Advancing the health and well-being of animals and people

Principal Investigator: Elia D. Tait-Wojno

Baker Institute for Animal Health
Sponsor: NIH - National Institute of Helth National Institute of Allergy and Infectious Diseases (NIAID)
Grant Number: 5K22AI116729-02
Title: Prostaglandin Regulation of Type 2 Inflammation
Project Amount: $106,380
Project Period: 07/01/17-06/30/18

DESCRIPTION (provided by applicant):  Examine mechanisms by which the PGD2-CRTH2 pathway influences ILC2 responses and helminth-induced type 2 inflammation in the lung, and will test how IL-33-dependent type 2 inflammation may be mediated through the PGD2-CRTH2 pathway, using cutting-edge approaches and complementary analyses of murine and human samples. Insights into how the PGD2-CRTH2 pathway regulates type 2 inflammation will inform the development and effective usage of therapies to treat type 2 inflammatory diseases.