ORGANIC ARSENICAL, ARSANILIC ACID, ROXARSONE TOXICITY IN PIGS
 
Description    Organic arsenicals, derivatives of phenylarsonic acid such as arsanilic acid and roxarsone, have been used as growth stimulants and as treatments for swine dysentery. Excessive feeding can lead to onset of clinical signs. Signs are associated with degeneration of optic tracts, spinal tracts and peripheral nerves.
 
Species   Porcine
 
Signs   Abnormal proprioceptive positioning, Abnormal pupillary response to light, Anorexia, Ataxia, Blindness, Circling, Coma, Constant or increased vocalization, Decreased amount of stools, absent feces, constipation, Diarrhea, Dullness, Dysmetria, Excitement, Generalized weakness, Head tilt, Hyperesthesia, Inability to stand, Mucous, mucoid stools, feces, Mydriasis, Optic atrophy, Paraparesis, Rough hair coat, Seizures or syncope, Skin erythema, Tetraparesis, Torticollis, Trembling, Tremor
 
References   Middleton S. Porcine Ophthalmology. Vet Clin N A Food Anim Pract 2010;26:557 [Web Reference]
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