Karel Schat, College of Veterinary Medicine

Avian tumor virology and immunology, molecular biology of Marek's disease virus and chicken infectious anemia virus, avian virology, avian immunology, avian intestinal virus infections and intestinal immunity.

Michael L. Schuler, Chemical Engineering

Bioengineering in the areas of: Structured models; heterologous protein expression systems (esp. E. coli and insect cell culture-baculovirus system); cell culture analogs for pharmacokinetic models; multidrug resistance mechanisms; in vitro toxicology; plant cell tissue culture; biodegradation and bioremediation.

David Shalloway, Dept of Molecular Biology and Genetics

The Src family of tyrosine kinases is required for cells to progress from the G2 phase of the cell cycle into mitosis. Previous work from the Shalloway laboratory showed that Src is activated during mitosis and identified a primary mitotic target, the RNA binding protein Sam68. The protein kinase activity of the Raf-1 proto-oncoprotein was also found to be stimulated at mitosis and so the possibility that Raf-1 is a primary target of Src at G2/M is being explored. The role of Ras and other signaling proteins in Raf-1 activation at G2/M and whether Raf-1 activation leads to activation of MAPK pathways at G2/M is also being examined, as are the questions of whether Raf-1 and downstream effector pathways are required for cells to enter mitosis and if Raf-1 plays a role in cellular decisions at G2/M to divide or undergo apoptosis. A second area of study involves elucidating the cellular function of Sam68 by identifying the biologically relevant RNA targets with which Sam68 interacts. The Shalloway laboratory is investigating the mechanisms by which Src and cell cycle regulators might regulate Sam68 function and plans to exploit the documented interaction between Sam68 and components of the poliovirus RNA replication machinery to gain insight into normal Sam68 function.

Kenneth Simpson, College of Veterinary Medicine
Research interests include gastroenterology and models of infectious origin of GI lymphoma in a feline model of H. Pylori.

Patrick Stover, Dept of Nutritional Sciences
Regulation of folate catabolism; relationships between folate metabolism and gene expression during development; development of transgenic animals for metabolic research; structure and function and mechanistic studies of serine hydroxymethyl-transferase; and influence of iron status on folate and homocysteine metabolism

Bud Tennant, College of Veterinary Medicine
Gastrointestinal and liver diseases of domestic animals. Viral hepatitis, mechanisms of hepatic injury, and hepatocarcinogenesis