Description    Polycystic Kidney Disease (PKD) is a congenital disorder with disruption of renal parenchyma by cysts of various sizes that can predispose the kidney to infection or cause progressive renal failure. Seen in several breeds; might be familial in Cairn Terrier dogs and is inherited as an autosomal dominant in cats and Bull Terrier dogs. Enlarged kidneys are palpable. There can be associated cystic lesions in the liver. In the glomerulocystic manifestation of PKD the cysts are not detected in the kidney by ultrasonography.
Species   Canine, Feline
Signs   Abdominal distention, Abnormal breath odor, Anorexia, Ascites, Coma, Dehydration, Diarrhea, Dullness, Fever, Generalized weakness, Hematuria, Hypothermia, Increased respiratory rate, Internal abdominal mass, Lack of growth or weight gain, Oral mucosal ulcers, vesicles, Pain, kidney, ureters, on palpation, Pale, Palpable enlarged kidney , Polydipsia, Polyuria, Prolonged capillary refill time, Proteinuria, Red or brown urine, Sudden death, Tachycardia, Underweight, poor condition, thin, emaciated, unthriftiness, ill thrift, Vomiting or regurgitation, Weight loss
References   Nivy R. Polycystic kidney disease in four British shorthair cats with successful treatment of bacterial cyst infection. Journal of Small Animal Practice 2015;56:585589 [Web Reference]
Lyons LA. DNA mutations of the cat: The good, the bad and the ugly. Journal of Feline Medicine and Surgery 2015;17:203-219 [Web Reference]
Basile A et al. Juvenile Nephropathy in a Boxer Dog Resembling the Human Nephronophthisis-Medullary Cystic Kidney Disease Complex. J Vet Med Sci 2011;73:1669-1675 [Web Reference]
Kim J et al. Multicystic dysplastic kidney disease in a dog. Can Vet J 2011;52:645649 [Web Reference]
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