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Mesenchymal stem cells

We are studying the basic fundaments of equine mesenchymal stem cells (MSC) in order to better understand their "mode of action" in regenerative medicine. Investing in more in-depth research to better characterize these cells and to fully understand the potential of MSC-based therapies, will allow us in the long run to design safe and efficient therapeutic protocols. In addition, because the horse is such a good model for a variety of human diseases, our research is not only important for equine medicine but will also be of value for human medicine.

Selected publications:

1) Microencapsulated equine mesenchymal stromal cells promote cutaneous wound healing in vitro.
Bussche L, Harman RM, Syracuse BA, Plante EL, Lu YC, Curtis TM, Ma M, Van de Walle GR.
Stem Cell Res Ther. 2015 Apr 11;6(1):66. [Epub ahead of print]

2) Peripheral Blood-Derived Mesenchymal Stromal Cells Promote Angiogenesis via Paracrine Stimulation of Vascular Endothelial Growth Factor Secretion in the Equine Model
Bussche L, Van de Walle GR.
Stem Cells Transl Med. 2014 Dec;3(12):1514-25. doi: 10.5966/sctm.2014-0138. Epub 2014 Oct 13.

3) Characterization and profiling of immunomodulatory genes of equine mesenchymal stromal cells from non-invasive sources.
De Schauwer C, Goossens K, Piepers S, Hoogewijs MK, Govaere JL, Smits K, Meyer E, Van Soom A, Van de Walle GR.
Stem Cell Res Ther. 2014 Jan 13;5(1):6. doi: 10.1186/scrt395.

4) Equine Mesenchymal Stromal Cells from Different Sources Efficiently Differentiate into Hepatocyte-Like Cells.
Pennington MR, Curtis TM, Divers TJ, Wagner B, Ness SL, Tennant BC, Van de Walle GR.
Tissue Eng Part C Methods. 2016 Jun;22(6):596-607. doi: 10.1089/ten.TEC.2015.0403.
PMID: 27113698 [PubMed - in process]