T3-006 Veterinary Research Tower
Phone: 607 253 3082
Fax: 607 253 3578
Libert Lab Website: Libert.Cornell.edu
Sergiy Libert obtained Master’s degree in physics from Clarkson University, NY. After becoming interested in genetic control of lifespan and longevity he switched fields of research and obtained Ph.D. from Baylor College of Medicine, TX. After postdoctoral fellowship at Massachusetts Institute of Technology, Sergiy Libert was recruited to Cornell University, Department of Biomedical Sciences.
Most living organisms, including humans, age. Over time the ability to do physical and intellectual work deteriorates, and susceptibility to infectious, metabolic, and neurodegenerative diseases increases, which leads to general fitness decline and ultimately to death. Work in model organisms has demonstrated that genetic and environmental manipulations can prevent numerous age-associated diseases, improve health at advanced age, and increase life span.
My laboratory uses a diverse range of techniques to study the process of aging. We use mouse models, cell culture, biochemistry, and computational methods to better understand normal and pathological process that accompany human aging, and to develop interventions to delay aging and ameliorate age-related diseases such as cancer, metabolic syndrome, and neuro-degeneration.
- Sergiy Libert, Kelli Pointer, Michael Bonkowski, Scott D. Pletcher, Leonard Guarente, Deviation of innate circadian period from 24 hours reduces longevity in mice, Aging Cell, 2012, Oct;11(5):794-800
- Sergiy Libert, Kelli Pointer, Eric L. Bell, Abhirup Das, Dena Cohen, John M. Asara, Karen Kapur, Sven Bergmann, Martin Preisig, Takeshi Otowa, Kenneth S. Kendler, Xiangning Chen, John M. Hettema, Edwin J. van den Oord, Justin P. Rubio, Leonard Guarente, SIRT1 activates MAO-A in the brain to mediate anxiety and exploratory drive, Cell, 2011, Dec 23; 147:1–14.
- Sergiy Libert, Jessica Zwiener, Xiaoween Chu, Wayne VanVoorhies, Gregg Roman, Scott D. Pletcher, Regulation of Drosophila lifespan by olfaction and food-derived odors, Science, 2007, Feb (315), 1133-7.
- Sergiy Libert, Yufang Chao, Jessica Zwiener, Scott D. Pletcher, Realized immune response is enhanced in long-lived puc and chico mutants but is unaffected by dietary restriction, Molecular Immunology, 2008, Feb; 45(3):810-7.
Immunofluorescent image of the hippocampus of the young (left) and old (right) animal is shown. DNA stain is green; DCX stain (marker for newly-born neurons) is red. Notice the decline in neurogenesis with advanced age.
Oocyte during meiosis is shown. DNA stain is green; Tubulin stain is red. It is believed that epigenetic changes that are set early in life contribute to health and longevity of the organism. Environmental parameters, such as diet and stress had been shown to influence epigenetic information.
Sirtuins are NAD+-dependent enzymes that can relay the nutritional information to activate or suppress the appropriate metabolic pathways. SIRT1, NAD+-dependent deacetylase is shown. It is believed that by changing activity of such enzymes we can influence longevity and health of the organisms.