Description    Neoplasms of the urinary bladder in cattle, including hemangiomas, hemangiosarcomas, transitional cell carcinomas, papillomas, fibromas and adenomas are caused by long-term ingestion of bracken fern (PTERIDIUM AQUILINUM) and possibly other ferns such as rock fern (CHEILANTHES SIEBERI). Usually 4-6 years old when signs first noted. A similar condition has been produced experimentally in sheep. Neoplasms such as lymphoma not associated with fern ingestion also occur in ruminants. Benign polyps of the urinary bladder induce clinical, laboratory and radiographic characteristics similar to neoplasia of the bladder.
Species   Bovine, Caprine, Ovine
Signs   Abnormal behavior, aggression, changing habits, Agalactia, Anorexia, Ascites, Colic, Dehydration, Dullness, Dysuria, Enlarged ureter, Enlarged, distended, urinary bladder, Generalized weakness, Hematuria, Hemoglobinuria or myoglobinuria, Hemorrhage of any body part or clotting failure, Icterus, Inability to stand, Increased frequency of urination, Internal abdominal mass, Lack of growth or weight gain, Oliguria or anuria, Pale, Palpable calculi, swelling or mass, bladder, Palpable enlarged kidney , Petechiae, ecchymoses, purpura, Proteinuria, Red or brown urine, Skin edema, Tachycardia, Underweight, poor condition, thin, emaciated, unthriftiness, ill thrift, Urinary incontinence, Weight loss
References   Russo V. Sigma 2 receptor expression levels in blood and bladder from healthy and bladder cancer cattle. Vet Comp Oncol 2017;15:1503 [Web Reference]
Roperto S. Bovine Papillomavirus Type 13 Expression in the Urothelial Bladder Tumours of Cattle. Transbound Emerg Dis 2016;63:628 [Web Reference]
Roperto S. Detection of bovine papillomavirus type 14 DNA sequences in urinary bladder tumors in cattle. Vet Microbiol 2016;190:1 [Web Reference]
Russo V. ERas protein is overexpressed and binds to the activated platelet-derived growth factor β receptor in bovine urothelial tumour cells associated with papillomavirus infection. The Vet J 2016;212:44 [Web Reference]
Bocaneti F. Bovine Papillomavirus: New Insights into an Old Disease. Transboundary Emerg Dis 2016;63:1423 [Web Reference]
Raoofi A. Transitional cell papilloma and leiomyoma of the urinary bladder in two goats Vet Rec 2007;160:56 [Web Reference]
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