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Characterization of T-cell response to woodchuck hepatitis virus core protein and
protection of woodchucks from infection by immunization with peptides containing a
T-cell epitope. J. Virol. 71:65-74.
Menne, S., J. Maschke, M. Lu, H. Grosse-Wilde, and M. Roggendorf. 1998. T-cell
response to woodchuck hepatitis virus (WHV) antigens during acute self-limited
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Menne, S. and B.C. Tennant. 1999. Unraveling hepatitis B virus infection of mice
and men (and woodchucks and ducks). Nature Med. 10:1125-1126.
Menne, S., C.A. Roneker, J.L. Gerin, P.J. Cote, and B.C. Tennant. 2002.
Deficiencies in the acute-phase cell-mediated immune response to viral antigens are
associated with development of chronic woodchuck hepatitis virus infection
following neonatal inoculation. J. Virol. 76:1769-1780.
Menne, S., C.A. Roneker, B.E. Korba, J.L. Gerin, B.C. Tennant, and P.J. Cote.
2002. Immunization with surface antigen vaccine alone and after treatment with
L-FMAU breaks humoral and cell-mediated immune tolerance in chronic
woodchuck hepatitis virus infection. J. Virol. 76:5305-5314.
Menne, S., Y. Wang, S.D. Butler, J.L. Gerin, P.J. Cote, and B.C. Tennant. 2002.
Real-time polymerase chain reaction assays for leucocyte CD and cytokine
mRNAs of the Eastern Woodchuck (Marmota monax). Vet. Immunol.
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Menne, S., C.A. Roneker, B.C. Tennant, B.E. Korba, J.L. Gerin, and P.J. Cote. 2002. Immunogenic effects of WHsAg vaccine in combination with antiviral therapy: breaking of humoral and cellular immune tolerance in chronic WHV infection. Intervirology. 45:237-250.
Lu, M., R. Klaes, S. Menne, W.H. Gerlich, B. Stahl, H.-P. Dienes, U. Drebber, and M. Roggendorf. 2003. Induction of antibodies to the preS region of surface antigens of woodchuck hepatitis virus (WHV) in chronic carrier woodchucks by immunizations with WHV surface antigens. J. Hepatol. 39:405-413.
Wang, Y., S. Menne, J.R. Jacob, B.C. Tennant, J.L. Gerin, and P.J. Cote. 2003.
Role of type 1 versus type 2 immune responses in liver during the onset of chronic
woodchuck hepatitis virus infection. Hepatology. 37:771-780.
Menne, S. and P.J. Cote. 2003. The woodchuck as an emerging animal model for
immunopathogenesis and immunotherapy of human HBV infection. In: Recent Res.
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Wang, Y., S. Menne, B.H. Baldwin, B.C. Tennant, J.L. Gerin, and P.J. Cote.
2004. Kinetics of viremia and acute liver injury in relation to outcome of neonatal
woodchuck hepatitis virus infection. J. Med. Virol. 72:406-415.
Korba, B.E., P.J. Cote, S. Menne, I. Toshkov, B.H. Baldwin, F.V. Wells, B.C.
Tennant, and J.L. Gerin. 2004. Clevudine therapy with vaccine inhibits progression
of chronic hepatitis and delays onset of hepatocellular carcinoma in chronic
woodchuck hepatitis virus infection. Antivir. Therapy. 9:937-952
Wang, Y., J.R. Jacob, S. Menne, C. Bellezza, B.C. Tennant, J.L. Gerin, and P.J. Cote. 2004. Interferon--associated responses to woodchuck hepatitis virus infection in neonatal woodchucks and virus-infected hepatocytes. J. Viral Hepatitis. 11:404-417.
Tennant, B.C., I.A. Toshkov, S.F. Peek, J.R. Jacob, S. Menne, W.E. Hornbuckle, R.D. Schinazi, B.E. Korba, P.J. Cote, and J.L. Gerin. 2004. Hepatocellular carcinoma in the woodchuck model of hepatitis B virus infection. Gastroenterology. 127 (5 Suppl 2):283-293.
