College of Veterinary Medicine - Cornell University

Projects By PI

Projects by Dorothy Ainsworth

• Exercise-Induced Immunosuppression: A Cause of Illness and Vaccine Failures in Racehorses? (2000)
• Attenuating Exercise-Induced Immuno-suppression in Athletic Horses (2001)
• Influence of an Underlying Immune Environment on the Subsequent IgG Isotype Response to a Foreign Antigen (2002)
• Airway Epithelial Cell Contributions to the Immunopathogenesis of Heaves—Preliminary Investigations (2003)
• The Role of the Pulmonary Macrophages in Initiating the Inflammatory Response of Recurrent Airway Obstruction (2004)
• The Role of the Pulmonary Macrophages in Initiating the Inflammatory Response of Recurrent Airway Obstruction (Continuation Year 2 -2005)
• Flavonoids Inhibit Inflammatory Mediator Production by Pulmonary Mononuclear Cells Exposed to Haydust (2007)
• Modeling Equine Pulmonary Disorders in Vitro: Epithelial-Derived Proteins and Inflammatory Airway Diseases (2008)
• Deciphering the Mechanism of Equine Inflammatory Airway Disease in vitro (2009)

Projects by Douglas Antczak

• Horse Genome Project (1999)
• Horse Genome Project (2000)
• Horse Genome Project (2001)
• Horse Genome Project (2002)
• Horse Genome Project: Functional Genomics of the Equine Immune System (2003)
• Horse Genome Project: Functional Genomics of the Equine Immune System (2004)
• Horse Genome Project: Functional Genomics of the Equine Immune System (2005)
• Horse Genome Project: Functional Genomics Through Equine Microarrays (2006)
• Horse Genome Project: Functional Genomics through Equine Microarrays (Continuation Year 2 - 2006)
• Expressions of Microarrays and Equine Placental Development (2009)
• T-Cell Mediated Immunity and Vaccine Development in Horses (2013) with Rebecca Tallmadge & Nikolaus Osterrieder
  

Projects by Stephen Barr

• Endoproteases of Sarcocystis Neurona (1999)

Projects by Sylvia Bedford-Guaus

• Media and Molecular Pathways Conductive to Stallion Sperm Capacitation and Mobility Hyperactivation (2005)
• Media and Molecular Pathways Conductive to Stallion Sperm Capacitation and Mobility Hyperactivation (2006)
• Characterization of Equine Phospholipase C Zeta (PLC Zeta) as it Related to Stallion Fertility (2008) with Mark Roberson
• Further Characterization of the Specific Activity and Ultrastructural Localization of Phospholipase C Zeta in Fertile and Subfertile Stallions (2009) with Mark Roberson

Projects by Dwight Bowman

• Equine Protozoal Myeloencephalitis: Isolation of Potential Agents from Wildlife (1999)

Projects by Yung-Fu Chang

• Cloning of L. interrogans serovar pomona type Kennewicki Immunogen Genes (2000)
• Equine Leptospirosis: Part I. Vaccination Against Equine Leptospirosis in a Hamster Model (2001)
• Equine Lyme Disease: Antibiotic Treatment of B. burgdorferi Persistent Infection (2001)
• Virulence Factors of Serovar Pomona and Vaccine Development (2005)
• Virulence Factors of Serovar Pomona and Vaccine Development (2006)
• Vaccination Against Equine Leptospirosis (2008)

Projects by Jon Cheetham

• Diagnosis of Poor Performance in Racehorses (2011)

Projects by Thomas Divers

• Targeting Platelets as a New Treatment Strategy for Endotoxemia (2011)
• Etiology and Prevention of Equine Serum Hepatitis (Theiler's Disease) (2013) with Bud Tennant

Projects by Norm Ducharme

• New Field Diagnosis Modality for Upper Airway Obstructions in Horses (1999)
• Spectro-temporal Signature for Identification of Upper Airway Abnormalities in Exercising Horses (2000)
• Design of a Training and Therapeutic “DDSP” Collar to Prevent Dorsal Displacement of the Soft Palate (2002) with J. Brett Woodie
• Laryngeal Hemiplegia: Do We Have the Wrong Treatment? (2003) with J. Brett Woodie
• Management of Horses with Partial Paralysis of the Left Arytenoid Cartilage (2004)
• Steps Toward Novel Treatment of Laryngeal Hemiplegia: What is Really Happening to the Airflow and Local Forces? (2007)
• Factors Affecting Airway Stability of Horse Exercise: A Combined Neuroanatomical, Clinical and Engineering Methodology (2008) with Jeremy Rawlinson
• Factors Affecting Airway Stability of Horse Exercise: A Combined Neuroanatomical, Clinical and Engineering Methodology (2009, Year 2)with Jeremy Rawlinson
• An Exploratory Study into the Practical  Application of Regenerative Medicine Approach to Reconstruction of the Equine Upper Airway  (2013) with Brian Brown

