Description    Nonsteroidal anti-inflammatory, antipyretic drugs can be toxic. Gastrointestinal, renal, and/or hepatotoxicity are most common.
Species   Canine, Feline
Signs   Abnormal behavior, aggression, changing habits, Anorexia, Ascites, Ataxia, Bloody stools, feces, hematochezia, Brown color, mucous membranes, Chemosis, Cold skin, Colic, Coma, Cyanosis, Dark color stools, feces, Decreased amount of stools, absent feces, constipation, Decreased, absent thirst, hypodipsia, adipsia, Dehydration, Diarrhea, Dullness, Dysmetria, Dyspnea, Excessive salivation, Excitement, Generalized weakness, Head, face, ears, jaw, nose, nasal, swelling, Hematemesis, Hematuria, Hemoglobinuria or myoglobinuria, Hyperesthesia, Hypothermia, Icterus, Inability to stand, Increased respiratory rate, Melena or occult blood in feces, stools, Neck swelling, Oliguria or anuria, Oral mucosal ulcers, vesicles, Pain on external abdominal pressure, Pale, Paraparesis, Polydipsia, Polyuria, Prolonged capillary refill time, Proteinuria, Red or brown urine, Seizures or syncope, Skin edema, Tachycardia, Tetraparesis, Trembling, Tremor, Underweight, poor condition, thin, emaciated, unthriftiness, ill thrift, Vomiting or regurgitation, Weight loss
References   Kjaergaard AB. Treatment of carprofen overdose with therapeutic plasma exchange in a dog. J Vet Emerg Crit Care 2018;Jun [Web Reference]
Eskafian H. Gastroscopic Study of Meloxicam, Tramadol, and Their Combined Administration on the Development of Gastric Injuries in Dogs. Topics Comp Anim Med 2017;32:109 [Web Reference]
Yi EM. Topical flurbiprofen toxicosis in a cat. J Vet Emerg Crit Care 2017;27:707 [Web Reference]
Walton S. Treatment of ibuprofen intoxication in a dog via therapeutic plasma exchange. J Vet Emerg Crit Care 2017;27:451 [Web Reference]
Walton S. Treatment of meloxicam overdose in a dog via therapeutic plasma exchange. J Vet Emerg Crit Care 2017;27:444 [Web Reference]
Robben JH. Lipid Therapy for Intoxications. Vet Clin North Am Small Anim Pract 2017;47:435 [Web Reference]
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