochemistry; metabolism and function of connective tissue; osteoarthritis |
O'Brien, Kimberly |
Calcium Metabolism and Bone Health; Control of Maternal/Fetal Nutrient; Partitioning and Cellular Mineral Transport; Micronutrient Status in International Settings; Development of Mass Spectrometric Methodology; Pediatric Bone Health; Pregnancy and Mineral Metabolism in Adolescents |
Quaroni, Andrea |
cellular differentiation and growth of intestinal cells |
Sharp, Geoffrey |
signal transduction and second messengers involved in the control of insulin release; intestinal ion and water transport |
|
Neural & Sensory Physiology |
Davisson, Robin |
Our studies examine the physiological and pathophysiological effects of targeted genetic alterations in animals (both germline and somatic) in order to investigate molecular mechanisms determining normal cardiovascular function and the pathogenesis of certain cardiovascular diseases. Within this framework, we focus on three major areas: 1) central neural control of blood pressure and autonomic function, with an emphasis on dissection of gene function in cardiovascular regulatory circuits of the brain in normal animals and in clinically relevant models of hypertension 2) molecular determinants of cardiac disease, particularly cardiac hypertrophy and heart failure; 3) molecular pathophysiology of preeclampsia using a novel genetic mouse model that spontaneously develops the cardinal features of this pregnancy-induced hypertensive disorder. Common themes linking all of our projects are the renin-angiotensin system and the role of oxidative stress. |
Howland, Howard |
human and animal vision; sensory physiology; mathematical biology |
Lin, David |
axon guidance and target selection during development of mouse olfactory system using genetic, in vitro and genomic approaches; developmental biology;olfaction; azon guidance; mouse genetics; genomics; neurobiology |
Loew, Ellis |
physiology of vision; sensory biophysics; sensory ecology and nutritional ophthalmology |
Nowak, Linda |
membrane biophysics; molecular biology of glutamate receptors; cellular neurophysiology; pharmacology of synaptic transmission |
Schaffer, Chris |
My group uses advanced optical techniques to observe and manipulate in vivo biological systems, with the goal of developing a microscopic-scale understanding of normal and disease-state physiological processes. |
|
Reproductive Physiology |
Bedford-Guaus, Sylvia |
events surrounding fertilization in mammalian species, particularly the horse; elucidate in vitro conditions to support stallion sperm capacitation |
Butler, W. Ron |
gonadoptropins and ovarian function; reproduction/nutrition interactions |
Cohen, Paula |
mammalian meiosis; germ cell development; DNA repair mechanisms in recombination; genetic basis for nondisjunction in oocytes; transgenic and knockout mouse models for studying meiosis and recombination |
Currie, W. Bruce |
biology of pregnancy; cell biology of the early mammalian embryo |
Fortune, Joanne |
ovarian function |
Johnson, Patricia |
the process of follicle selection and development in the hen; development and characterization of the chicken as a model for human ovarian cancer |
Meyers-Wallen, Vicki |
developmental biology; genetics |
Nikitin, Alexander |
experimental pathology of neoplasia in the mammary gland, the prostate, and the ovary; design and characterization of animal models for human cancer; conditional gulation of gene expression in temporal, spatial and cell type-specific manner; identification and characterization of early atypical cells during carcinogenesis; genetic evaluation of cell lineage-specific effects of tumor suppressor genes in mouse models; functional design of cell targeting by laser microdissection-peptide phage display technology |
O'Brien, Kimberly |
Calcium Metabolism and Bone Health; Control of Maternal/Fetal Nutrient; Partitioning and Cellular Mineral Transport; Micronutrient Status in International Settings; Development of Mass Spectrometric Methodology; Pediatric Bone Health; Pregnancy and Mineral Metabolism in Adolescents |
Parks, John |
spermatogenesis in vitro, gamete physiology, cryobiology |
Place, Ned |
mammalian reproductive biology, with a focus on the life history trade-offs associated with the timing of hormone secretion and reproductive effort. I have studied sexual differentiation and mating behavior of spotted hyenas under semi-natural conditions, the seasonal reproductive endocrinology of yellow-pine chipmunks in the field, and most recently, the effects of photoperiod on reproductive aging in Siberian hamsters. I strive to pursue basic research that is integrative and comparative, while also being biomedically and ecologically relevant. |
Roberson, Mark |
regulation of pituitary-specific gene expression by gonadotropin-releasing hormone |
Schimenti, John |
mouse genetics and functional genomics; genomic instability; genetic recombination; genetics of gametogenesis and development; use of ES cells to mutagenize the mouse genome |
Suarez, Susan |
sperm motility regulation and transport in the female reproductive tract |
Travis, Alexander |
biology of male germ cells; signaling and metabolism of sperm during capacitation; organization of lipid raft membrane sub-domains in sperm; conservation applications of germ cell reproductive technologies |
|
Physiological Genomics |
Davisson, Robin |
Our studies examine the physiological and pathophysiological effects of targeted genetic alterations in animals (both germline and somatic) in order to investigate molecular mechanisms determining normal cardiovascular function and the pathogenesis of certain cardiovascular diseases. Within this framework, we focus on three major areas: 1) central neural control of blood pressure and autonomic function, with an emphasis on dissection of gene function in cardiovascular regulatory circuits of the brain in normal animals and in clinically relevant models of hypertension 2) molecular determinants of cardiac disease, particularly cardiac hypertrophy and heart failure; 3) molecular pathophysiology of preeclampsia using a novel genetic mouse model that spontaneously develops the cardinal features of this pregnancy-induced hypertensive disorder. Common themes linking all of our projects are the renin-angiotensin system and the role of oxidative stress. |
Gunn, Teresa |
In vivo and in vitro approaches to mouse developmental and physiological genetics. We are focusing on the role of the Attractin-Mahogunin pathway in pigmentation and neurodegeneration; embryonic patterning; body weight regulation. We are also collaborating with Cornell veterinary cardiology group to dissect the genetic basis of ventricular arrhythmias and sudden death in dogs |
Kotlikoff, Michael |
molecular processes underlying excitation-contraction coupling, particularly in smooth muscle cells; role of specific sarcoplasmic reticular calcium release channels and sarcolemmal ion channels in cellular excitation and relaxation |
Lin, David |
axon guidance and target selection during development of mouse olfactory system using genetic, in vitro and genomic approaches; developmental biology;olfaction; azon guidance; mouse genetics; genomics; neurobiology |
Nikitin, Alexander |
experimental pathology of neoplasia in the mammary gland, the prostate, and the ovary; design and characterization of animal models for human cancer; conditional gulation of gene expression in temporal, spatial and cell type-specific manner; identification and characterization of early atypical cells during carcinogenesis; genetic evaluation of cell lineage-specific effects of tumor suppressor genes in mouse models; functional design of cell targeting by laser microdissection-peptide phage display technology |
O'Brien, Timothy P. |
mouse developmental genetics; cell signaling and genomic regulatory networks; genome organization and patterning |
Schimenti, John |
mouse genetics and functional genomics; genomic instability; genetic recombination; genetics of gametogenesis and development; use of ES cells to mutagenize the mouse genome |
Weiss, Robert |
mechanisms for the maintenance of genomic integrity and their roles in normal development and Tumorigenesis |
