AVERMECTINS, MILBEMYCINS, MACROCYLIC LACTONE, IVERMECTIN, TOXICITY
 
Description    Dogs or cats are sometimes exposed to avermectin products produced for other species; there are reports of reactions to such treatments.
 
Species   Canine, Feline
 
Signs   Abnormal anal, perineal, tail reflexes, Abnormal behavior, aggression, changing habits, Abnormal forelimb reflexes, Abnormal hindlimb reflexes, Abnormal panniculus reflex, Abnormal proprioceptive positioning, Abnormal pupillary response to light, Anorexia, Arrhythmia, Ataxia, Back hypoesthesia, Blindness, Bradycardia, Coma, Cyanosis, Deafness, Decreased respiratory rate, Dehydration, Disoriented, Dullness, Dysmetria, Dyspnea, Excessive or decreased sleeping, Excessive salivation, Fever, Forelimb hypoesthesia, Forelimb spasms, Generalized weakness, Head, face, neck spasms, Head, face, neck, tongue hypoesthesia, Hindlimb hypoesthesia, Hindlimb spasms, Hyperesthesia, Hypothermia, Inability to stand, Increased respiratory rate, Miosis, Mydriasis, Nystagmus, Propulsion, Seizures or syncope, Sinus arrhythmia, Strabismus, Sudden death, Tachycardia, Tail, anal hypoesthesia, Trembling, Tremor, Vomiting or regurgitation, Weak pulse
 
References   Pollio D. Electroretinographic changes after intravenous lipid emulsion therapy in a dog and a foal with ivermectin toxicosis. Vet Ophthalmol 2018;21:82 [Web Reference]
Dekel Y. Frequency of canine nt230(del4) MDR1 mutation in prone pure breeds, their crosses and mongrels in Israel - insights from a worldwide comparative perspective. BMC Vet Res 2017;13:333 [Web Reference]
Parker HG. Genomic Analyses Reveal the Influence of Geographic Origin, Migration, and Hybridization on Modern Dog Breed Development. Cell Reports 2017;19:697 [Web Reference]
Robben JH. Lipid Therapy for Intoxications. Vet Clin North Am Small Anim Pract 2017;47:435 [Web Reference]
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