MAST CELL TUMOR, NEOPLASIA, MASTOCYTOMA, SYSTEMIC MASTOCYTOSIS IN DOGS AND CATS
 
Description    Canine and feline Mast Cell Tumors generally present as single or multiple skin lesions, sometimes accompanied by mast-cell leukemia. Cutaneous tumors range from soft and slow-growing to rapidly-enlarging and ulcerated. There can be sporadic appearance and disappearance of nonpigmented papules-to-wheals. Intestinal, ocular, visceral (e.g. hepatic and splenic), and laryngeal tumors also have been reported with or (rarely) without skin lesions. The visceral form is more common in cats than dogs and might be a separate form of the disease. Often associated with gastroduodenal ulcers in dogs.
 
Species   Canine, Feline
 
Signs   Abdominal distention, Abnormal upper airway breathing sounds, Alopecia, Anorexia, Ascites, Bloody stools, feces, hematochezia, Conjunctival, scleral, injection, Conjunctival, scleral, redness, Cyanosis, Decreased amount of stools, absent feces, constipation, Dehydration, Diarrhea, Dullness, Dyspnea, Exercise intolerance, Exophthalmos, Fever, Forefoot swelling, Forelimb swelling, Head, face, ears, jaw, nose, nasal, swelling, Hematemesis, Hemorrhage of any body part or clotting failure, Hepatosplenomegaly, Hindfoot swelling, Hindlimb swelling, Increased respiratory rate, Internal abdominal mass, Laryngeal, tracheal, pharyngeal swelling, Lymphadenopathy, Melena or occult blood in feces, stools, Oral cavity, tongue swelling, Orbital, periorbital, periocular, conjunctival swelling, Pain on external abdominal pressure, Pale, Polydipsia, Polyuria, Pruritus, Reluctant to move, Skin crusts, Skin edema, Skin erythema, Skin hyperpigmentation, Skin pain, Skin papules, Skin plaque, Skin scales, Skin ulcer, Skin wheal, Sudden death, Swelling mass penis, prepuce, testes, scrotum, spermatic cord, Swelling skin or subcutaneous, Underweight, poor condition, thin, emaciated, unthriftiness, ill thrift, Vomiting or regurgitation, Weight loss
 
References   Baginski H et al. The Prognostic Value of Lymph Node Metastasis with Grade 2 MCTs in Dogs: 55 Cases (20012010). Journal of the American Animal Hospital Association 2014;50:89-95 [Web Reference]
Kry KL, Boston SE. Additional Local Therapy With Primary Re-Excision or Radiation Therapy Improves Survival and Local Control After Incomplete or Close Surgical Excision of Mast Cell Tumors in Dogs. Veterinary Surgery 2014;43:182189 [Web Reference]
Zink MC et al. Evaluation of the risk and age of onset of cancer and behavioral disorders in gonadectomized Vizslas. Journal of the American Veterinary Medical Association 2014;244:309-319 [Web Reference]
Pratschke KM et al. Evaluation of a modified proportional margins approach for surgical resection of mast cell tumors in dogs: 40 cases (20082012). Journal of the American Veterinary Medical Association 2013;243:1436-1441 [Web Reference]
Amagai Y et al. Heterogeneity of internal tandem duplications in the c-kit of dogs with multiple mast cell tumours. Journal of Small Animal Practice 2013;54:377380 [Web Reference]
Bernstein JA et al. Moh`s micrographic surgery for the management of a periocular mast cell tumor in a dog. Veterinary Ophthalmology 2013;16:234239 [Web Reference]
Blackwood L. Cats with Cancer: Where to start. Journal of Feline Medicine and Surgery 2013;15:366-377 [Web Reference]
Oliveira FN et al. Cutaneous Mast Cell Tumor With Epitheliotropism in 3 Dogs. Vet Pathol 2013;50:234-237 [Web Reference]
Piviani M et al. Significance of mastocytemia in cats. Veterinary Clinical Pathology 2013;42:410 [Web Reference]
O`Connell K, Thomson M. Evaluation of prognostic indicators in dogs with multiple, simultaneously occurring cutaneous mast cell tumours: 63 cases. Veterinary and Comparative Oncology 2013;11:5162 [Web Reference]
Torres de la Riva G et al. Neutering Dogs: Effects on Joint Disorders and Cancers in Golden Retrievers. PLoS ONE 2013;8(2):e55937 [Web Reference]
Rivera P et al. Clinical efficacy and safety of a water-soluble micellar paclitaxel (Paccal Vet) in canine mastocytomas. Journal of Small Animal Practice 2013;54:20-27 [Web Reference]
Henry C, Herrera C. Mast Cell Tumors in Cats: Clinical update and possible new treatment avenues. Journal of Feline Medicine and Surgery 2013;15:41-47 [Web Reference]
Blackwood, L et al. European consensus document on mast cell tumours in dogs and cats. Veterinary and Comparative Oncology 2012;10:e1-e29 [Web Reference]
Copyright © 2014 Cornell University College of Veterinary Medicine