MAST CELL TUMOR, NEOPLASIA, MASTOCYTOMA, SYSTEMIC MASTOCYTOSIS IN DOGS AND CATS
 
Description    Mast Cell Tumors generally present as single or multiple skin lesions, sometimes accompanied by mast-cell leukemia. Cutaneous tumors range from soft and slow-growing to rapidly-enlarging and ulcerated. There can be sporadic appearance and disappearance of nonpigmented papules-to-wheals. Intestinal, ocular, visceral (e.g. hepatic and splenic), and laryngeal tumors also have been reported with or (rarely) without skin lesions. The visceral form is more common in cats than dogs and might be a separate form of the disease. Often associated with gastroduodenal ulcers in dogs.
 
Species   Canine, Feline
 
Signs   Abdominal distention, Abnormal upper airway breathing sounds, Alopecia, Anorexia, Ascites, Bloody stools, feces, hematochezia, Conjunctival, scleral, injection, Conjunctival, scleral, redness, Cyanosis, Decreased amount of stools, absent feces, constipation, Dehydration, Diarrhea, Dullness, Dyspnea, Exercise intolerance, Exophthalmos, Fever, Forefoot swelling, Forelimb swelling, Head, face, ears, jaw, nose, nasal, swelling, Hematemesis, Hemorrhage of any body part or clotting failure, Hepatosplenomegaly, Hindfoot swelling, Hindlimb swelling, Hyperkeratosis, Increased respiratory rate, Internal abdominal mass, Laryngeal, tracheal, pharyngeal swelling, Lymphadenopathy, Melena or occult blood in feces, stools, Oral cavity, tongue swelling, Orbital, periorbital, periocular, conjunctival swelling, Pain on external abdominal pressure, Pale, Polydipsia, Polyuria, Pruritus, Reluctant to move, Skin crusts, Skin edema, Skin erythema, Skin hyperpigmentation, Skin pain, Skin papules, Skin plaque, Skin scales, Skin ulcer, Skin wheal, Sudden death, Swelling mass penis, prepuce, testes, scrotum, spermatic cord, Swelling skin or subcutaneous, Underweight, poor condition, thin, emaciated, unthriftiness, ill thrift, Vomiting or regurgitation, Weight loss
 
References   Ferrari R. The impact of extirpation of non‐palpable/normal‐sized regional lymph nodes on staging of canine cutaneous mast cell tumours: A multicentric retrospective study. Vet Compar Oncol 2018;Jun [Web Reference]
Reagan JK. Evaluation of information presented within mast cell tumour histopathology reports in the United States: 20122015. Vet Med Sci 2018;Jun [Web Reference]
Ngo J. Feline maculopapular cutaneous mastocytosis: a retrospective study of 13 cases and proposal for a new classification. J Feline Med Surg 2018;Jun [Web Reference]
Olsen JA. Combination vinblastine, prednisolone and toceranib phosphate for treatment of grade II and III mast cell tumours in dogs. Vet Med Sci 2018;Jun [Web Reference]
Musser M. Marked paraneoplastic hypereosinophilia associated with a low-grade, metastatic canine mast cell tumour. Vet Rec Case Reports 2018;6:e000563 [Web Reference]
Blackwood L. Acute radiotherapy toxicity in 57 dogs with gross and microscopic mast cell tumours. Vet Compar Oncol 2018;May [Web Reference]
Shekell CC. Primary tonsillar mast cell tumour in a dog. Aust Vet J 2018;Apr [Web Reference]
Moirano SJ. Association of prognostic features and treatment on survival time of dogs with systemic mastocytosis: A retrospective analysis of 40 dogs. Vet Compar Oncol 2018;Apr [Web Reference]
Dores CB. Comparison of histologic margin status in low‐grade cutaneous and subcutaneous canine mast cell tumours examined by radial and tangential sections. Vet Compar Oncol 2018;Apr [Web Reference]
Pizzoni S. Features and prognostic impact of distant metastases in 45 dogs with de novo stage IV cutaneous mast cell tumours: A prospective study. Vet Compar Oncol 2018;Apr [Web Reference]
Evans BJ. Treatment outcomes and prognostic factors of feline splenic mast cell tumors: A multi‐institutional retrospective study of 64 cases. Vet Compar Oncol 2018;Apr [Web Reference]
Horta RS. Assessment of Canine Mast Cell Tumor Mortality Risk Based on Clinical, Histologic, Immunohistochemical, and Molecular Features. Vet Pathol 2018;Jan [Web Reference]
Berger EP. Retrospective evaluation of toceranib phosphate (Palladia) use in cats with mast cell neoplasia. J Feline Med Surg 2018;20:95 [Web Reference]
Milovancev M. Reductions in margin length after excision of grade II mast cell tumors and grade I and II soft tissue sarcomas in dogs. Vet Surg 2018;47:36 [Web Reference]
Case A. Safety and efficacy of intralesional triamcinolone administration for treatment of mast cell tumors in dogs: 23 cases (20052011). JAVMA 2018;252:84 [Web Reference]
Robinson WP. Intramuscular mast cell tumors in 7 dogs. Can Vet J 2017;58:931 [Web Reference]
Moirano SJ.. Association of prognostic features and treatment on survival time of dogs with systemic mastocytosis: A retrospective analysis of 40 dogs. Vet Comp Oncol 2017;Dec [Web Reference]
Campbell O. Presumptive primary pulmonary mast cell tumor in 2 dogs. Can Vet J 2017;58:591 [Web Reference]
Milovancev M. Surgical margins in the veterinary cancer patient. Vet Comp Oncol 2017;15:1136 [Web Reference]
Woldemeskel M. Significance of cytological smear evaluation in diagnosis of splenic mast cell tumor-associated systemic mastocytosis in a cat (Felis catus). Can Vet J 2017;58:293 [Web Reference]
Mochizuki H. Association of breed and histopathological grade in canine mast cell tumours. Vet Comp Oncol 2017;15:829 [Web Reference]
Lowe R. The treatment of canine mast cell tumours with electrochemotherapy with or without surgical excision. Vet Comp Oncol 2017;15:775 [Web Reference]
Copyright © 2018 Cornell University College of Veterinary Medicine