5-FLUOROURACIL TOXICITY IN DOGS
 
Description    Solutions and creams containing 5-Fluorouracil used for treatment of people have poisoned dogs. Clinical signs usually develop within an hour; bone marrow suppression can develop in dogs that survive the initial exposure.
 
Species   Canine
 
Signs   Abnormal behavior, aggression, changing habits, Alopecia, Anorexia, Arrhythmia, Ataxia, Blindness, Bloody stools, feces, hematochezia, Bradycardia, Coma, Cyanosis, Decreased respiratory rate, Dehydration, Diarrhea, Dullness, Dysmetria, Dyspnea, Epistaxis, Excessive salivation, Gagging, retching, Generalized weakness, Hematemesis, Hemorrhage of any body part or clotting failure, Inability to stand, Increased respiratory rate, Lacrimation, Mucous, mucoid stools, feces, Nystagmus, Pale, Petechiae, ecchymoses, purpura, Seizures or syncope, Sudden death, Tachycardia, Trembling, Tremor, Vomiting or regurgitation
 
References   Friedenberg SG. Successful treatment of a dog with massive 5-fluorouracil toxicosis. J Vet Emerg Crit Care 2013;23:643 [Web Reference]
Sayre RS. Accidental and experimentally induced 5-fluorouracil toxicity in dogs. J Vet Emerg Crit Care 2012;22:545 [Web Reference]
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