Publications

  1. Qiao H, Prasada Rao HB, Yang Y, Fong JH, Cloutier JM, Deacon DC, Nagel KE, Swartz RK, Strong E, Holloway JK, Cohen PE, Schimenti J, Ward J, Hunter N.  Antagonistic roles of ubiquitin ligase HEI10 and SUMO ligase RNF212 regulate meiotic recombination. Nature Genetics Jan 5. doi: 10.1038/ng.2858. [Epub ahead of print] DOWNLOAD PMID: 24390283
  2. Auton A, Rui Li Y, Kidd J, Oliveira K, Nadel J, Holloway JK, Hayward JJ, Cohen PE, Greally JM, Wang J, Bustamante CD, Boyko AR. Genetic Recombination Is Targeted towards Gene Promoter Regions in Dogs.  PLoS Genetics; 9(12):e1003984 (2013) DOWNLOAD PMID: 24348265
  3. Pinto RM, Dragileva E, Kirby A, Lloret A, Lopez E, St Claire J, Panigrahi GB, Hou C, Holloway K, Gillis T, Guide JR, Cohen PE, Li GM, Pearson CE, Daly MJ, Wheeler VC.  Mismatch repair genes Mlh1 and Mlh3 modify CAG instability in Huntington's disease mice: genome-wide and candidate approaches. PLoS Genetics;  9(10):e1003930. (2013) DOWNLOAD
  4. Zhang J., Bonasio R., Strino F., Kluger Y., Holloway J.K., Modzelewski A.J., Cohen P.E., and Reinberg D. SFMBT1 Functions with LSD1 to regulate expression of canonical histone genes and chromatin-related factors. Genes & Development 27(7);749-766 (2013) DOWNLOAD PMID: 23592795
  5. Reynolds A., Qiao H., Yank Y., Chen J.K., Jackson N., Biswas K., Holloway J.K., Baudat F., DeMassy B., Wang J., Hoog C., Cohen P.E., & Hunter N. . RNF212 is a haploinsufficient regulator of crossing-over during mammalian meiosis. Nature Genetics. 45(3): 269-278 (2013) DOWNLOAD PMID: 23396135
  6. Lyndaker A.M, Lim P.X., Mleczko J.M., Diggins C.E., Holloway J.K., Holmes R.J., Kan R., Schlafer D.H., Freire R., Cohen P.E., & Weiss R.S. Conditional inactivation of the DNA damage response gene Hus1 in mouse testis reveals separable roles for components of the RAD9-RAD1-HUS1 complex in meiotic chromosome maintenance PLoS Genetics. Feb;9(2):e1003320 (2013) DOWNLOAD PMID: 23468651
  7. Sun X, Wu X., & Cohen P.E. Non-human primates exhibit errors in meiosis I. Molecular Reproduction and Development 79: 665 (2012). PMID: 22968934 DOWNLOAD
  8. Sun X. & Cohen P.E. Studying recombination in mouse oocytes. Methods in Molecular Biology 957: 1-18 (2012). PMID: 23138941
  9. Modzelewski A.J., Holmes R.J., Hilz S., Grimson A., Cohen P.E. AGO4 regulates entry into meiosis and influences silencing of sex chromosomes in the male mouse germline. Developmental Cell. 23: 251-264 (2012) DOWNLOAD
  10. Holloway J.K., Mohan S., Balmus G., Sun X., Modzelewski A., Borst P.L., Freire R. Weiss R.S., Cohen P.E. Mammalian BTBD12 (SLX4) protects against genomic instability during mammalian spermatogenesis. PLoS Genetics 7(6): e1002094 (2011) DOWNLOAD
  11. Holloway J.K., Roberson E.K., Corbett K., Kolas N.K., Cohen P.E. NEK1 facilitates cohesin removal during mammalian spermatogenesis. Genes 2(1): 260-279 (2011) DOWNLOAD
  12. Cohen P.E., Holloway J.K. Computational approaches to modeling gene networks in human meiosis. Biology of Reproduction 82: 469-472 (2010) PMID: 20032284 DOWNLOAD
  13. Holloway J.K., Morelli M.A., Cohen P.E. The Mouse Ortholog of the Human Bloom's Syndrome Mutated (BLM) is Critical for Integrating Multiple Pathways of Recombination during Meiosis. Journal of Cell Biology 188: 779-789 (2010). PMID: 20308424 DOWNLOAD
  14. Paduch D.A., Bolyakov A., Cohen P.E., Travis A.J. Reproduction in men with Klinefelter syndrome: the past, the present, and the future. Seminars in Reproductive Medicine. 27(2):137-48 (2009).
