photo of student with pony  

Advancing the health and well-being of animals and people

Rory J. Todhunter, BVSc, PhD

Rory J. Todhunter
Cornell University
College of Veterinary Medicine
C3 185 VMC, Box 32
Ithaca, NY 14853

Selected Publications

Duan F, Ogden D, Xu L, Liu K, Lust G, Sandler J, Dykes NL, Zhu L, Todhunter RJ, Zhang Z: Principal component analysis illustrates separate and related phenotypes for canine hip dysplasia and improves statistical power for association mapping. J Applied Statistics 2012 DOI:10.1080/02664763.2012.7406172012

Zhu L, Chen S, Jiang Z, Zhang Z, Harris S, Lust G, Jones P, Todhunter RJ: Identification of quantitative trait loci for canine hip dysplasia by two sequential linkage analyses. J Applied Statistics 2012; 39(8),1719-1731

Ogden DM, Scrivani PV, Dykes N, Lust G, Friedenberg SG, Todhunter RJ. The S-Measurement in the Diagnosis of Canine Hip Dysplasia. Vet Surg. 2011 Sep 14. doi: 10.1111/j.1532-950X.2011.00874.x. [Epub ahead of print]
PubMed abstract

Friedenberg SG, Zhu L, Zhang Z, Foels WB, Schweitzer PA, Wang W, Fisher PJ, Dykes NL, Corey E, Vernier-Singer M, Jung SW, Sheng X, Hunter LS, McDonough SP, Lust G, Bliss SP, Krotscheck U, Gunn TM, Todhunter RJ. Evaluation of a fibrillin 2 gene haplotype associated with hip dysplasia and incipient osteoarthritis in dogs. Am J Vet Res. 2011 Apr;72(4):530-40. PubMed abstract

Vanden Berg-Foels WS, Schwager SJ, Todhunter RJ, Reeves AP. Femoral head shape differences during development may identify hips at risk of degeneration. Ann Biomed Eng. 2011 Dec; 39(12): 2955-63. Epub 2011 Sep 10. PMID:21909817 [PubMed - in process]

Vanden Berg-Foels WS, Schwager SJ, Todhunter RJ, Reeves AP. Femoral Head Bone
Mineral Density Patterns May Identify Hips at Risk of Degeneration. Ann Biomed
Sep 16, 2010. PubMed abstract

Zhou Z, Sheng X, Zhang Z, Zhao K, Zhu L, Guo G, Friedenberg SG, Hunter LS, Vandenberg-Foels WS, Hornbuckle WE, Krotscheck U, Corey E, Moise NS, Dykes NL, Li J, Xu S, Du L, Wang Y, Sandler J, Acland GM, Lust G, Todhunter RJ. Differential genetic regulation of canine hip dysplasia and osteoarthritis. PLos One. 2010 Oct 11;5(10):e13219. PubMed abstract

Zhang Z, Ersoz E, Lai CQ, Todhunter RJ, Tiwari HK, Gore MA, Bradbury PJ, Yu J,
Arnett DK, Ordovas JM, Buckler ES. Mixed linear model approach adapted for
genome-wide association studies. Nat Genet. 42(4):355-60, 2010.PubMed abstract

Hou Y, Wang Y, Lust G, Zhu L, Zhang Z, Todhunter RJ. Retrospective analysis
for genetic improvement of hip joints of cohort labrador retrievers in the United
States: 1970-2007. PLoS One. 5(2):e9410, Feb 24, 2010. PubMed abstract

Phavaphutanon J, Mateescu RG, Tsai KL, Schweitzer PA, Corey EE, Vernier-Singer
MA, Williams AJ, Dykes NL, Murphy KE, Lust G, Todhunter RJ. Evaluation of
quantitative trait loci for hip dysplasia in Labrador Retrievers. Am J Vet Res. 70(9):1094-101, 2009. PubMed abstract

Boyko AR, Boyko RH, Boyko CM, Parker HG, Castelhano M, Corey L, Degenhardt JD,
Auton A, Hedimbi M, Kityo R, Ostrander EA, Schoenebeck J, Todhunter RJ, Jones P,
Bustamante CD. Complex population structure in African village dogs and its
implications for inferring dog domestication history. Proc Natl Acad Sci U S A. 106(33):13903-8, 2009.PubMed abstract

