MOXIDECTIN TOXICITY IN DOGS
 
Description    Moxidectin is a milbemycin endectocide. Dog ingesting large amounts of this agent, which is used to deworm horses and as a prophylactic heartworm medication in dogs, can develop neurologic and respiratory signs.
 
Species   Canine
 
Signs   Abnormal anal, perineal, tail reflexes, Abnormal behavior, aggression, changing habits, Abnormal forelimb reflexes, Abnormal hindlimb reflexes, Abnormal lung or pleural sounds, Abnormal panniculus reflex, Abnormal pupillary response to light, Anorexia, Arrhythmia, Ataxia, Blindness, Bradycardia, Circling, Coma, Congestion oral mucous membranes, Cyanosis, Decreased respiratory rate, Disoriented, Dullness, Dysmetria, Dyspnea, Excessive salivation, Fever, Generalized weakness, Hyperesthesia, Hypothermia, Inability to stand, Increased respiratory rate, Miosis, Mydriasis, Reluctant to move, Seizures or syncope, Sinus arrhythmia, Sudden death, Tachycardia, Trembling, Tremor, Vomiting or regurgitation
 
References   Robben JH. Lipid Therapy for Intoxications. Vet Clin North Am Small Anim Pract 2017;47:435 [Web Reference]
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