SIDA CARPINIFOLIA POISONING IN RUMINANTS
 
Description    Ruminants in Brazil grazing the perennial shrub SIDA CARPINIFOLIA developed neurologic disease which was reproduced by experimental feedings. At necropsy there was vacuolation in several tissues and a pattern of staining consistent with alpha-mannosidosis; swainsonine was the toxic constituent of the plant.
 
Species   Bovine, Caprine, Ovine
 
Signs   Ataxia, Diarrhea, Dysmetria, Hyperesthesia, Inability to stand, Lack of growth or weight gain, Trembling, Tremor, Underweight, poor condition, thin, emaciated, unthriftiness, ill thrift, Weight loss
 
References   Furlan FH. Spontaneous Lysosomal Storage Disease Caused by Sida carpinifolia (Malvaceae) Poisoning in Cattle. Vet Pathol 2009;46:343 [Web Reference]
Seitz AL. Use of lectin histochemistry to diagnose SIDA CARPINIFOLIA (Malvaceae) poisoning in sheep. Vet Rec 2005;156:386
Colodel EM. Identification of swainsonine as a glycoside inhibitor responible for SIDA CARPINIFOLIA poisoning. Vet Human Toxicol 2002;44:177
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