photo of student with pony  

Advancing the health and well-being of animals and people


Ken Simpson

Kenneth W. Simpson
Cornell University
College of Veterinary Medicine
C2 011 VMC, Box 33
Ithaca, NY 14853
kws5@cornell.edu

Selected Publications


Batt R.M., Horadagoda N.U., McLean L., Morton D.B., Simpson K.W. (1989). Identification and characterization of a pancreatic intrinsic factor in the dog. American Journal of Physiology 256, G517-523.

Simpson K.W., Batt R.M., Morton D.B., Sorenson S.H., McLean L., Riley J. (1989). Biochemical changes in the jejunal mucosa of dogs with exocrine pancreatic insufficiency following pancreatic duct ligation. Research in Veterinary Science 47, 338-345.

Simpson K.W., Alpers D.H., DeWille J., Swanson P., Farmer S., Sherding R.G. (1993). Cellular localization and hormonal regulation of pancreatic intrinsic factor secretion in dogs. American Journal of Physiology 265, G178-188.

Pemberton, P.W., Lobley, R.L., Holmes, R., Sorenson, S.H., Simpson, K.W. and Batt, R.M. (1995). Characterization of microvillar membrane proteins of dog small intestine by two-dimensional electrophoresis. Comp. Biochem. Physiol. 110, 483-492.

Cornetta A., Simpson K.W., Strauss-Ayali D., McDonough P.L., Gleed R.D. (1998). Use of a 13C-urea breath test for detection of gastric infection with Helicobacter spp. in dogs. American Journal of Veterinary Research 59, 1364-1369.

Simpson K.W., Cobb M.A. (1998). Investigation of the relationship of circulating anti-pancreatic antibodies to exocrine pancreatic insufficiency in dogs. European Journal of Comparative Gastroenterology 3, 37-42.

Simpson K.W., McDonough P.L., Strauss-Ayali D., Chang Y-F., Harpending P., Valentine B.A. (1999). Helicobacter felis infection in dogs: effect on gastric structure and function. Veterinary Pathology 36, 237-248.

Strauss-Ayali D., Simpson K.W., Schein A.H., McDonough P.L., Jacobson R.H., Valentine B., Peacock J.(1999). Gastric Helicobacter spp.- Serological discrimination of infected and uninfected dogs. Journal of Clinical Microbiology 37, 1280-1287.

Simpson K.W., Strauss-Ayali D., McDonough P.L., Chang Y-F., Valentine B.A. (1999) Gastric function in dogs with naturally acquired Helicobacter spp infection. Journal of Veterinary Internal Medicine 13, 507-515. (Editorial p. 505-506)

Simpson K.W., Strauss-Ayali D., Scanziani E., Straubinger R.K., McDonough P.L., Straubinger A.F., Chang Y-F., Domenghini C., Arebi N., Calam J. (2000) Helicobacter felis infection is associated with lymphoid follicular hyperplasia and mild gastritis but normal gastric secretory function in cats. Infection and Immunity 68, 779-790.

Scanziani E., Simpson K.W., Monestiroli S., Soldati S., Strauss-Ayali D., Del Piero F. (2001) Histological and immunohistochemical identification of different Helicobacter species in the gastric mucosa of cats. Journal of Veterinary Diagnostic Investigation 13, 3-12.

Simpson K.W., Fyfe J., Cornetta A., Sachs A., Strauss-Ayali D., Lamb S., Reimers T. (2001). Subnormal concentrations of serum cobalamin (vitamin B12) in cats with gastrointestinal disease. Journal of Veterinary Internal Medicine 15, 26-32.

Simpson K.W., Strauss-Ayali D., Straubinger R.K., Scanziani E., McDonough P.L., Straubinger A.F., Esteves M., Fox J.G., Chang Y-F., Domenghini C., Arebi N., Calam J. (2001) Helicobacter pylori infection in the cat: evaluation of gastric colonization, inflammation and function. Helicobacter 6, 1-14.

Strauss-Ayali D., Scanziani E., Deng D., Simpson K.W. (2001) Helicobacter spp. infection in cats: Evaluation of the humoral immune response and prevalence of gastric Helicobacter spp. Veterinary Microbiology 79, 253-265.

Raghavan PUM, McDonough SP, Barr SC, Divers TJ, McDonough PL, Simpson KW, Chang YF. (2002) Cloning and molecular characterization of an immunogenic LigA protein of Leptospira interrogans. Infection and Immunity 70, 5924-5930.

Straubinger RK, Greiter A, McDonough SP, Gerold A, Scanziani E, Soldati S, Dailidiene D, Dailide G, Berg DE and Simpson KW. (2003) Quantitative evaluation of inflammatory and immune responses in the early stages of Helicobacter pylori infection. Infection and Immunity 71:2693-2703.

Priestnall SL, Wiinberg B, Spohr A, Neuhaus B, Kuffer M, Wiedmann M, Simpson KW. Evaluation of ""Helicobacter heilmannii"" subtypes in the gastric mucosas of cats and dogs. J Clin Microbiol. 2004, 42:2144-51.

