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Viral Pathogenesis

We are studying the viral pathogenesis of alphaherpesviruses, a subfamily of the Herpesviridae. These viruses can cause severe illness in a wide variety of avian and mammalian species, including humans, and are known to establish latent infection in their host. Our overall goal is to develop virus-natural host models, in vitro as well as in vivo, to gain more insights into the underlying mechanisms of herpesvirus infections and reactivation.

Selected publications:

1) Equid herpesvirus 1 (EHV1) infection of equine mesenchymal stem cells induces a pUL56-dependent downregulation of select cell surface markers.
Claessen C, Favoreel H, Ma G, Osterrieder N, De Schauwer C, Piepers S, Van de Walle GR
Vet Microbiol. 2015 Mar 23;176(1-2):32-9. doi: 10.1016/j.vetmic.2014.12.013. Epub 2014 Dec 23.

2) Establishment and characterization of an air-liquid canine corneal organ culture model to study acute herpes keratitis.
Harman RM, Bussche L, Ledbetter EC, Van de Walle GR.
J Virol. 2014 Dec;88(23):13669-77. doi: 10.1128/JVI.02135-14. Epub 2014 Sep 17.

3) Histone modifications in herpesvirus infections.
Van Opdenbosch N, Favoreel H, Van de Walle GR.
Biol Cell. 2012 Mar;104(3):139-64.

4) A novel corneal explant model system to evaluate antiviral drugs against feline herpesvirus type 1 (FHV-1).
Pennington MR, Fort MW, Ledbetter EC, Van de Walle GR.
J Gen Virol. 2016 Jun;97(6):1414-25. doi: 10.1099/jgv.0.000451.
PMID: 26959283 [PubMed - in process]

5) Characterization of nonprimate hepacivirus and construction of a functional molecular clone.
Scheel TK, Kapoor A, Nishiuchi E, Brock KV, Yu Y, Andrus L, Gu M, Renshaw RW, Dubovi EJ, McDonough SP, Van de Walle GR, Lipkin WI, Divers TJ, Tennant BC, Rice CM.
Proc Natl Acad Sci U S A. 2015 Feb 17;112(7):2192-7. doi: 10.1073/pnas.1500265112.
PMID: 25646476 [PubMed - indexed for MEDLINE]