Description    In Toxic Hepatopathy there is hepatocytic necrosis with little inflammation on liver biopsy. Can be due to a known toxin but in some cases no such agent can be identified. Several bacteria have been associated with Hepatitis. Severity ranges from acutely-fatal to chronic subclinical disease.
Species   Canine, Feline
Signs   Abdominal distention, Abnormal proprioceptive positioning, Anorexia, Ataxia, Blindness, Bloody stools, feces, hematochezia, Bradycardia, Cold skin, Coma, Decreased amount of stools, absent feces, constipation, Dehydration, Diarrhea, Dullness, Dysmetria, Excessive salivation, Fever, Generalized weakness, Hematemesis, Hematuria, Hemorrhage of any body part or clotting failure, Hepatosplenomegaly, Hypothermia, Icterus, Increased respiratory rate, Melena or occult blood in feces, stools, Mucous, mucoid stools, feces, Pain on external abdominal pressure, Pale, Polydipsia, Polyuria, Prolonged capillary refill time, Red or brown urine, Reluctant to move, Sudden death, Tachycardia, Underweight, poor condition, thin, emaciated, unthriftiness, ill thrift, Vomiting or regurgitation, Weight loss
References   Im J. Canine Hepatitis Associated with Intrahepatic Bacteria in Three Dogs. JAAHA 2018;54:65 [Web Reference]
Pashmakova MB. Agreement between microscopic examination and bacterial culture of bile samples for detection of bactibilia in dogs and cats with hepatobiliary disease. JAVMA 2017;250:1007 [Web Reference]
Bosseler L. Suspected phenobarbitone hypersensitivity with acute liver failure in a dog. N Z Vet J 2017;65:168 [Web Reference]
Thawley V. Acute Liver Injury and Failure. Vet Clin North Am Small Anim Pract 2017;47:617 [Web Reference]
Gow AG. Hepatic Encephalopathy. Vet Clin North Am Small Anim Pract 2017;47:585 [Web Reference]
Marolf AJ. Diagnostic Imaging of the Hepatobiliary System : An Update. Vet Clin North Am Small Anim Pract 2017;47:555 [Web Reference]
Copyright © 2018 Cornell University College of Veterinary Medicine