Description    Toxic hepatic failure affected 2-5 day old foals. The disease was reproduced by oral inoculation of foals with a commercial paste that contained iron. An indistinguishable syndrome was produced by administration of 16 mg/kg ferrous fumarate to foals. Intramuscular injections of horses with an iron-carbohydrate preparations was followed by death within 15 minutes and toxicity can follow massive doses of oral iron.
Species   Equine
Signs   Abnormal pupillary response to light, Agalactia, Anorexia, Ataxia, Blindness, Circling, Cold skin, Colic, Coma, Diarrhea, Dullness, Dysmetria, Dyspnea, Epistaxis, Excitement, Fever, Forelimb spasms, Generalized weakness, Head pressing, Hematuria, Hemorrhage of any body part or clotting failure, Hindlimb spasms, Hypothermia, Icterus, Inability to stand, Increased respiratory rate, Melena or occult blood in feces, stools, Nystagmus, Prolonged capillary refill time, Propulsion, Red or brown urine, Seizures or syncope, Sudden death, Sweating, Tachycardia, Trembling, Tremor
References   Casteel SW. Metal toxicosis in horses. Vet Clin N A: Eq Pract 2001;17:517
Mullaney TP. Iron toxicity in neonatal foals. EVJ 1988;20:119
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