Description    People use a variety of mind-altering and muscle-relaxing agents; dogs and cats can be poisoned by ingestion of these drugs. The antidepressant Mirtazapine has been used as a feline appetite stimulant; signs of toxicity began from 15 minutes to 3 hours following accidental or therapeutic administration of excessive amounts and resolved after 1248 hours.
Species   Canine, Feline
Signs   Abnormal behavior, aggression, changing habits, Abnormal forelimb reflexes, Abnormal hindlimb reflexes, Abnormal pupillary response to light, Alopecia, Anorexia, Arrhythmia, Ataxia, Back spasms, Blindness, Bradycardia, Circling, Cold skin, Coma, Constant or increased vocalization, Cyanosis, Decreased respiratory rate, Diarrhea, Disoriented, Dullness, Dysmetria, Dyspnea, Excessive salivation, Excitement, Fever, First degree atrioventricular heart block, Forelimb spasms, Generalized weakness, Head tilt, Head, face, neck spasms, Hindlimb spasms, Hyperesthesia, Hypertonia of muscles, myotonia, Hypothermia, Inability to stand, Increased respiratory rate, Miosis, Mydriasis, Nystagmus, Opisthotonus, Polydipsia, Polyphagia, Propulsion, Pruritus, Reluctant to move, Second degree atrioventricular heart block, Seizures or syncope, Sinus tachycardia, Skin erythema, Sudden death, Tachycardia, Trembling, Tremor, Urinary incontinence, Ventricular tachycardia, Vomiting or regurgitation, Weak pulse
References   Ahn J-O. Accidental afloqualone intoxication in two dogs. J Vet Med Sci 2018;80:152 [Web Reference]
Robben JH. Lipid Therapy for Intoxications. Vet Clin North Am Small Anim Pract 2017;47:435 [Web Reference]
Ferguson LE. Mirtazapine toxicity in cats: retrospective study of 84 cases (20062011). J Feline Med Surg 2016;18:868 [Web Reference]
Copyright © 2018 Cornell University College of Veterinary Medicine