CARBADOX TOXICITY IN PIGS
 
Description    Carbadox (methyl-3- (2-quinoxalinylmethylene) carbazate-N1, N4-dioxide) has been fed to pigs. Experimental carbadox toxicity has occurred at dose rates of 150 mg/kg of feed, and accidental overfeeding has led to toxicity in the field. There is destruction of the adrenal zona glomerulosa; the inability to produce aldosterone causes hyponatremia and hyperkalemia and a decreased sodium/potassium ratio.
 
Species   Porcine
 
Signs   Abnormal proprioceptive positioning, Abortion or weak newborns, Agalactia, Anorexia, Ataxia, Constant or increased vocalization, Cyanosis, Decreased amount of stools, absent feces, constipation, Dysmetria, Generalized weakness, Lack of growth or weight gain, Pale, Paraparesis, Rough hair coat, Tachycardia, Underweight, poor condition, thin, emaciated, unthriftiness, ill thrift, Weight loss
 
References   Power SB. Accidental carbadox overdosage in pigs in an irish weaner-producing herd. Vet Rec 1989;124:367
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