photo of student with pony  

Advancing the health and well-being of animals and people

Joe Wakshlag

Joseph J. Wakshlag
Cornell University
College of Veterinary Medicine
C1 120 VMC, Box 33
Ithaca, NY 14853
P (607) 253-4389
F (607) 253-3534

Cornell University Hospital for Animals
Nutrition Service

Cornell University Hospital for Animals
Sports & Rehabilitation Medicine Service

Selected Publications

Wakshlag J, Shmalberg J. Nutrition for Working and Service Dogs. Vet Clin North Am Small Anim Pract. 2014 Jul;44(4):719-740. doi: 10.1016

Loftus JP, Cavatorta D, Bushey JJ, Levine CB, Sevier CS, Wakshlag JJ. The 5-lipoxygenase inhibitor tepoxalin induces oxidative damage and altered PTEN status prior to apoptosis in canine osteosarcoma cell lines.  Vet Comp Oncol. 2014 May 12. doi: 10.1111/vco.12094. [Epub ahead of print]

Gagne JW, Wakshlag JJ, Simpson KW, Dowd SE, Latchman S, Brown DA, Brown K, Swanson KS, Fahey GC Jr.   Effects of a synbiotic on fecal quality, short-chain fatty acid concentrations, and the microbiome of healthy racing sled dogs.  BMC Vet Res. 2013 Dec 5;9:246. doi: 10.1186/1746-6148-9-246.  PMID: 24313995

Stadler SC, Vincent CT, Fedorov VD, Patsialou A, Cherrington BD, Wakshlag JJ, Monahan S, Zee BM, Zhang X, Garcia BA, Condeelis J, Brown AM, Coonrod SA, Allis CD. Dysregulation of PAD4-mediated citrullination of nuclear GSK3β activates TGF-β signaling and induces epithelial-to-mesenchymal transition in breast cancer cells. Proc Natl Acad Sci U S A. 2013 Jul 16;110(29):11851-6. PMID: 23818587

Helmerick EC, Loftus JP, Wakshlag JJ.The effects of baicalein on canine osteosarcoma cell proliferation and death.  Vet Comp Oncol. 2012 Dec 10. doi: 10.1111/vco.12013. PMID: 23228048

Yazwinski M, Milizio JG, Wakshlag JJ. Assessment of serum myokines and markers of inflammation associated with exercise in endurance racing sled dogs. J Vet Intern Med. 2013 Mar-Apr;27(2):371-6. PMID: 23398265

Streeter RL, Divers TJ, Mittel LA, Korn AE, Wakshlag JJ.  Selenium deficiency associations with gender, breed, serum vitamin E and creatine kinase, clinical signs, and diagnoses in horses of different age groups: a retrospective examination 1996-2011. Equine Vet J Suppl. 2012 Dec;(43):31-5. PMID: 23447875

Johnston AN, Center SA, McDonough SP, Wakshlag JJ, Warner KL.  Hepatic Copper concentrations in Labrador Retrievers with and without chronic hepatitis 72 cases (1980-2008). 2013 Feb 1;242(3):372-80 PMID: 23327181

Blackstock KJ, Schoeffler G, Wakshlag JJ, Diep AN, Bauer JE. Transient hyperlipidemia in a litter of kittens,  J Vet Emerg Crit Care Med, 2012 Dec;22(6):703-9. doi: 10.1111/j.1476-4431.2012.00797.x. Epub 2012 Oct 30. PMID: 23110600

Cherrington BD, Monahan S, Diep AN, Fleiss R, Sudilovsky D, Anguish LJ, Coonrod SA, Wakshlag JJ.  Comparative analysis of PAD-2 expression in canine, feline and human mammary tumours.  J Comp Pathol. 2012 Apr 18. 2012 Aug-Oct;147(2-3):139-46. PMID: 22520816

Center SA, Warner KL, Randolph JF, Wakshlag JJ. Sunvold, G. Resting energy expenditure per lean body mass determined by indirect calorimetry and bioelectrical impedance analysis in cats. J Vet Int Med., 2011 Nov-Dec;25(6):1341-50

Goupil RC, Bushey JJ, Kennedy-Peters J, Wakshlag JJ.  Prevalence of 5-lipoxygenase expression in canine osteosarcoma and the effects of a dual 5-lipoxygenase/cycloxygenase inhibitor on osteosarcoma cells in-vitro and in-vivo.  J Vet Path.  2012 Sep;49(5):802-10. PMID: 22287649

Wakshlag JJ, Struble AM, Simpson KW, Dowd SE.  Negative fecal characteristics are associated with pH and fecal flora alterations during dietary change in dogs. Int J App Res Vet Med, 2011, 9(3): 278-283.

