MAST CELL TUMOR, NEOPLASIA, MASTOCYTOMA, SYSTEMIC MASTOCYTOSIS IN DOGS AND CATS
 
Description    Mast Cell Tumors generally present as single or multiple skin lesions, sometimes accompanied by mast-cell leukemia. Cutaneous tumors range from soft and slow-growing to rapidly-enlarging and ulcerated. There can be sporadic appearance and disappearance of nonpigmented papules-to-wheals. Intestinal, ocular, visceral (e.g. hepatic and splenic), and laryngeal tumors also have been reported with or (rarely) without skin lesions. The visceral form is more common in cats than dogs and might be a separate form of the disease. Often associated with gastroduodenal ulcers in dogs.
 
Species   Canine, Feline
 
Signs   Abdominal distention, Abnormal upper airway breathing sounds, Alopecia, Anorexia, Ascites, Bloody stools, feces, hematochezia, Conjunctival, scleral, injection, Conjunctival, scleral, redness, Cyanosis, Decreased amount of stools, absent feces, constipation, Dehydration, Diarrhea, Dullness, Dyspnea, Exercise intolerance, Exophthalmos, Fever, Forefoot swelling, Forelimb swelling, Head, face, ears, jaw, nose, nasal, swelling, Hematemesis, Hemorrhage of any body part or clotting failure, Hepatosplenomegaly, Hindfoot swelling, Hindlimb swelling, Increased respiratory rate, Internal abdominal mass, Laryngeal, tracheal, pharyngeal swelling, Lymphadenopathy, Melena or occult blood in feces, stools, Oral cavity, tongue swelling, Orbital, periorbital, periocular, conjunctival swelling, Pain on external abdominal pressure, Pale, Polydipsia, Polyuria, Pruritus, Reluctant to move, Skin crusts, Skin edema, Skin erythema, Skin hyperpigmentation, Skin pain, Skin papules, Skin plaque, Skin scales, Skin ulcer, Skin wheal, Sudden death, Swelling mass penis, prepuce, testes, scrotum, spermatic cord, Swelling skin or subcutaneous, Underweight, poor condition, thin, emaciated, unthriftiness, ill thrift, Vomiting or regurgitation, Weight loss
 
References   Kraus KA. Outcome and Prognostic Indicators in Cats Undergoing Splenectomy for Splenic Mast Cell Tumors. Journal of the American Animal Hospital Association 2015;51:231-238 [Web Reference]
Burton JH. Pulse-Administered Toceranib Phosphate Plus Lomustine for Treatment of Unresectable Mast Cell Tumors in Dogs. Journal of Veterinary Internal Medicine 2015;29:10981104 [Web Reference]
Warland J. Canine mast cell tumours: decision-making and treatment. In Practice 2015;37:315-332 [Web Reference]
Risselada M. Surgically planned versus histologically measured lateral tumor margins for resection of cutaneous and subcutaneous mast cell tumors in dogs: 46 cases (2010–2013). Journal of the American Veterinary Medical Association 2015;247:184-189 [Web Reference]
Gil da Costa RM et al. C-kit as a prognostic and therapeutic marker in canine cutaneous mast cell tumours: From laboratory to clinic. The Veterinary Journal 2015;205:5-10 [Web Reference]
Melville K et al. Feline cutaneous mast cell tumours: a UK-based study comparing signalment and histological features with long-term outcomes. Journal of Feline Medicine and Surgery 2015;17:486-493 [Web Reference]
Berlato D et al. Comparison of mitotic index and Ki67 index in the prognostication of canine cutaneous mast cell tumours. Veterinary and Comparative Oncology 2015;13:143-150 [Web Reference]
Matz BM. Current Concepts in Oncologic Surgery in Small Animals. Veterinary Clinics of North America: Small Animal Practice 2015;45:437-449 [Web Reference]
Stefanello D et al. Comparison of 2- and 3-category histologic grading systems for predicting the presence of metastasis at the time of initial evaluation in dogs with cutaneous mast cell tumors: 386 cases (2009-2014. Journal of the American Veterinary Medical Association 2015;246:765-769 [Web Reference]
Donnelly L et al. Evaluation of histological grade and histologically tumour-free margins as predictors of local recurrence in completely excised canine mast cell tumours. Veterinary and Comparative Oncology 2015;13:70-76 [Web Reference]
Shales C. Management of non-lymphomatous small intestinal tumours in dogs and cats. In Practice 2015;37:50-67 [Web Reference]
Warland J et al. The utility of staging in canine mast cell tumours. Veterinary and Comparative Oncology 2014;12:287-298 [Web Reference]
Smith AN. The Role of Neutering in Cancer Development. Veterinary Clinics of North America: Small Animal Practice 2014;44:965-975 [Web Reference]
Hart BL et al. Long-Term Health Effects of Neutering Dogs: Comparison of Labrador Retrievers with Golden Retrievers. PLoS ONE 2014;9:e102241 [Web Reference]
Schwab TM et al. Clinical Outcome for MCTs of Canine Pinnae Treated with Surgical Excision (2004-2008). Journal of the American Animal Hospital Association 2014;50:187-191 [Web Reference]
Baginski H et al. The Prognostic Value of Lymph Node Metastasis with Grade 2 MCTs in Dogs: 55 Cases (2001-2010). Journal of the American Animal Hospital Association 2014;50:89-95 [Web Reference]
Kry KL, Boston SE. Additional Local Therapy With Primary Re-Excision or Radiation Therapy Improves Survival and Local Control After Incomplete or Close Surgical Excision of Mast Cell Tumors in Dogs. Veterinary Surgery 2014;43:182-189 [Web Reference]
Zink MC et al. Evaluation of the risk and age of onset of cancer and behavioral disorders in gonadectomized Vizslas. Journal of the American Veterinary Medical Association 2014;244:309-319 [Web Reference]
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