photo of student with pony  

Advancing the health
and well-being of
animals and people


Lisa Fortier

Dr. Lisa A. Fortier
Cornell University
College of Veterinary Medicine
C3 181 VMC, Box 34
Ithaca, NY 14853
laf4@cornell.edu

Fortier Laboratory

Cornell Ruffian Equine Specialists

Selected Publications


Fischer BL, Ludders JW, Asakawa M, Fortier LA, Fubini SL, Nixon AJ, Radcliffe RM, Erb HN. A comparison of epidural buprenorphine plus detomidine with morphine plus detomidine in horses undergoing bilateral stifle arthroscopy. Vet Anaesth Analg 2009, 36(1):67-76.

McCarrel T, Fortier LA. Temporal growth factor release from platelet-rich plasma, trehalose lyophilized platelets, and bone marrow aspirate and their effect on tendon and ligament gene expression. J Orthop Res 2009; epub ahead of print

Novakofski KD, Boehm AK, Fortier LA. The small GTPase Rho mediates articular chondrocyte phenotype and morphology in response to interleukin-1a and insulin-like growth factor-I. J Orthop Res 2008; in review as of April, 2008.

Schnabel LV, Mohammed HO, Jacobson MS, Fortier LA. Effects of platelet rich plasma and acellular bone marrow on gene expression patterns and DNA content of equine suspensory ligament explants cultures. Equine Vet J 2008; Jan 29 [Epub ahead of print].
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Fortier LA, Smith RK. Regenerative medicine for tendinous and ligamentous injuries of sport horses. Vet Clin North Am Equine Pract. 2008; 24:191-201.
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Watts AE, Fortier LA, Nixon AJ, Ducharme NG. A technique for internal fixation of scapulohumeral luxation using scapulohumeral tension sutures in three alpacas and one miniature steer. Vet Surg 2008; 37:161-165.
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Boehm AK, Seth M, Mayr KG, Fortier LA. Hsp90 mediates insulin-like growth factor 1 and interleukin-1beta signaling in an age-dependent manner in equine articular chondrocytes. Arthritis and Rheum 2007; 56:2335-2343.
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Fortier LA, Schnabel LV, Mohammed HO, Mayr KG. Assessment of cartilage degradation effects of matrix metalloproteinase-13 in equine cartilage cocultured with synovicytes. Am J Vet Res 2007; 68:379-384.
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Schnabel LV, Mohammed HO, Miller BJ, McDermott WG, Jacobson MS, Santangelo KS, Fortier LA. Platelet rich plasma (PRP) enhances anabolic gene expression patterns in flexor digitorum superficialis tendons. J Orthop Res 2007; 25:230-240.
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Semevolos SA, Nixon AJ, Fortier LA, Strassheim ML, Haupt J. Age-related expression of molecular regulators of hypertrophy and maturation in articular cartilage. J Orthop Res 2006; 24:1773-1781.
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Fortier LA and Miller BJ. Signaling through the small G-protein Cdc42 is involved in insulin-like growth factor-I resistance in aging articular chondrocytes. J Orthop Res 2006; 24:1765-1772.
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Gregg AJ, Fortier LA, Mohammed HO, Mayr KG, Miller BJ, Haupt JL. Assessment of the catabolic effects of interleukin-1beta on proteoglycan metabolism in equine cartilage cocultured with synoviocytes. Am J Vet Res 2006; 67:957-962.
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Gratz KR, Wong VW, Chen AC, Fortier LA, Nixon AJ, Sah RL. Biomechanical assessment of tissue retrieved after in vivo cartilage defect repair: tensile modulus of repair tissue and integration with host cartilage. J Biomech 2006; 39:138-146.
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Fortier LA, Nixon AJ. New surgical treatments for osteochondritis dissecans and subchondral bone cysts. Vet Clin North Am Equine Pract 2005; 21:547-557.
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Fortier LA. Systemic therapies for joint disease in horses. Vet Clin North Am Equine Pract 2005; 21:673-690, v. Review.
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Fortier LA. Stem Cells: Classifications, controversies and clinical applications. Vet Surg 2005; 34:415-423. Invited Review.
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Fortier LA. Indications and techniques for tenoscopic surgery of the digital sheath. Equine Vet Ed 2005; 17:218-224.