Wiinberg, B, Spohr, A, Dietz, HH, Egelund, T, Greiter-Wilke, A, McDonough, SP, Olsen, J, Priestnall, S, Chang, YF and Simpson, K.W. (2005) Quantitative analysis of inflammatory and immune responses in dogs with gastritis and their relationship to Helicobacter spp. Infection. Journal of Veterinary Internal Medicine19:4-14.

Garden, OA, Reubi, JC, Dykes, NL, Yeager, AE, McDonough, SP and Simpson, K.W. (2005) Somatostatin receptor imaging in vivo by planar scintigraphy facilitates the diagnosis of canine insulinomas. Journal of Veterinary Internal Medicine 19, 168-76.

K. W. Simpson, B. Dogan, M. Rishniw, R. E. Goldstein, S. Klaessig, P. L. McDonough, A. J. German, R. M. Yates, D.G. Russell, S. E. Johnson, D. E. Berg, J. Harel, G. Bruant, S. P. McDonough, Y. H. Schukken. (2006). Adherent and Invasive Escherichia coli are Associated with Ulcerative Colitis of Boxer Dogs. Infection and Immunity 74,4778-4792.

B. Dogan, S. Klaessig, M. Rishniw, R. A. Almeida, S. P. Oliver, K.W. Simpson and Y. H. Schukken. (2006) Adherent and Invasive Escherichia coli are associated with persistent bovine mastitis. Veterinary Microbiology 116(4):270-82.

A.Greiter-Wilke, E.Scanziani, S.Soldati, S.P. McDonough, P.L.McDonough, S.A.Center M.Rishniw and K.W.Simpson. (2006). Evaluation of the association of Helicobacter with feline cholangiohepatitis. Journal of Veterinary Internal Medicine 20, 822-828.

Recordati C., Gualdi V., Vailati Facchini R., Pengo G., Luini M., Simpson K.W., Scanziani E. (2007) Detection of Helicobacter spp. DNA in the oral cavity of dogs. Veterinary Microbiology 119,346-51.

Baumgart, M, Dogan, B, Rishniw, M, Weitzman, G, Bosworth, B, Yantiss, R, Orsi, R, Wiedmann, M, McDonough, P, Kim SG, Berg, D, Schukken, Y, Scherl, E, and Simpson, K.W. (2007) Culture independent analysis of ileal mucosa reveals a selective increase in invasive Escherichia coli of novel phylogeny relative to depletion of Clostridiales in Crohn's ileitis. ISME J,1(5):403-18.

Janeczko S, Goldstein R, Greiter-Wilke A, Gerold A, Baumgart M, Atwater D, Bender H, McDonough PL, McDonough SP, Simpson KW. (2008). The relationship of mucosal bacteria to duodenal histopathology, cytokine mRNA, and clinical disease activity in cats with inflammatory bowel disease Vet Microbiol, 128:178-93.

Kiselow MA, Rassnick KM, McDonough SP, Goldstein RE, Simpson KW, Weinkle TK, Erb HN. (2008) Outcome of cats with low-grade lymphocytic lymphoma: 41 cases (1995-2005).J Am Vet Med Assoc. 1;232 (3):405-10.

Vyhnal KK, Barr SC, Hornbuckle WE, Yeager AE, Wade SE, Frongillo MF, Simpson KW, Bowman DD. (2008). Eurytrema procyonis and pancreatitis in a cat. J Feline Med Surg.Feb 27

Dogan, BE, Simpson KW. (2008). Microflora in Crohn's disease: the emergence of adherent and invasive Escherichia coli. Expert Review of Clinical Immunology, 4, 133-137.

Simpson KW. (2008). Ulcerative Colitis in Boxers. Standards of Care, Vol 10, No 3. Recordati C, Radaelli E, Simpson KW, Scanziani E.A simple method for the production of bacterial controls for immunohistochemistry and fluorescent in situ hybridization.J Mol Histol. 2008 May 31.

Porciello F, Rishniw M, Herndon WE, Birettoni F, Antognoni M and Simpson KW. Cardiac Troponin I is elevated in dogs and cats with azotemic renal failure and in dogs with non-cardiac systemic disease. Aus Vet J. In Press

Shanies TA, Goldstein RE, Njaa BL, Atwater DZ., Chang YF and Simpson KW. Search for Borrelia burgdorferi in Kidneys of Dogs with Suspected "Lyme Nephritis."JVIM. In press

Sekis I, Ramstead K, Rishniw M, Schwark WS, McDonough SP, Goldstein RE, Papich M and Simpson KW. Single-dose Pharmacokinetics and Genotoxicity of Metronidazole in Cats. J Feline Med Surg In Press

Jergens AE, Pressel M, Crandell J, Morrison J, Sorden, SD, Haynes J, Baumgart M, and Simpson KW. Fluorescence in situ hybridization confirms eradication of naturally-acquired helicobacter gastritis in the dog and cat. JVIM submitted