Projects by Julia Felippe

• The Effect of CpG-oilgodeoxynucleotides in the Foal's Immune System (2004)
• The Effect of CpG-oilgodeoxynucleotides in the Foal's Immune System (2005)
• How Does the Immune System of the Foal Fight Against Rhodococcus equi Infection? (2006)
• How Does the Immune System of the foal Fight Against Rhodococcus equi Infection? (Continuation Year 2 - 2007)
• The Phagocyte Response Against R. Equi in Foals (2008) with Ute Schwab
• The Phagocyte Response Against R. Equi in Foals (2009)

Projects by Lisa Fortier

• The Establishment of Equine Embryonic Stem Cells (2003)
• Final Verification of Equine Embryonic Stem Cell (2004)
• Platelet Rich Plasma (PRP) Treatment for Tendonitis and suspensory Ligament Desmitis (2005)
• Characteristics of Stem Cells Derived from Bone Marrow Aspirate, Adipose Tissue and Muscle (2006)
• Characteristics of Stem Cells Derived from Bone Marrow Aspirates, Adipose Tissue and Muscles (2008)
• The Role of Telomerase and Small G-Proteins in Senescence of Articular Chondrocytes (2009)
• Identification of the Optimal Biologic to enhance Endogenous Stem Cell Recruitment and Homing for Facilitated Musculoskeletal Tissue Regeneration (2012)
• Cellular Biomarkers of Early Cartilage Injury Measured with Multiphoton Imaging (2013)

Projects by Susie Fubini

• Indices of Intra-Abdominal Fibrilolysis in Colic Foals: Pathogenic and Prognostic Markers (2008)
• Indices of Intra-Abdominal Fibrilolysis in Colic Foals: Pathogenic and Prognostic Markers (2009)

Projects by Robert Gilbert

• Controlled Postponement of Ovulation by Progestagen Treatment (2010)

Projects by Robert Gilmour

• Ionic Basis of Repolarization in Equine Heart: Relevance to Atrial Fibrillation and Acquired LQTS (2000)
• Are ERG K+ Channels in Equine GI Smooth Muscle Molecular Targets for Prokinetic Drugs? (2002) with J. Brett Woodie

Projects by Amy Glaser

• Detection of WNV Antibodies and Discrimination Between Vaccinated and Infected Horses (2002)

Projects by Kevin Haussler

• Back Motion in Horses During Different Gaits: Effects of Back Injuries (2000)
• Vertebral Movements and Applied Forces During Spinal Manipulative Therapy in Horses: A randomized Controlled Study (2001)

Projects by Katherine Houpt

• Effects of Iso-Caloric Diets Differing in Sweetness or Lactic Acid Production on Cribbing (2002)

Projects by Vicki Meyers-Wallen

• Generation of a Molecular Resource to Identify Gene Mutations Causing Inherited Equine Sterility and Infertility (2010)

Projects by Linda Mittel

• Detection of Spirochetes, Rickettsia, and other Bacteria and Parasitic Protozoa (often vector born) that Cause Fevers of Unknown Origin in Horses and in Horse-Associated Ticks in the Northeast, Mid-Atlantic, and Great Lake Regions (2011)
• Detection of Spirochetes, Rickettsia, and other Bacteria and Parasitic Protozoa (often vector borne) that Cause Fevers of Unknown Origin in Horses and in Horse-Associated Ticks in the Northeast, Mid-Atlantic, and Great Lakes Regions (2012)

Projects by Brad Njaa

• The Role of Cecal Histamine in the Pathogenesis of Acute, Alimentary Laminitis (2003) with J. Brett Woodie

Projects by Alan Nixon

• Growth Factor Gene Therapy Approaches to Equine Cartilage Repair (1999)
• Growth Factor Gene Therapy Approaches to Equine Cartilage Repair (2000)
• Growth Factor Gene Therapy Condrocyte Transplantation for Equine Cartilage Repair (2001)
• Growth Factor Gene Enhanced Chondrocyte Function Using Adeno-Associated Viral Vectors (2002)
• Growth Factor Gene Enhanced Cartilage Repair Using Adeno-associated Viral Vectors (2003)
• Gene Enhanced Cartilage Repair Using Multimodal IGF-1 and IL-1 Receptor Antagonist Therapy (2004)
• Enhanced Joint Function Through Targeted RNA Interference (2005)
• Enhanced Joint Function Through Targeted RNA Interference (2006)
• Joint Repair Through Targeted RNA Interference and Anabolic Gene Induction (2007)
• Pro-Inflammatory Cytokine Targets in Joint Disease and Check-Points for Gene Inhibition (2008)
• Genomic profiling of Osteochondritis Dissecans Using an Equine Whole Transcript Exon Array (2008)
• Genomic profiling of Osteochondritis Dissecans Using an Equine Whole Transcript Exon Array (2009)
• Recruiting The Stem Cell Niche for Equine Cartilage Repair (2012)
• Osteoarthritis Control through Combinatorial Stem Cell Therapy (2013)