Warren BS, Wakshlag JJ, Maley M, Farrell TJ, Struble AM, Panasevich MR, Wells MT. Use of pedometers to measure the relationship of dog walking to body condition score in obese and non-obese dogs. Br J Nutr. 2011; 106: S85-89

Heuberger R, Wakshlag J. Characteristics of ageing pets and their owners: dogs v. cats.  Br J Nutr. 2011; 106: S150-153.

Wakshlag JJ, Struble AM, Levine CB, Bushey JJ, LaFlamme DP, Long GM.  The effects of weight loss on adipokines and markers of inflammation in dogs.  Br J Nutr. 2011; 106: S11-14.  PMID: 22005402

Wakshlag JJ, Malone EM, Rassnick KM, Struble AM, Vacchiani P, Trump DL, Tiam L.  Cross-sectional study to investigate the association between vitamin D status and cutaneous mast cell tumours in Labrador Retrievers. Br J Nutr. 2011; S60-63.

Wakshlag JJ, Struble AM, Warren BS, Maley M, Panasevich MR, Cummings KJ, Long GM, Laflamme DE.  Evaluation of dietary energy intake and physical activity in dogs undergoing a controlled weight-loss program.  J Am Vet Med Assoc.  2012 Feb 15;240(4):413-9. PMID: 22309013

Wakshlag JJ, Kennedy-Peters J, Bushey JJ, Loftus JP.  5-lipoxygenase expression and tepoxalin-induced cell death in squamous cell carcinomas in cats.  Am J Vet Res.  2011 Oct;72(10):1369-77. PMID: 21962280

Wakshlag JJ, Schoeffler GL, Russell DS, Peters-Mo RM, Toulza O. Extravasation injury associated with parenteral nutrition in a cat with presumptive gastrinomas.  J Vet Emerg Crit Care, 2011 Aug;  21(4): 375-341 PMID: 21827596

Loftus JP, Morgan SK, Wakshlag JJ. Cloning and antibody recognition analysis of the canine 5-lipoxygenase gene. Vet Immunol Immunopath, 2011 Aug; 142(3-4): 276-279 PMID: 21616545

Heuberger R, Wakshlag J. The relationship of feeding patterns and obesity in dogs. J Anim Physiol Anim Nutr (Berl), 2010 Feb; 95(1): 98-105.  PMID: 20662965

Wakshlag JJ, Kraus MS, Gelzer AR, Downey RL, Vacchiani P.  The influence of high-intensity moderate duration exercise on cardiac troponin I and C-reactive protein in sled dogs.  J Vet Int Med, 2010 Nov-Dec; 24(6): 1388-1392. PMID: 20840303

Wakshlag JJ, Balkman CE.  The effects of lycopene on proliferation and death of canine osteosarcoma cells.  Am J Vet Res, 2010 Nov; 71(11): 1362-1370. PMID: 21034328

Cherrington BD, Morency E, Struble AM, Coonrod SA, Wakshlag JJ. Potential role for peptidylarginine deiminase 2 (PAD2) in citrullination of canine mammary epithelial cell histones. PLoS ONE, 2010 Jul 26; 5(7): e11768.  PMID: 20668670

Wakshlag JJ, Stokol T, Geske SM, Gregor CE, Angle CT, Gillette RL.  Evaluation of exercise-induced changes in concentrations of C-reactive protein and serum biochemical values in sled dogs completing a long-distance endurance race. Am J Vet Res, 2010 Oct; 71(10): 1207-1213. PMID: 20919909

Wakshlag JJ, de Lahunta A.  Hereditary encephalomyelopathy and polyneuropathy in an Alaskan Husky.  J Small Anim Pract. 2009 Dec; 50(12): 670-674.  PMID: 19954445

Malone EK, Rassnick KM, Wakshlag JJ, Russell DS, Al-Sarraf R, Ruslander DM, Johnson CS, Trump DL.  Calcitriol (1,25-dihydroxycholecalciferol) enhances mast cell tumour chemotherapy and  receptor tyrosine kinase inhibitor activity in vitro and has single-agent activity against spontaneously occurring canine mast cell tumours. Vet Comp Oncol. 2010 Sep; 8(3): 209-220.  PMID: 20691028

Wakshlag JJ, Balkman CA, Morgan SK, McEntee MC.  Evaluation of the protective effects of all-trans-astaxanthin on canine osteosarcoma cell lines.  Am J Vet Res. 2010 Jan; 71(1): 89-96.  PMID: 20043787

Angle CT, Wakshlag JJ, Gillette RL, Stokol T, Geske S, Adkins TO, Gregor C.  Hematologic, serum biochemical, and cortisol changes associated with anticipation of exercise and short duration high-intensity exercise in sled dogs.  Vet Clin Pathol. 2009 Sep; 38(3): 370-374.  PMID: 19351341

