Introducing the Center for Reproductive Genomics:

Cornell University has established the Center for Reproductive Genomics, which will combine basic and clinical research in reproductive sciences on Cornell's Ithaca campus and at Weill Cornell Medical College (WCMC) in New York City, which has one of the country's leading fertility clinics. Infertility affects 10 to 15 percent of couples of childbearing age. The Center for Reproductive Genomics is on the web at http://reprogenomics.cornell.edu.

Our latest publications:

Paduch DA, Bolyakov A, Cohen P, Travis A. Reproduction in men with Klinefelter syndrome: the past, the present, and the future. Semininars in Reproductive Medicine. 27(2):137-48. (2009)

Roa S, Avdievich E, Peled JU, Maccarthy T, Werling U, Kuang FL, Kan R, Zhao C, Bergman A, Cohen PE, Edelmann W, Scharff MD. Ubiquitylated PCNA plays a role in somatic hypermutation and class-switch recombination and is required for meiotic progression. Proc Natl Acad Sci U S A. 105(42):16248-53 (2008)

Holloway JK, Booth J, Edelmann W, McGowan CH, Cohen PE. MUS81 Generates a Subset of MLH1-MLH3-Independent Crossovers in Mammalian Meiosis. PLoS Genetics 4(9):e1000186. (2008)

Morelli MA, Werling U, Edelmann W, Roberson MS, Cohen PE. Analysis of meiotic prophase I in live mouse spermatocytes. Chromosome Research 16(5):743-60 (2008)

Kan R., Sun X., Kolas N.K., Avdievich E., Kneitz B., Edelmann W., & Cohen P.E. Comparative Analysis of Meiotic Progression in Female Mice Bearing Mutations in Genes of the DNA Mismatch Repair Pathway. Biology of Reproduction. 78: 462–471 (2008)

Avdievich E., Reiss C., Scherer S.S., Jin B., Cohen P.E., Edelmann W. & Kneitz B. Distinct effects of an MLH1 ATPase mutation on MMR functions, cancer and meiosis. Proceedings of the National Academy of Sciences U.S.A. 105: 4247-4252 (2008)

Svetlanov A., Baudat F., Cohen P.E., and De Massy B. Distinct functions of MLH3 at recombination hot spots in the mouse. Genetics. 178: 1937- 1945 (2008).