Projects by Nikolaus Osterrieder

• The Importance of Equine Herpesvirus Type 1 Glycoproteins for Replication, Virulence and Vaccine Efficacy (2003)
• Equine Herpesvirus Type 1as a Vector to Immunize Against West Nile Virus and Equine Influenza (2004)
• Equine Herpesvirus Type 1 Virulence and Vaccine Efficacy (2004)
• Equine Herpesvirus Type 1 Virulence and Vaccine Efficacy (2005)
• Equine Herpesvirus Type 1 Virulence and Vaccine Efficacy (2006)
• Equine Herpesvirus Type 1 Virulence and Vaccine Efficacy (Continuation Year 2 - 2007)
• Therapy and Prevention of Equine Herpesvirus-1 (EHV-1)-Induced Disease (2008) with Gillian Perkins
• Therapy and Prevention of Equine Herpesvirus-1 (EHV-1)-Induced Disease (2009) with Gillian Perkins
• T-Cell Mediated Immunity and Vaccine Development in Horses (2013) with Douglas Antczak & Rebecca Tallmadge

Projects by Gillian Perkins

• Therapy and Prevention of Equine Herpesvirus-1 (EHV-1)-Induced Disease (2008) with Nikolaus Osterrieder
• Therapy and Prevention of Equine Herpesvirus-1 (EHV-1)-Induced Disease (2009) with Nikolaus Osterrieder
• Innate Immune Mechanisms and T-Cell Response to Equine Herpesvirus Type 1 in Latently Infected and Naive Horses (2013) with Bettina Wagner

Projects by Kenneth Rassnick

• An immunohistochemical Study of Cyclooxygenase-2 Expression on Squamous Cell Carcinoma of the Equine Cornea (2004)

Projects by Jeremy Rawlinson

• Factors Affecting Airway Stability of Horse Exercise: A Combined Neuroanatomical, Clinical and Engineering Methodology (2008) with Normand Ducharme
• Factors Affecting Airway Stability at Exercise: A Combined Neuroanatomical, Clinical and Engineering Methodology (2009, Year 2) with Normand Ducharme

Projects by Mark Roberson

• Characterization of Equine Phospholipase C Zeta (PLC Zeta) as it Related to Stallion Fertility (2008) with Sylvia Bedford-Guaus
• Further Characterization of the Specific Activity and Ultrastructural Localization of Phospholipase C Zeta in Fertile and Subfertile Stallions (2008) with Sylvia Bedford-Guaus

Projects by Ute Schwab

• The Phagocyte Response Against R. Equi in Foals (2008) with Julia Flaminio
• The Role of Platelets in the Pathogenesis of Equid Herpes Virus Type-1 Infection (2012)

Projects by Tracy Stokol

• Defining the Cause of Thrombosis in Equine Inflammatory Disease: Role of Tissue Factor - A New Diagnostic Approach? (2007)

Projects by Dietrich Volkmann

• Hormonal Function in Mares Suffering from Mare Reproductive Loss Syndrome (MRLS) (2002)

Projects by Bettina Wagner

• Role of IgE in Skin Hypersensitivities of the Horse (2005)
• IgE and IgG(T) Antibodies in Allergy of the Horse (2006)
• IgE and IgG(T) Antibodies in Allergy of the Horse (Continuation Year 2 - 2007)
• Analysis of the Innate Immune Response to EHV-1 Infection (Continuation Year 2 - 2007)
• Innate Immune Mechanisms and T-Cell Responses to Equine Herpesvirus Type 1 in Latently Infected and Naive Horses (2011)
• A Novel Strategy to Boost Antibody Production to EHV-1 in Neonates (2012)
  
• Innate Immune Mechanisms and T-Cell Response to Equine Herpesvirus Type 1 in Latently Infected and Naive Horses (2013) with Gillian Perkins

Projects by Gary Whittaker

• Emergence and Establishment of Influenza Virus in Equines (2007)
• Emergence and Establishment of Influenza Virus in Equines (2008)

Projects by Brett Woodie

• Are ERG K+ Channels in Equine GI Smooth Muscle Molecular Targets for Prokinetic Drugs? (2002) with Robert F. Gilmour
• Design of a Training and Therapeutic “DDSP” Collar to Prevent Dorsal Displacement of the Soft Palate (2002) with Normand G. Ducharme
• Laryngeal Hemiplegia: Do We Have the Wrong Treatment? (2003) with Normand Ducharme
• The Role of Cecal Histamine in the Pathogenesis of Acute, Alimentary Laminitis (2003) with Brad Njaa