BROMETHALIN TOXICITY IN DOGS AND CATS
 
Description    Bromethalin is a nonanticoagulant rodenticide thought to work by uncoupling mitochondrial oxidative phosphorylation in the central nervous system. This neurotoxin might cause acute or chronic signs if ingested.
 
Species   Canine, Feline
 
Signs   Abdominal distention, Abnormal behavior, aggression, changing habits, Abnormal hindlimb reflexes, Abnormal proprioceptive positioning, Abnormal pupillary response to light, Anisocoria, Anorexia, Arrhythmia, Ataxia, Blindness, Change in voice, Circling, Colic, Coma, Constant or increased vocalization, Cyanosis, Disoriented, Dullness, Dysmetria, Dyspnea, Dysuria, Enlarged, distended, urinary bladder, Excessive salivation, Excitement, Fever, Forelimb hypoesthesia, Forelimb spasms, Generalized weakness, Head pressing, Hindlimb hypoesthesia, Hyperesthesia, Inability to stand, Increased respiratory rate, Miosis, Nystagmus, Opisthotonus, Pain on external abdominal pressure, Pain, neck, cervical, throat, Paraparesis, Propulsion, Seizures or syncope, Sinus arrhythmia, Sudden death, Tachycardia, Tetraparesis, Trembling, Tremor, Urinary incontinence, Vomiting or regurgitation
 
References   Heggem-Perry B. Intravenous Lipid Emulsion Therapy for Bromethalin Toxicity in a Dog. JAAHA 2016;52:265 [Web Reference]
Bates MC. Atypical bromethalin intoxication in a dog: pathologic features and identification of an isomeric breakdown product. BMC Vet Res 2015;11:244 [Web Reference]
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