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Mammary stem cells

Our laboratory is focused on the isolation and characterization of stem cells from the mammary gland (MaSC) of different animal species. We are interested in these cells because stem cells are believed to govern development of many different cancers, including breast cancer. Therefore, studies on how MaSC regulate their stem cell properties will lead to tools for effective identification of cancer cells and will provide new strategies to target them for destruction.

Selected publications:

1) Mammary stem cell research in veterinary science: an update.
Borena BM, Bussche L, Burvenich C, Duchateau L, Van de Walle GR.
Stem Cells Dev. 2013 Jun 15;22(12):1743-51.

2) Stem/progenitor cells in non-lactating versus lactating equine mammary gland.
Spaas JH, Chiers K, Bussche L, Burvenich C, Van de Walle GR.
Stem Cells Dev. 2012 Nov 1;21(16):3055-67.

3) Microvesicle-mediated Wnt/β-Catenin Signaling Promotes Interspecies Mammary Stem/Progenitor Cell Growth.
Bussche L, Rauner G, Antonyak M, Syracuse B, McDowell M, Brown AM, Cerione RA, Van de Walle GR.
J Biol Chem. 2016 Nov 18;291(47):24390-24405.
PMID: 27733685 [PubMed - in process]

4) A Comparative Study on the In Vitro Effects of the DNA Methyltransferase Inhibitor 5-Azacytidine (5-AzaC) in Breast/Mammary Cancer of Different Mammalian Species.
Harman RM, Curtis TM, Argyle DJ, Coonrod SA, Van de Walle GR.
J Mammary Gland Biol Neoplasia. 2016 Jun;21(1-2):51-66. doi: 10.1007/s10911-016-9350-y.
PMID: 27002722 [PubMed - in process]