  15. Kan R., Sun X., Kolas N.K., Wei K., Edelmann W, and Cohen P.E. Disruption of meiotic metaphase I in female mice carrying mutations in various components of the mismatch repair pathway. Biology of Reproduction. 78:462-471 (2008). PMID: 18057311 DOWNLOAD
  16. Avdievich E., Reiss C., Scherer S.S., Jin B., Cohen P.E., Edelmann W. and Kneitz B. Distinct effects of an MLH1 ATPase mutation on MMR functions, cancer and meiosis. Proceedings of the National Academy of Sciences U.S.A. 105(11):4247-52. (2008). PMID: 18337503 DOWNLOAD
  17. Svetlanov A., Baudat F., Cohen P.E., and DeMassy B. Distinct functions of MLH3 at recombination hot spots in the mouse. Genetics  178: 1937–1945 (2008). PMID: 18430927 DOWNLOAD
  18. Morelli M., Werling U., Edelmann W., Roberson M.S., Cohen P.E. Analysis of Meiotic Prophase I in Live Mouse Spermatocytes. Chromosome Research 16: 743-760 (2008). PMID: 18516692 DOWNLOAD
  19. Holloway J.K., Booth J., Edelmann W., McGowan C.H., Cohen P.E. MUS81 generates a subset of MLH1-MLH3 independent crossovers in mammalian meiosis. PLoS Genetics 4(9):e1000186 (2008). PMID: 18787696 DOWNLOAD
  20. Roa S. , Avdievich E., Peled J., MacCarthy T., Werling U., Kuang F.L., Kan R., Zhao C., Bergman A., Cohen P.E., Edelmann W., Scharff M.D. Ubiquitylated PCNA plays a role in somatic hypermutation and class-switch recombination and is required for meiotic progression. Proceedings of the National Academy of Sciences U.S.A. 105(42):16248-53 (2008). PMID: 18854411 DOWNLOAD
  21. Holmes, R.J. and Cohen, P.E. Small RNAs and the RNAi pathway in meiotic prophase I. Chromosome Research 15:653-665 (2007). PMID: 17674152 DOWNLOAD
  22. Li Z., Peled J.U., Zhao C., Svetlanov A., Ronai D., Cohen P.E., and Scharff M.D. A role for MLH3 in somatic hypermutation. DNA Repair 5: 675-682 (2006). PMID: 16564751 DOWNLOAD
  23. Cohen P.E., Pollack S.E. and Pollard J.W. Genetic analysis of chromosome pairing, recombination and cell cycle control during the first meiotic prophase in mammals. Endocrine Reviews 27: 398-426 (2006). PMID: 16543383 DOWNLOAD
  24. Lenzi, M., Smith, J., Snowden, T., Kim, M., Fishel, R., Poulos, B., and Cohen, P.E. Extreme heterozygosity in the molecular events leading to the establishment of chiasmata during meiosis I in human oocytes. American Journal of Human Genetics 76 (1): 11-127 (2005). PMID: 15558497 DOWNLOAD
  25. Li, B., Nair, M., Mackay, D.R., Bilanchone, V., Hu, M., Fallahi, M., Song, H., Dai, Q., Cohen, P.E. and Dai, X. Ovol1 regulates meiotic pachytene progression during spermatogenesis by repressing Id2 expression. Development 132(6): 1463-1473 (2005). PMID: 15716349
  26. §Kolas, N.K., §Svetlanov, A., Lenzi, M., Smith, J., Macaluso, F.P., Greally, J.M., Edelmann, W., Liskay, R.M., Lipkin, S.M., and Cohen, P.E. Distinct functions of MutL homologs in reciprocal recombination and gene conversion in mammalian meiosis. §These authors contributed equally to this work. Journal of Cell Biology 171(3): 447-458 (2005). PMID: 16260499 DOWNLOAD
  27. Morelli, M.A. and Cohen, P.E.  Not all germ cells are created equal: aspects of sexual dimorphism in mammalian meiosis. Reproduction 130: 761-781 (2005). PMID: 16322537 DOWNLOAD
  28. Svetlanov, A., and Cohen, P.E. Mismatch repair proteins, meiosis, and mice: understanding the complexities of mammalian meiosis. Experimental Cell Research 296(1): 71-79 (2004) DOWNLOAD
  29. Kolas, N.K., and Cohen, P.E. Novel and diverse function of the DNA mismatch repair family in mammalian meiosis and recombination. Cytogenetic and Genome Research 107: 216-231 (2004). DOWNLOAD
  30. Wei K., Clark A.B., Wong E., Kane M.F., Mazur D.J., Parris T., Kolas N.K., Russell R., Kneitz B., Kunkel T.A., Kolodner R.D., Cohen P.E. & Edelmann W. Inactivation of exonuclease I in mice results in DNA mismatch repair defects, increased cancer susceptibility and male and female sterility. Genes and Development 17(5): 603-614 (2003).
  31. §Crackower, M., §Kolas, N., Noguchi, J., Sarao, R., Kikuchi, K., Kaneko, H., Kobayashi, E., Kawai, Y., Kozieradzki, I., Landers, R., Mo, R., Hui, C., Nieves, E., Cohen, P.E., Osborne, L., Wada, T., Kunieda, T., Moens, P.B., and Penninger, J.M. Essential Role of Fkbp6 in Male Fertility and Homologous Chromosome Pairing in Meiosis. § These authors contributed equally to this work. Science 300:1291-1295 (2003).
