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William Hornbuckle

William E. Hornbuckle
Cornell University
College of Veterinary Medicine
Ithaca, NY 14853
weh4@cornell.edu

Selected Publications


Bowman DD, Hornbuckle WE, Vargas-Mendez L, STUDENTS, Armao C, Barry BM, Edmondson KM. Service Learning as Part of the Veterinary Curriculum: The Southside Community Center Well Pet Clinic. J Vet Ed (Submitted), 2004.

Tennant BC, Toshkov IA, Peek SF, Jacob JR, Menne S, Hornbuckle WE, Schinazi RD, Korba BE, Cote PJ, Gerin JL: Hepatocellular carcinoma in the woodchuck model of hepatitis I virus infection. Gastroenterology 127(5 Suppl 1):S283-293, 2004.

Peek SF, Cote PJ, Jacob JR, Toshkov IA, Hornbuckle WE, Baldwin BH, Wells FV, Chu CK, Gerin JL, Tennant, BC, Korba BE: Antiviral activity of Clevudine [L-FMAU, 1-(2-fluoro-5-methyl-? L-arabinofuranosyl) uracil] against WHV replication and gene expression in chronically infected woodchucks (M. Monax). Hepatology 33:254-266, 2001.

Cote PJ, Korba BE, Miller RH, Jacob JR, Baldwin BH, Hornbuckle WE, Purcell RH, Tennant BC, Gerin JL: Effects of age and viral determinants on chronicity as an outcome of experimental woodchuck hepatitis virus infection. Hepatology 31:190-200, 2000.

Hostetler KY, Beadle JR, Hornbuckle WE, Bellezza CA, Tochkov IA, Cote PJ, Gerin JL, Korba BE, Tennant BC: Antiviral activities of oral 1-0-hexadecylpropanediol-3-phosphoacyclovir and acyclovir in woodchucks with chronic woodchuck hepatitis virus infection. Antimicrob Agents Chemo 44:1964-1969, 2000.

Korba BE, Cote P, Hornbuckle WE, Schinazi R, Gangemi JD, Tennant BC and Gerin JL: Enhanced antiviral benefit of combination therapy with lamivudine and alpha interferon against WHV replication in chronic carrier woodchucks. Antiviral Therapy 5:95-104, 2000.

Korba BE, Cote P, Hornbuckle WE, Schinazi R, Gerin JL and Tennant BC: Enhanced antiviral benefit of combination therapy with lamivudine and famciclovir against WHV replication In chronic WHV carrier woodchucks. Antiviral Res 45:19-32, 2000.

Korba BE, Cote P, Hornbuckle WE, Tennant BC and Gerin JL: Treatment of chronic woodchuck hepatitis virus infection in the Eastern woodchuck (Marmota monax) with nucleoside analogues is predictive of therapy for chronic hepatitis B virus infection in humans. Hepatology 31:1165-1175, 2000.

Chen H-S, Miller RH, Hornbuckle WE, Tennant BC, Cote PJ, Gerin JL and Purcell RH: Titration of recombinant woodchuck hepatitis virus DNA in adult woodchucks. J MED VIROL 54: 92-94, 1998.

Tennant BC, Baldwin BH, Graham LA, Ascenzi MA, Hornbuckle WE, Rowland PH, Tochkov IA, Yeager AE, Erb HN, Colacino JM, Lopez C, Engelhardt JA, Bowsher RR, Richardson FC, Lewis W, Cote PJ, Korba BE and Gerin JL: Antiviral activity and toxicity of fialuridine in the woodchuck model of hepatitis B virus infection. HEPATOLOGY 28: 179-191, 1998.

Lewis W, Griniuviene B, Tankersley KO, Levine ES, Montione R, Engelman L, de Courten-Myers G, Ascenzi MA, Hornbuckle WE, Gerin JL and Tennant BC: Depletion of mitochondrial DNA, destruction of mitochondria, and accumulation of lipid droplets result from fialuridine treatment in woodchucks (Marmota monax). LAB INVEST 76: 77-87,1997.

Korba BA, Xie H, Wright KN, Hornbuckle WE, Gerin JL, Tennant BC and Hostetler KY: Liver-targeted antiviral nucleosides: Enhanced antiviral activity of phosphatidyl-dideoxyguanosine versus dideoxyguanosine in woodchuck hepatitis virus infection in vivo. HEPATOLOGY 23: 958-963, 1996.

Tennant BC, Baldwin BH, Hornbuckle WE, Korba BE, Cote PJ and Gerin JL: Animal models in the preclinical assessment of therapy for viral hepatitis. ANTIVIRAL THERAPY I (Suppl. 4): 47-52, 1996.

Mi L-J, Patil J, Hornbuckle WE, Cote PJ, Gerin JL, Tennant BC and Paronetto F: DNA ploidy analysis of hepatic preneoplastic and neoplastic lesions in woodchucks experimentally infected with woodchuck hepatitis virus. HEPATOLOGY 20: 21-29, 1994.

Chen H-S, Kaneko S, Girones R, Anderson RW, Hornbuckle WE, Tennant BC, Cote PJ, Gerin JL, Purcell RH and Miller RH: The woodchuck hepatitis virus X gene is important for establishment of virus infection in woodchucks. J VIROL 67: 1218-1226, 1993.

Foley GL, Anderson WI, Schlafer DH, Hornbuckle WE, Baldwin BH and Tennant BC: Neoplastic and nonneoplastic lesions of the reproductive tract of the woodchuck (Marmota monax). J ZOO WILDLIFE MED 24: 475-481, 1993.

Kew MC, Chestnut T, Baldwin BH, Hornbuckle WE, Tennant BC, Purcell RH and Miller RH: Heterogeneity of the woodchuck hepatitis virus genome in a chronically infected woodchuck. VIRUS RES 27: 229-237,1993.

Cote PJ, Korba BE, Baldwin B, Hornbuckle WE, Tennant BC and Gerin JL: Immunosuppression with cyclosporine during the incubation period of experimental woodchuck hepatitis virus infection increases the frequency of chronic infection in adult woodchucks. J INFECT DIS 166: 628-631, 1992.