Description    Primary Hypoadrenocorticism results from adrenal cortical failure leading to deficiency of mineralocorticoids and/or glucocorticoids. An autoimmune pathogenesis is suspected and there is a genetic basis in dogs although the mode of inheritance is undetermined. Typically affects young to middle aged dogs, females more than males. Other causes include: destruction of the adrenal cortex by neoplasia; infarcts; inflitrative disease such as tuberculosis, histoplasmosis, blastomycosis, amyloidosis; or administration of treatments for hyperadrenocorticism. Secondary Hypoadrenocorticism due to insufficient ACTH stimulation results from hypothalamic or pituitary lesions or prolonged exogenous glucocorticoid administration. Clinical signs can wax and wane. Acute severe disease (adrenal crisis) might be due to adrenal infarction or termination of the chronic phase. Concurrent renal failure is common. Megaesophagus might occur.
Species   Canine
Signs   Alopecia, Anorexia, Ascites, Ataxia, Bloody stools, feces, hematochezia, Bradycardia, Cold skin, Colic, Coma, Decreased amount of stools, absent feces, constipation, Dehydration, Diarrhea, Disoriented, Dullness, Dysmetria, Dyspnea, Exercise intolerance, Fever, Forelimb spasms, Generalized weakness, Hematemesis, Hindlimb lameness, Hindlimb spasms, Hypothermia, Inability to stand, Increased respiratory rate, Melena or occult blood in feces, stools, Pain on external abdominal pressure, Pale, Paraparesis, Polydipsia, Polyuria, Prolonged capillary refill time, Reluctant to move, Rough hair coat, Seizures or syncope, Skin edema, Sudden death, Tachycardia, Tetraparesis, Trembling, Tremor, Underweight, poor condition, thin, emaciated, unthriftiness, ill thrift, Urinary incontinence, Vomiting or regurgitation, Weak pulse, Weight loss
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