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Stephan Menne, PhD

Selected Publications

Menne, S., J. Maschke, T. Tolle, M. Lu, and M. Roggendorf. 1997. Characterization of T-cell response to woodchuck hepatitis virus core protein and protection of woodchucks from infection by immunization with peptides containing a T-cell epitope. J. Virol. 71:65-74.

Menne, S., J. Maschke, M. Lu, H. Grosse-Wilde, and M. Roggendorf. 1998. T-cell response to woodchuck hepatitis virus (WHV) antigens during acute self-limited WHV infection and convalescence and after viral challenge. J. Virol. 72:6083-6091.

Menne, S. and B.C. Tennant. 1999. Unraveling hepatitis B virus infection of mice and men (and woodchucks and ducks). Nature Med. 10:1125-1126.

Menne, S., C.A. Roneker, J.L. Gerin, P.J. Cote, and B.C. Tennant. 2002. Deficiencies in the acute-phase cell-mediated immune response to viral antigens are associated with development of chronic woodchuck hepatitis virus infection following neonatal inoculation. J. Virol. 76:1769-1780.

Menne, S., C.A. Roneker, B.E. Korba, J.L. Gerin, B.C. Tennant, and P.J. Cote. 2002. Immunization with surface antigen vaccine alone and after treatment with L-FMAU breaks humoral and cell-mediated immune tolerance in chronic woodchuck hepatitis virus infection. J. Virol. 76:5305-5314.

Menne, S., Y. Wang, S.D. Butler, J.L. Gerin, P.J. Cote, and B.C. Tennant. 2002. Real-time polymerase chain reaction assays for leucocyte CD and cytokine mRNAs of the Eastern Woodchuck (Marmota monax). Vet. Immunol. Immunopathol. 87/1-2:97-105.

Menne, S., C.A. Roneker, B.C. Tennant, B.E. Korba, J.L. Gerin, and P.J. Cote. 2002. Immunogenic effects of WHsAg vaccine in combination with antiviral therapy: breaking of humoral and cellular immune tolerance in chronic WHV infection. Intervirology. 45:237-250.

Lu, M., R. Klaes, S. Menne, W.H. Gerlich, B. Stahl, H.-P. Dienes, U. Drebber, and M. Roggendorf. 2003. Induction of antibodies to the preS region of surface antigens of woodchuck hepatitis virus (WHV) in chronic carrier woodchucks by immunizations with WHV surface antigens. J. Hepatol. 39:405-413.

Wang, Y., S. Menne, J.R. Jacob, B.C. Tennant, J.L. Gerin, and P.J. Cote. 2003. Role of type 1 versus type 2 immune responses in liver during the onset of chronic woodchuck hepatitis virus infection. Hepatology. 37:771-780.

Menne, S. and P.J. Cote. 2003. The woodchuck as an emerging animal model for immunopathogenesis and immunotherapy of human HBV infection. In: Recent Res. Devel. Virol. 5:117-141.

Wang, Y., S. Menne, B.H. Baldwin, B.C. Tennant, J.L. Gerin, and P.J. Cote. 2004. Kinetics of viremia and acute liver injury in relation to outcome of neonatal woodchuck hepatitis virus infection. J. Med. Virol. 72:406-415.

Korba, B.E., P.J. Cote, S. Menne, I. Toshkov, B.H. Baldwin, F.V. Wells, B.C. Tennant, and J.L. Gerin. 2004. Clevudine therapy with vaccine inhibits progression of chronic hepatitis and delays onset of hepatocellular carcinoma in chronic woodchuck hepatitis virus infection. Antivir. Therapy. 9:937-952

Wang, Y., J.R. Jacob, S. Menne, C. Bellezza, B.C. Tennant, J.L. Gerin, and P.J. Cote. 2004. Interferon--associated responses to woodchuck hepatitis virus infection in neonatal woodchucks and virus-infected hepatocytes. J. Viral Hepatitis. 11:404-417.

Tennant, B.C., I.A. Toshkov, S.F. Peek, J.R. Jacob, S. Menne, W.E. Hornbuckle, R.D. Schinazi, B.E. Korba, P.J. Cote, and J.L. Gerin. 2004. Hepatocellular carcinoma in the woodchuck model of hepatitis B virus infection. Gastroenterology. 127 (5 Suppl 2):283-293.

Menne, S., P.J. Cote, B.E. Korba, S.D. Butler, A.L. George, I.A. Toshkov, W.E. Delaney IV, J.L. Gerin, and B.C. Tennant. 2005. Antiviral effect of oral administration of tenofovir disoproxil fumarate in woodchucks with chronic woodchuck hepatitis virus infection. Antimicrob. Agents Chemother. 49:2720-2728.

Menne, S. and P.J. Cote. 2007. The woodchuck as an animal model for pathogenesis and therapy of chronic hepatitis B virus infection. World J. Gastroenterology. 13:104-124.

Menne, S., P.J. Cote, S.D. Butler, I.A. Toshkov, J.L. Gerin, and B.C. Tennant. 2007. Immunosuppression reactivates viral replication long after resolution of woodchuck hepatitis virus infection. Hepatology. 45:614-622.

Ochoa-Callejero, L., P. Berraondo, J. Crettaz, C. Olague, A. Vales, J. Ruiz, J. Prieto, B.C. Tennant, S. Menne, and G. Gonzalez-Aseguinolaza. 2007. Woodchuck dendritic cells generated from peripheral blood mononuclear cells and transduced with recombinant human adenovirus serotype 5 induce antigen-specific cellular immune responses. J. Med. Virol. 79:522-529.

Lu, M., S. Menne, D. Yang, Y. Xu, and M. Roggendorf. 2007. Immunomodulation as an option for treatment of chronic hepatitis B virus infection: preclinical studies in the woodchuck model. Expert Opin. Investig. Drugs. 16:787-801.