MYCOBACTERIUM AVIUM SUBSPECIES PARATUBERCULOSIS, JOHNE'S DISEASE
 
Description    MYCOBACTERIUM AVIUM subspecies PARATUBERCULOSIS causes infectious chronic granulomatous enteritis in ruminants. Calves are most susceptible to infection from birth to a few months of age but the incubation period prior to the onset of clinical signs generally ranges from 2 to 10 years. Fecal-oral transmission from cows to calves is believed to be the most common method of spread; also shed in milk and colostrum. Intrauterine infection can occur but does not appear to be of major importance in the transmission of paratuberculosis. Affected cattle continue to eat even as chronic diarrhea and weight loss persist. In goats the disease primarily affects the upper GI tract and weight loss might be the only obvious sign, with diarrhea intermittent or absent. Usually affects goats 2-years-old or older but yearlings can be affected. Paratuberculosis is common in flocks of sheep but identification of individual sheep with subclinical infections is difficult. Sheep might not show signs for years after being infected and there is often weight loss without other signs.
 
Species   Bovine, Caprine, Ovine
 
Signs   Agalactia, Alopecia, Anestrus, Anorexia, Dark color stools, feces, Dehydration, Diarrhea, Dryness of skin or hair, Dullness, Female infertility, Fever, Generalized weakness, Head, face, ears, jaw, nose, nasal, swelling, Inability to stand, Lack of growth or weight gain, Pale, Polydipsia, Polyphagia, Rough hair coat, Skin edema, Tachycardia, Underweight, poor condition, thin, emaciated, unthriftiness, ill thrift, Weight loss
 
References   Gautam M. Control of clinical paratuberculosis in New Zealand pastoral livestock. N Z Vet J 2018;66:1 [Web Reference]
Yamamoto T. Evaluation of fecal shedding and antibody response in dairy cattle infected with paratuberculosis using national surveillance data in Japan. Prev Vet Med 2018;149:38 [Web Reference]
Rathnaiah G. Pathogenesis, Molecular Genetics, and Genomics of Mycobacterium avium subsp. paratuberculosis, the Etiologic Agent of Johne’s Disease. Front Vet Sci 2017;Nov [Web Reference]
Serrano M. Preliminary Results Indicate That Inactivated Vaccine against Paratuberculosis Could Modify the Course of Experimental Mycobacterium bovis Infection in Calves. Front Vet Sci 2017;Oct [Web Reference]
McAloon CG. Relative importance of herd-level risk factors for probability of infection with paratuberculosis in Irish dairy herds. J Dairy Sci 2017;100:9245 [Web Reference]
Romdhane RB. Which phenotypic traits of resistance should be improved in cattle to control paratuberculosis dynamics in a dairy herd: a modelling approach. Vet Res 2017;48:62 [Web Reference]
Stonos N. Prevalence of small ruminant lentivirus and Mycobacterium avium subsp. paratuberculosis co-infection in Ontario dairy sheep and dairy goats. Can J Vet Res 2017;81:155 [Web Reference]
Schwarz DGG. Passive shedding of Mycobacterium avium ssp. paratuberculosis in commercial dairy goats in Brazil. J Dairy Sci 2017;100:8426 [Web Reference]
Li L. Identification of sero-reactive antigens for the early diagnosis of Johne’s disease in cattle. PLoS ONE 2017;12:e0184373 [Web Reference]
Roy GL. Experimental infection with Mycobacterium avium subspecies paratuberculosis resulting in decreased body weight in Holstein-Friesian calves. Can Vet J 2017;58:296 [Web Reference]
Pesqueira MN. Correlation between within-herd antibody-prevalence and bulk tank milk antibody levels to Mycobacterium avium ssp. paratuberculosis using 2 commercial immunoassays. J Dairy Sci 2017;100:7544 [Web Reference]
Beaver A. Longitudinal relationship between fecal culture, fecal quantitative PCR, and milk ELISA in Mycobacterium avium ssp. paratuberculosis-infected cows from low-prevalence dairy herds. J Dairy Sci 2017;100:7507 [Web Reference]
Botaro BG. Associations between paratuberculosis ELISA results and test-day records of cows enrolled in the Irish Johne`s Disease Control Program. J Dairy Sci 2017;100:7468 [Web Reference]
Rossi G. The effect of Mycobacterium avium ssp. paratuberculosis infection on clinical mastitis occurrence in dairy cows. J Dairy Sci 2017;100:7446 [Web Reference]
Thirunavukkarasu S. Applying the One Health Concept to Mycobacterial Research – Overcoming Parochialism. Zoonoses Pub Health 2017;64:401 [Web Reference]
Mathevon Y. Estimation of the sensitivity and specificity of two serum ELISAs and one fecal qPCR for diagnosis of paratuberculosis in sub-clinically infected young-adult French sheep using latent class Bayesian modeling. BMC Vet Res 2017;13:230 [Web Reference]
Kirkeby C. Epidemiological and economic consequences of purchasing livestock infected with Mycobacterium avium subsp. paratuberculosis. BMC Vet Res 2017;13:202 [Web Reference]
Begg DJ. Variation in susceptibility of different breeds of sheep to Mycobacterium avium subspecies paratuberculosis following experimental inoculation. Vet Res 2017;48:36 [Web Reference]
Corbett CS. Fecal shedding and tissue infections demonstrate transmission of Mycobacterium avium subsp. paratuberculosis in group-housed dairy calves. Vet Res 2017;48:27 [Web Reference]
Smith RL. Economic consequences of paratuberculosis control in dairy cattle: A stochastic modeling study. Prev Vet Med 2017;138:17 [Web Reference]
Mataragka A. Faecal shedding of Mycobacterium avium subspecies paratuberculosis reduces before parturition in sheep? Small Rumin Res 2017;147:32 [Web Reference]
Pritchard TC. Phenotypic effects of subclinical paratuberculosis (Johne’s disease) in dairy cattle. J Dairy Sci 2017;100:679 [Web Reference]
Laurin EL. Assessment of the relative sensitivity of milk ELISA for detection of Mycobacterium avium ssp. paratuberculosis infectious dairy cows. J Dairy Sci 2017;100:598 [Web Reference]
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