Zhang Z, Zhu L, Sandler J, Friedenberg SS, Egelhoff J, Williams AJ, Dykes NL,
Hornbuckle W, Krotscheck U, Moise NS, Lust G, Todhunter RJ. Estimation of
heritabilities, genetic correlations, and breeding values of four traits that
collectively define hip dysplasia in dogs. Am J Vet Res. 70(4):483-92, 2009. PubMed abstract

Castelhano MG, Acland GM, Ciccone PA, Corey EE, Mezey JG, Schimenti JC,
Todhunter RJ. Development and use of DNA archives at veterinary teaching
hospitals to investigate the genetic basis of disease in dogs. J Am Vet Med
. 234(1):75-80, 2009. PubMed abstract

Mateescu RG, Burton-Wurster NI, Tsai K, Phavaphutanon J, Zhang Z, Murphy KE,
Lust G, Todhunter RJ. Identification of quantitative trait loci for
osteoarthritis of hip joints in dogs. Am J Vet Res. 69(10):1294-300, 2008. PubMed abstract

Zhu L, Zhang Z, Schweitzer P, Phavaphutanon J, Vernier-Singer M, Corey E, Friedenberg S, Mateescu R, Williams A, Lust G, Acland G, Todhunter R. Refined quantitative trait loci intervals for hip joint laxity in dogs. Anim Genetics, 39(2):141-6, 2008. PubMed abstract

Winegardner KR, Scrivani PV, Krotscheck U, Todhunter RJ. Magnetic resonance imaging of subarticular bone marrow lesions in dogs with stifle lameness. Vet Radiol Ultrasound 48(4):312-317, 2007. PubMed abstract

Liu T, Todhunter RJ, Wu S, Hou W, Mateescu R, Zhang Z, Burton-Wurster NI, Acland GM, Lust G, Wu R. A random model for mapping imprinted quantitative trait loci in a structured pedigree: an implication for mapping canine hip dysplasia. Genomics 90(2):276-284, 2007. PubMed abstract

Hays L, Zhang Z, Mateescu RG, Lust G, Burton-Wurster NI, Todhunter RJ: Quantitative genetics of secondary hip joint osteoarthritis in a Labrador Retriever-Greyhound pedigree. Am J Vet Res 68(1):35-41, 2007. PubMed abstract

VandenBerg-Foels WS, Todhunter RJ, Schwager SJ, Reeves AP: Effect of early postnatal body weight on femoral head ossification onset and hip osteoarthritis in a canine model of developmental dysplasia of the hip. Pediatr Res 60(5):549-554, 2006. PubMed abstract

Chalmers HJ, Dykes NL, Lust G, Farese JP, Burton-Wurster NI, Williams AJ, Todhunter RJ: Assessment of bone mineral density of the femoral head in dogs with early osteoarthritis. Am J Vet Res 67(5):796-800, 2005. PubMed abstract

Todhunter RJ, Mateescu R, Lust G, Burton-Wurster NI, Dykes NL, Bliss SP, Williams AJ, Vernier-Singer M, Corey E, Harjes C, Quaas RL, Zhang Z, Gilbert RO, Volkmann D, Casella G, Wu R, Acland GM: Quantitative trait loci for hip dysplasia in a crossbreed pedigree. Mamm Genome 16(9):720-730, 2005. PubMed abstract

Mateescu R, Todhunter RJ, Lust G, Burton-Wurster N: Increased MIG-6 mRNA transcripts in osteoarthritic cartilage. Biochem Biophys Res Commun 332(2):482-486, 2005. PubMed abstract

Steffey MA, Miura N, Todhunter RJ, Nykamp SG, Freeman KP, Scarpino V, Vernier-Singer MA, Erb HN, MacLeod JN, Lust G, Burton-Wurster N: The potential and limitations of cartilage-specific (V+C)(-) fibronectin and cartilage oligomeric matrix protein as osteoarthritis biomarkers in canine synovial fluid. Osteoarthritis Cartilage 12(10):818-825, 2004. PubMed abstract

