Description    Dogs or cats are sometimes exposed to avermectin products produced for other species; there are reports of reactions to such treatments. Collies are most susceptible but toxicity is not limited to that breed.
Species   Canine, Feline
Signs   Abnormal anal, perineal, tail reflexes, Abnormal behavior, aggression, changing habits, Abnormal forelimb reflexes, Abnormal hindlimb reflexes, Abnormal panniculus reflex, Abnormal proprioceptive positioning, Abnormal pupillary response to light, Anorexia, Arrhythmia, Ataxia, Back hypoesthesia, Blindness, Bradycardia, Coma, Cyanosis, Deafness, Decreased respiratory rate, Dehydration, Disoriented, Dullness, Dysmetria, Dyspnea, Excessive or decreased sleeping, Excessive salivation, Fever, Forelimb hypoesthesia, Forelimb spasms, Generalized weakness, Head, face, neck spasms, Head, face, neck, tongue hypoesthesia, Hindlimb hypoesthesia, Hindlimb spasms, Hyperesthesia, Hypothermia, Inability to stand, Increased respiratory rate, Miosis, Mydriasis, Nystagmus, Propulsion, Seizures or syncope, Sinus arrhythmia, Strabismus, Sudden death, Tachycardia, Tail, anal hypoesthesia, Trembling, Tremor, Vomiting or regurgitation, Weak pulse
References   Parker HG. Genomic Analyses Reveal the Influence of Geographic Origin, Migration, and Hybridization on Modern Dog Breed Development. Cell Reports 2017;19:697 [Web Reference]
Robben JH. Lipid Therapy for Intoxications. Vet Clin North Am Small Anim Pract 2017;47:435 [Web Reference]
Mizukami K. Molecular prevalence of multiple genetic disorders in Border collies in Japan and recommendations for genetic counselling. Vet J 2016;214:21 [Web Reference]
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