| LYMPHOSARCOMA, LYMPHOMA, LYMPHOID, MYELOPROLIFERATIVE LEUKEMIA, DISEASE | |
| Description | Lymphosarcoma can be generalized or localized as in the thymic or intestinal form. Hypercalcemia can accompany this tumor. Immune mediated hemolytic anemia and thrombocytopenia in horses with lymphosarcoma have been reported. There are reports of generalized lymphoma in aborted equine fetuses and in neonates. Primary or true leukemia without discrete mass lesions has been seen in which case the diagnosis is made by blood smear and/or bone marrow aspirate; affected cell lines have included lymphocytes, granulocytes, eosinophils, erythrocytes, and monocytes. |
| Species | Equine |
| Signs | Abdominal distention, Abnormal anal, perineal, tail reflexes, Abnormal breath odor, Abnormal breathing sounds of the upper airway, Abnormal corneal pigmentation, Abnormal lung or pleural sounds, Abnormal panniculus reflex, Abnormal proprioceptive positioning, Abnormal size testes/scrotum, Abortion or weak newborns, Agalactia, Alopecia, Anorexia, Arrhythmia, Ascites, Ataxia, Blepharospasm, Bloody stools, feces, hematochezia, Bradycardia, Chemosis, Colic, Congestion oral mucous membranes, Conjunctival, scleral, injection, Conjunctival, scleral, redness, Corneal edema, Corneal neovascularization, Corneal swelling, mass, nodule, plaque, Corneal ulcer, Coughing, Decreased amount of stools, absent feces, constipation, Decreased, muffled, lung sounds, Diarrhea, Dull areas on percussion of chest, thorax, Dullness on percussion sinus, Dullness, Dysmetria, Dysphagia, Dyspnea, Dysuria, Enlarged firm ovary, Enlarged, distended, urinary bladder, Enophthalmos, Epistaxis, Excessive salivation, Exercise intolerance, Exophthalmos, Female infertility, Fever, Forefoot pain, Forelimb atrophy, Forelimb lameness, Forelimb pain, Forelimb swelling, Forelimb weakness, Generalized lameness or stiffness, Generalized weakness, Grinding teeth, Head pressing, Head, face, ears, jaw weakness, droop, Head, face, ears, jaw, nose, nasal, swelling, Heart murmur, Hematuria, Hemoglobinuria or myoglobinuria, Hemorrhage of any body part or clotting failure, Hepatosplenomegaly, Hindfoot pain, Hindlimb lameness, Hindlimb swelling, Hyperesthesia, Hyphema, Icterus, Inability to stand, Increased frequency of urination, Increased respiratory rate, Ingesta in nasal passage, Internal abdominal mass, Jugular pulse, Lack of growth or weight gain, Lacrimation, Laryngeal, tracheal, pharyngeal swelling, Lymphadenopathy, Male infertility, Miosis, Mucoid nasal discharge, Muffled, decreased, heart sounds, Neck swelling, Neck, chest atrophy, Ocular pain, Oral cavity, tongue swelling, Oral mucosal ulcers, vesicles, Orbital, periorbital, periocular, conjunctival swelling, Pale, Palpable calculi, swelling or mass, bladder, Palpable precordial thrill, Paraparesis, Paraphimosis or priapism, Pelvic atrophy, Pelvic or perineal swelling, Peripheral venous distention, Petechiae or ecchymoses, Photophobia, Polydipsia, Polyuria, Prolonged capillary refill time, Pruritus, Ptosis, Purulent discharge from eye, Purulent nasal discharge, Red or brown urine, Reluctant to move, Rough hair coat, Seizures or syncope, Sinus arrhythmia, Skin crusts, Skin edema, Skin erythema, Skin pain, Skin scales, Skin ulcer, Sudden death, Swelling mass ovary, Swelling mass penis, prepuce, testes, scrotum, Swelling mass uterus, Swelling mass, vulva, clitoris, Swelling skin or subcutaneous, Tachycardia, Tetraparesis, Third degree, complete, atrioventricular heart block, Underweight, poor condition, thin, emaciated, unthriftiness, ill thrift, Urinary incontinence, Weak pulse, Weight loss |
| References | Montgomery JB et al. Pelvic lymphoma as a cause of urethral compression in a mare. Can Vet J 2009;50:751–754 [Web Reference] Kelton DR et al. Bone marrow necrosis and myelophthisis: manifestations of T-cell lymphoma in a horse. Veterinary Clinical Pathology 2008;37:403-408 [Web Reference] Sugiyama A et al. Mediastinal Lymphoma with Complete Atrioventricular Block in a Horse. Journal of Veterinary Medical Science 2008;70:1101-1105 [Web Reference] Morrison LR et al. Lymphoproliferative Disease with Features of Lymphoma in the Central Nervous System of a Horse. Journal of Comparative Pathology 2008;139:256-261 [Web Reference] Scase TJ. Classification of equine lymphoma. Equine Veterinary Education 2008;20:467-468 [Web Reference] Roberts MC. Equine lymphoma: What are the prospects for cellular differentiation, early diagnosis and intervention strategies? Equine Veterinary Education 2008;20:464-466 [Web Reference] Sheats MK et al. Disseminated large granular lymphoma in a horse. Equine Veterinary Education 2008;20:459-463 [Web Reference] Tornquist SJ. Bone Marrow and Lymph Node Evaluation. Veterinary Clinics of North America: Equine Practice 2008;24:261-283 [Web Reference] Jakesova V et al. Magnetic resonance imaging features of an extranodal T cell rich B cell lymphoma in the pharyngeal mucosa in a horse. Equine Veterinary Education 2008;20:289-293 [Web Reference] |