Todhunter RJ, Bertram JE, Smith S, et al. Effect of dorsal hip loading, sedation, and general anesthesia on dorsolateral subluxation score in dogs. Vet Surgery 32(3): 196-205, 2003. PubMed abstract

Todhunter RJ, Grohn YT, Bliss SP, Wilfand A, Williams AJ, Vernier-Singer M, Burton-Wurster N, Dykes NL, Wu R, Casella G, Acland GM, Lust G: Evaluation of multiple radiographic predictors of cartilage lesions in the hip joints of 8-month-old dogs. Am J Vet Res 64:1472-1478, 2003. PubMed abstract

Kennedy S, Lee DV, Bertram JEA, Bliss SP, Williams AJ, Soderholm V, Lust GL, Todhunter RJ: Analysis of ground reaction forces from serial force platforms in dogs with normal and osteoarthritic hips. Vet Comp Orthop Traumatol 16:170-177, 2003.

Todhunter RJ, Bliss SP, Casella G, Wu R, Lust G, Burton-Wurster NI, Williams AJ, Gilbert RO, Acland G. Genetic structure of susceptibility traits for hip dysplasia and microsatellite informativeness of an outcrossed canine pedigree. J Hered 94:39-48, 2003. PubMed abstract

Lou X-Y, Todhunter RJ, Lin M, Lu Q, Liu T, Bliss SP, Casella G, Acland GM, Lust G, Wu R. The extent and distribution of linkage disequilibrium in canine. Mamm Gen. Aug;14(8):555-64, 2003. PubMed abstract

Bliss S, Todhunter RJ, Quaas R, Casella G, Wu R, Lust G, Williams AJ, et al. Quantitative genetics of traits associated with canine hip dysplasia in a canine pedigree constructed by mating dysplastic Labrador Retrievers and unaffected Greyhounds. Am J Vet Res 63:1029-1035, 2002. PubMed abstract

Lust G, Todhunter RJ, Erb HN, Dykes NL, Williams AJ, Burton-Wurster NI, Farese JP: Comparison of three radiographic methods for diagnosis of hip dysplasia in eight-month-old dogs. J Am Vet Med Assoc 219(9):1242-1246, 2001. PubMed abstract

Lust G, Todhunter RJ, Erb HN, Dykes NL, Williams AJ, Burton-Wurster NI, Farese JP: Repeatability of dorsolateral subluxation scores in dogs and correlation with macroscopic appearance of hip osteoarthritis. Am J Vet Res 62(11):1711-1715, 2001. PubMed abstract

Todhunter RJ, Acland GM, Olivier M, et al: An outcrossed canine pedigree for linkage analysis of hip dysplasia. J Heredity 90(1):83-92, 1999.

Farese JP, Lust G, Williams AJ, Dykes NL, Todhunter RJ: Dorsolateral subluxation of femoral heads and distraction laxity for evaluation of canine hip joints. Am J Vet Res 60:1571-1576, 1999. PubMed abstract

Burton-Wurster N, Farese JP, Todhunter RJ, Lust G: Site-specific variation in femoral head cartilage composition in dogs at high and low risk for development of osteoarthritis: Insights into lesion formation. Osteoarthritis Cart 7:486-497, 1999. PubMed abstract

Lee DV, Bertram JEA, Todhunter RJ: Acceleration and balance in trotting dogs. J Exp Biol 202(Pt 24):3565-3573, 1999. PubMed abstract

Todhunter RJ, Acland GM, Olivier M, Williams AJ, Vernier-Singer M, Burton-Wurster N, Farese JP, Gröhn YT, Gilbert RO, Dykes NL, Lust G: An outcrossed canine pedigree for linkage analysis of hip dysplasia. J Hered 90(1):83-92, 1999. PubMed abstract

Farese JP, Todhunter RJ, Lust G et al.: Dorsolateral subluxation of hip joints measured in a weight-bearing position with radiography and computed tomography in dogs. Vet Surg 27:393-405, 1998. PubMed abstract