SWAINSONINE POISONING, MANNOSIDOSIS
 
Description    The toxic alkaloid swainsonine, found in several plants, is a potent inhibitor of mannosidase and causes neurologic and behavioral abnormalities. Vacuolation of tissues due to accumulation of mannoside is seen at necropsy.
 
Species   Bovine, Equine, Caprine, Ovine
 
Signs   Abnormal behavior, aggression, changing habits, Abnormal proprioceptive positioning, Abortion or weak newborns, Agalactia, Anorexia, Ataxia, Blindness, Change in voice, Difficulty in prehending or chewing food, Dullness, Dysmetria, Excitement, Generalized lameness or stiffness, Generalized weakness, Head pressing, Hyperesthesia, Inability to stand, Lacrimation, Nystagmus, Paraparesis, Propulsion, Reluctant to move, Rough hair coat, Skin edema, Trembling, Tremor, Underweight, poor condition, thin, emaciated, unthriftiness, ill thrift, Weight loss
 
References   Takeda S. Cerebellar Ataxia Suspected to Be Caused by Oxytropis glabra Poisoning in Western Mongolian Goats. J Vet Med Sci 2014;76:839 [Web Reference]
Mendonca FS. Alpha-mannosidosis in goats caused by the swainsonine-containing plant Ipomoea verbascoidea. J Vet Diagn Invest 2012;24:90 [Web Reference]
Finnie J. Neurological diseases of ruminant livestock in Australia. II: toxic disorders and nutritional deficiencies. Aust Vet J 2011;89:247 [Web Reference]
Panter KE. Effects of Xenobiotics and Phytotoxins on Reproduction in Food Animals. Vet Clin N A Food Anim Pract 2011;27:429 [Web Reference]
Nollet H. Suspected swainsonine poisoning in a Belgian horse. Eq Vet Educ 2008;20:62 [Web Reference]
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