Description    The polyphenol gossypol in cottonseed can be toxic to ruminants especially the young. Systemic clinical signs appear to be due to myopathy including cardiac myopathy. In bulls gossypol can cause decrease sperm production, increased abnormal sperm, and delayed reproductive development.
Species   Bovine, Caprine, Ovine
Signs   Abdominal distention, Agalactia, Anorexia, Ascites, Coughing, Diarrhea, Dryness of skin or hair, Dullness, Dyspnea, Excessive salivation, Female infertility, Fever, Generalized weakness, Head, face, ears, jaw, nose, nasal, swelling, Hematuria, Hemoglobinuria or myoglobinuria, Icterus, Inability to stand, Increased respiratory rate, Lack of growth or weight gain, Lacrimation, Male infertility, Mucoid nasal discharge, Pale, Peripheral venous distention, Red or brown urine, Rough hair coat, Rumen hypomotility or atony, Seizures or syncope, Skin crusts, Skin edema, Sudden death, Tachycardia, Underweight, poor condition, thin, emaciated, unthriftiness, ill thrift, Weight loss
References   Duarte Júnior MF. Free gossypol supplementation frequency and reproductive toxicity in young bulls. Theriogenology 2018;Jan [Web Reference]
El-Mokadem MY. Alleviation of reproductive toxicity of gossypol using selenium supplementation in rams. J Anim Sci 2012;90:3274 [Web Reference]
Nicholson SS. Southeastern Plants Toxic to Ruminants. Vet Clin N A Food Anim Pract 2011;27:447 [Web Reference]
Panter KE. Effects of Xenobiotics and Phytotoxins on Reproduction in Food Animals. Vet Clin N A Food Anim Pract 2011;27:429 [Web Reference]
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