PHOSPHATE-CONTAINING ENEMA OR URINARY ACIDIFIER TOXICITY
 
Description    Use of phosphate-containing enemas in cats is contraindicated; hypocalcemia, hyperphosphatemia and hypernatremia can occur after their use. Cats which have been obstipated for some time are at higher risk as they might be dehydrated and have preexisting electrolyte imbalances. The risk appears to be lower in dogs. There is also a report of toxicity in cats associated with administration of phosphate-containing urinary acidifier.
 
Species   Canine, Feline
 
Signs   Anorexia, Ataxia, Bloody stools, feces, hematochezia, Cold skin, Coma, Cyanosis, Dehydration, Diarrhea, Dryness oral mucosa, Dullness, Excessive salivation, Generalized weakness, Hypothermia, Inability to stand, Increased respiratory rate, Pale, Prolonged capillary refill time, Seizures or syncope, Tachycardia, Tetany, Trembling, Vomiting or regurgitation, Weak pulse
 
References   McAlees TJ. Sodium phosphate enema intoxication in a dog. Aust Vet Practit 2010;40:2
Gough A. Calcium disorders part 3: hypocalcemia. UK Vet 2004;9:No.7:47
Dhupa N. Hypocalcemia and hypomagnesemia. Vet Clin N A: Small Anim Pract 1998;28:587
Fulton RB. Poisoning induced by administration of a phosphate-containing urinary acidifier in a cat. JAVMA 1991;198:883
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