Menne, S., P.J. Cote, B.E. Korba, S.D. Butler, A.L. George, I.A. Toshkov, W.E. Delaney IV, J.L. Gerin, and B.C. Tennant. 2005. Antiviral effect of oral administration of tenofovir disoproxil fumarate in woodchucks with chronic woodchuck hepatitis virus infection. Antimicrob. Agents Chemother. 49:2720-2728.
Menne, S. and P.J. Cote. 2007. The woodchuck as an animal model for pathogenesis and therapy of chronic hepatitis B virus infection. World J. Gastroenterology. 13:104-124.
Menne, S., P.J. Cote, S.D. Butler, I.A. Toshkov, J.L. Gerin, and B.C. Tennant. 2007. Immunosuppression reactivates viral replication long after resolution of woodchuck hepatitis virus infection. Hepatology. 45:614-622.
Ochoa-Callejero, L., P. Berraondo, J. Crettaz, C. Olague, A. Vales, J. Ruiz, J. Prieto, B.C. Tennant, S. Menne, and G. Gonzalez-Aseguinolaza. 2007. Woodchuck dendritic cells generated from peripheral blood mononuclear cells and transduced with recombinant human adenovirus serotype 5 induce antigen-specific cellular immune responses. J. Med. Virol. 79:522-529.
Lu, M., S. Menne, D. Yang, Y. Xu, and M. Roggendorf. 2007. Immunomodulation as an option for treatment of chronic hepatitis B virus infection: preclinical studies in the woodchuck model. Expert Opin. Investig. Drugs. 16:787-801.
S. Menne, P.J. Cote, S.D. Butler, A.L. George, G. Asif, S. Hurwitz, R.F. Schinazi, D.C.K. Chu, J.L. Gerin, and B.C. Tennant. 2007. Antiviral effect of orally administered aminopurine dioxolane in woodchucks with chronic woodchuck hepatitis virus infection. Antimicrob. Agents Chemother. 51:3177-3184.
S. Menne, B.C. Tennant, J.L. Gerin, and P.J. Cote. 2007. Chemo-immunotherapy of chronic hepatitis B virus infection in the woodchuck model breaks immunologic tolerance and restores T cell responses to preS- and S-regions of the viral envelope protein. J. Virol. 81:10614-10624.
S. Menne, P.J. Cote, S.D. Butler, A.L. George, I.A. Tochkov, Y. Zhu, S. Xiong. J.L. Gerin, and B.C. Tennant. 2008. Antiviral effect of orally administered lamivudine, emtricitabine, adefovir dipivoxil, and tenofovir disoproxil fumarate, alone and in combination in woodchucks with chronic woodchuck hepatitis virus infection. Antimicrob. Agents Chemother. 52:3617-3632.
Glebe, D., H. Lorenz, W.H. Gerlich, S.D. Butler, B.C. Tennant, P.J. Cote, and S. Menne. 2009. Correlation of virus and host response markers with circulating immune complexes during acute and chronic woodchuck hepatitis virus infection. J. Virol. 83:1579-1591.
Crettaz, J., I. Otano, L. Ochoa, A. Benito, A. Paneda, P. Berraondo, J.R. Madoz, A. Astudillo, S. Kochanek, J. Ruiz, S. Menne, J. Prieto, and G. Gonzalez-Aseguinolaza. 2009. Treatment of chronic viral hepatitis in woodchucks by prolonged intrahepatic expression of interleukin-12. J. Virol. 83:2663-2674.
Cote, P.J., S.D. Butler, A.L. George, J. Fairman, J.L. Gerin, B.C. Tennant, and S. Menne. 2009. Rapid immunity to vaccination with woodchuck hepatitis virus surface antigen using cationic liposome-DNA complexes as adjuvant. J. Med. Virol. 81:1760-1772.
Rodriguez-Madoz, J.R., K.H. Liu, J.I. Quetglas, M. Ruiz-Guillen, I. Otano, J. Crettaz, S.D. Butler, C.A. Bellezza, N.L. Dykes, B.C. Tennant, J. Prieto, G. González-Aseguinolaza, C. Smerdou, and S. Menne. 2009. Semliki forest virus expressing IL-12 induces antiviral and antitumoral responses in woodchucks with chronic viral hepatitis and HCC. J. Virol. 83:12266-12278.
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