Intile JL, Rassnick KM, Bailey DB, Al-Sarraf R, Chretin JD, Balkman CE, Flory AB, Kiselow MA, Wakshlag JJ.  Evaluation of dexamethasone as a chemoprotectant for CCNU-induced bone marrow suppression in dogs. Vet Comp Oncol. 2009 Mar; 7(1): 69-77.  PMID: 19222832

Wakshlag JJ, Kallfelz FA, Wakshlag RR, Davenport GM. The effects of branched-chain amino acids in canine neoplastic cell proliferation and death. J  Nutr 2006 Jul; 136(7 Suppl): 2007S-2010S.  PMID: 16772481

Wakshlag JJ, McNeill CJ, Antonyak MA, Boehm JE, Fuji R, Balkman CE, Zgola M, Cerione RA, Page RL.  Expression and activity of transglutaminase II in spontaneous tumors of dogs and cats. J Comp Path. 2006 Feb-Apr; 134(2-3):202-210.  PMID: 16615935

Wakshlag JJ, Antonyak MA, Boehm JE, Boehm K, Cerione RA.  Effects of transglutaminase on beta-amyloid1-42-induced apoptosis.  Protein J. 2006 Jan; 25(1): 83-94. PMID: 16721663

Antonyak MA, Miller AM, Jansen JM, Boehm JE, Balkman CE, Wakshlag JJ, Page RL, Cerione RA.  Augmentation of tissue transglutaminase expression and activation by epidermal growth factor inhibit doxorubicin-induced apoptosis in human breast cancer cells.  J Biol Chem. 2004 Oct 1; 279 (40): 41461-41467.  PMID: 15272014

Wakshlag JJ, Snedden K, Reynolds AJ.   Biochemical and metabolic changes due to exercise in sprint-racing sled dogs: implications for post-exercise carbohydrate supplements and hydration management. Vet Ther. 2004 Spring; 5(1): 52-59. PMID: 15150730

Wakshlag JJ, Cooper BJ, Wakshlag RR, Kallfelz FA, Barr SC, Nydam DV, Dimauro S.  Biochemical evaluation of mitochondrial respiratory chain enzymes in canine skeletal muscle.  Am J Vet Res. 2004 Apr; 65(4): 480-484.  PMID: 15077691

Wakshlag JJ, Barr SC, Ordway GA, Kallfelz FA, Flaherty CE, Christensen BW, Shepard LA, Nydam DV, Davenport GM.  Effect of dietary protein on lean body wasting in dogs: correlation between loss of lean mass and markers of proteasome-dependent proteolysis.   J Anim Physiol Anim Nutr (Berl). 2003 Dec; 87(11-12): 408-420.  PMID: 14633050

Antonyak MA, McNeill CJ, Wakshlag JJ, Boehm JE, Cerione RA. Activation of the Ras-ERK pathway inhibits retinoic acid-induced stimulation of tissue transglutaminase expression in NIH3T3 cells. J Biol Chem. 2003 May 2; 278(18): 15859-15866.  PMID: 12604597

Wakshlag JJ, Snedden KA, Otis AM, Kennedy CA, Kennett TP, Scarlett JM, Kallfelz FA, Davenport GM, Reynolds AJ, Reinhart GA. Effects of post-exercise supplements on glycogen repletion in skeletal muscle. Vet Ther. 2002 Fall; 3(3): 226-234.  PMID: 12447829

Wakshlag JJ, Kallfelz FA, Barr SC, Ordway G, Haley NJ, Flaherty CE, Kelley RL, Altom EK, Lepine AJ, Davenport GM. Effects of exercise on canine skeletal muscle proteolysis: an investigation of the ubiquitin-proteasome pathway and other metabolic markers. Vet Ther. 2002 Fall; 3(3): 215-225.  PMID: 12447828

Tarrant J, Stokol T, Bartol J, Wakshlag J, Blue J. Diagnosis of malignant melanoma in a horse from cytology of body cavity fluid and blood. Equine Vet J. 2001 Sep; 33(5): 531-534.  PMID: 11558753

Brenner O, Wakshlag JJ, Summers BA, de Lahunta A. Alaskan Husky encephalopathy--a canine neurodegenerative disorder resembling subacute necrotizing encephalomyelopathy (Leigh syndrome). Acta Neuropathol. 2000 Jul; 100(1): 50-62.  PMID: 10912920

Wakshlag JJ, de Lahunta A, Robinson T, Cooper BJ, Brenner O, O'Toole TD, Olson J, Beckman KB, Glass E, Reynolds AJ.  Subacute necrotising encephalopathy in an Alaskan husky. J Small Anim Pract. 1999 Dec; 40(12): 585-589.  PMID: 10664957

Valentine BA, Reynolds AJ, Wakshlag J, Ducharme NG: Muscle glycogen, myopathy, and diet. World Equine Vet Rev 1997; 2: 27-31.