Fortier LA, Kornatowski MA, Mohammed HO, Jordan MT, O'Cain LC, Stevens IV, WB. Age-related changes in serum insulin-like growth factor-I, insulin-like growth factor-I binding protein-3 and articular cartilage structure in Thoroughbred horses. Equine Vet J 2005; 37:37-42.
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Fortier LA, Gregg AG, Fubini SL, Erb HN. Caprine obstructive urolithiasis: requirement for 2nd surgical intervention and mortality after percutaneous tube cystostomy, surgical tube cystostomy, or urinary bladder marsupialization Vet Surg 2004; 33:661-667.
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Nixon AJ, Fortier LA, Goodrich LR, Ducharme NG. Arthroscopic reattachment of osteochondritis dissecans lesions using resorbable polydioxanone pins. Equine Vet J 2004; 36:376-83.
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Fortier LA, Deak, MM, Semevolos SA, and Cerione RA. Insulin-like Growth Factor-I Diminishes the Activation Status and Expression of the Small GTPase Cdc42 in Articular Chondrocytes. J Orthop Res, 2004; 22(2):436-445.
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Textor JA, Nixon AJ, Fortier LA. Tenoscopic release of the carpal canal. Vet Surg, 2003; 23(3):278-284.
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Fortier LA, Nixon AJ, Lust G. Phenotypic expression of equine articular chondroytes grown in three-dimensional cultures supplemented with supraphysiologic concentrations of insulin-like growth factor-I. Am J Vet Res, 2002; 63(2):301-305.
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Goodrich LR, Nixon AJ, Fubini SL, Ducharme NG, Fortier LA, Ludders JW. The efficacy of epidurally administered morphine and detomidine in decreasing postoperative hindlimb lameness in horses following bilateral stifle arthroscopy. Vet Surg, 2002; 31(3):232-239.
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Fortier LA, Lust G, Mohammed HO, Nixon AJ. Insulin-like growth factor-I enhances cell-based articular cartilage repair. J Bone Joint Surg Br; 2002; 84(2):276-288.
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Fortier LA, Balkman CE, Sandell LJ, Ratcliffe A, Nixon AJ. Insulin-like growth factor-I gene expression patterns during spontaneous repair of acute articular cartilage injury. J Orthop Res 2001; 19(4): 720-728.
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Worster AA, Brower-Toland BD, Fortier LA, Bent SJ, Williams J, Nixon AJ. Chondrocytic differentiation of mesenchymal stem cells sequentially exposed to transforming growth factor-B1 in monolayer and insulin-like growth factor-I in three-dimensional matrix. J Orthop Res 2001; 19(4): 738-749.
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Fortier LA, Nixon AJ, Ducharme NG, Mohammed HO, Yeager A. Tenoscopic examination and palmar/plantar proximal annular ligament transection for equine "complex" tenosynovitis: Long-term follow-up and results in 26 horses. Vet Surg 1999; 28: 429-435.
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Nixon AJ, Mohammed HO, Williams J, Fortier LA. Enhanced repair of extensive articular defects by insulin-like growth factor-I laden fibrin composites. J Orthop Res 1999; 17: 475-487.
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Fortier LA, Lust G, Mohammed HO, Nixon AJ. Coordinate upregulation of cartilage matrix gene expression in fibrin cultures supplemented with exogenous insulin-like growth factor-I. J Orthop Res 1999; 17: 467-474.
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Fortier LA, Nixon AJ, Williams J, Cable CS. Isolation and chondrocytic differentiation of equine bone-marrow-derived mesenchymal stem cells. Am J Vet Res 1998; 59: 1182-1187.
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Fortier LA, Brofman PJ, Nixon AJ, Mohammed HO. Disparate chondrocyte metabolism in three-dimensional fibrin cultures derived from autogenous or commercially manufactured fibrinogen. Am J Vet Res 1997; 59: 514-520.
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Cable CS, Rebhun WC, Fortier LA. Cholelithiasis and cholecystitis in a dairy cow. J Am Vet Med 1997; 211: 899-900.
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Fortier LA, Nixon AJ. Distributional changes is substance-P nociceptive fiber patterns in naturally osteoarthritic articulations. J Rheum 1997; 24: 524-530.
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Fortier LA, Nixon AJ, Mohammed HO, Lust G. Altered biological activity of equine chondrocytes cultured in a three-dimensional fibrin matrix and supplemented with transforming growth factor β1. Am J Vet Res 1997; 58: 66-70.
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Fortier LA, Fubini SL, Flanders JA, Divers TJ. Guidelines for the diagnosis and surgical correction of equine and bovine congenital portosystemic shunts. Vet Surg 1996; 25: 154-160.
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Fortier LA, Foerner JJ, Nixon AJ. Arthroscopic removal of axial osteochondral fragments of the plantar/palmar proximal aspect of the proximal phalanx in horses: 119 cases (1988-1992). J Am Vet Med 1994; 206: 71-74.
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Fortier LA, MacHarg MA. Topical use of 5-fluorouracil for treatment of squamous cell carcinoma of the external genitalia of horses: 11 cases (1988-1992). J Am Vet Med 1994; 205: 1183-1185.
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Book Chapters

Pharmaceutical Management of Musculoskeletal Disorders. In Equine manual therapy: Chiropractic and osteopathic approaches to musculoskeletal health. Haussler, Robinson, eds. Elsevier, in press. 2005

Additional intraarticular therapies in Current Therapy in Equine Medicine 5. Robinson, ed. W.B. Saunders Co. 2002, pp 555-557.

Fortier LA. Hepatic Diseases in Foals - Portosystemic Shunts. In: Mair, Ducharme, Divers eds.: Manual of Equine Gastroenterology. Harcourt Brace & Co Ltd., London, UK. 2001. pp 513-516.