  32. Moens P.B., Kolas N.K., Tarsounas M., Marcon E., Cohen P.E. and Spyropoulos B. The time course and localization of recombination-related proteins at meiosis in the mouse conform to models that can resolve the early DNA-DNA interactions without reciprocal recombination. Journal of Cell Science 115: 1611-1622 (2002). DOWNLOAD
  33. Lipkin S.M., Moens P.B., Wang V., Lenzi M., Shanmugarajah D., Gilgeous A., Thomas J., Cheng J., Touchman J.W., Green E.D., Schwartzberg P., Collins F.S. & Cohen P.E. Meiotic arrest and aneuploidy in Mlh3-defcient mice. Nature Genetics 31(4): 385-390 (2002). DOWNLOAD
  34. Cohen P.E., Zhu, L., Nishimura, K. & Pollard, J.W. Colony stimulating factor-1 (CSF-1) regulation of neuroendocrine pathways that control gonadal function. Endocrinology 143: 1413-1422 (2002).
  35. Cohen, P.E. & Pollard, J.W. Regulation of meiotic recombination and prophase I progression in mammals. BioEssays, 23: 996-1009 (2001). DOWNLOAD
  36. §Kneitz B., §Cohen P.E., Avdievich E., Zhu L., Kane M.F., Hou H., Kolodner R.D., Pollard J.W., Kucherlapati R. & Edelmann W. MutS homolog 4 (MSH4) localization to meiotic chromosomes is required for chromosome pairing during meiosis in male and female mice. § These authors contributed equally to this work. Genes and Development. 14: 1085-1097 (2000). DOWNLOAD
  37. Zindy, F., Den Besten, W., Chen, B., Latres, E., Barbacid, M., Sherr, C.J., Pollard, J.W., Cohen P.E., & Roussel, M.F. The cyclin-dependent kinase inhibitors, INK4c and INK4d, control spermatogenesis in mice. Molecular and Cellular Biology 21: 3244-3255 (2000).
  38. §Edelmann W., §Cohen P.E., Kneitz B., Winand N., Heyer J., Kolodner R., Pollard J.W. & Kucherlapati R. Mammalian MutS homolog 5 is required for chromosome pairing in meiosis. § These authors contributed equally to this work. Nature Genetics 21: 123-127 (1999). DOWNLOAD
  39. Cohen P.E., Nishimura K., Zhu L. & Pollard J.W. Macrophages: Important accessory cells for reproduction. Journal of Leukocyte Biology 66: 765-772 (1999).
  40. Cohen P.E. & Pollard J.W. Normal sexual function in male mice lacking a functional type I interleukin-1 receptor. Endocrinology 139: 815-818 (1998).
  41. Edelmann W., Yang K., Umar A., Heyer J., Lau K., Fan K., Liedtke W., Cohen P.E., Kane M.F., Lipford J.R., Yu N., Crouse G., Pollard J.W., Kunkel T., Lipkin M., Kolodner R. & Kucherlapati R. Mutation in the mismatch repairgene MSH6 causes cancer susceptibility. Cell 91: 467-477 (1997). DOWNLOAD
  42. Cohen P.E., Zhu L. & Pollard J.W. Absence of colony stimulating factor-1 in osteopetrotic (csfmop/csfmop) mice disrupts estrous cycles and ovulation. Biology of Reproduction 56: 110-119 (1997).
  43. Pollard J.W., Dominguez M.G., Mocci S., Cohen P.E. & Stanley E.R. Effect of the colony stimulating factor-1 (CSF-1) null mutation, osteopetrotic (csfmop), on the distribution of macrophages in the male reproductive tract. Biology of Reproduction 56: 1290-1300 (1997).
  44. Cohen P.E., Hardy M.P. & Pollard J.W. CSF-1 plays a major role in the development of reproductive function in male mice. Molecular Endocrinology 11: 1636-1650 (1997).
  45. Cohen P.E., Chisholm O., Arceci R.J., Stanley E.R. & Pollard J.W. Absence of colony stimulating factor-1 in osteopetrotic (csfmop/csfmop) mice results in male fertility defects. Biology of Reproduction 55: 310-317 (1996).
  46. Cohen P.E. & Pollard J.W. Cytokines and growth factors in reproduction. In: Reproductive Immunology (Bronson R.A., Alexander N.J., Anderson D., Branch D.W., & Kutteh W.H., editors). Blackwell Science, Cambridge, MA. Chapter 3, pages 52-102 (1996).
  47. Edelmann W., Cohen P.E., Kane M., Lau K., Morrow B., Bennett S., Umar A., Kunkel T., Cattoretti G., Chaganti R., Pollard J.W., Kolodner R.D. & Kucherlapati R. Meiotic pachytene arrest in MLH-1-deficient mice. Cell 85: 1125-1134 (1996). DOWNLOAD
  48. Milligan S.R., Cohen P.E. & Finn C.A. The minimum requirements for oestradiol to induce uterine sensitivity for implantation and decidualization in mice. Human Reproduction 10: 1502-1506 (1995).
  49. Cohen P.E. & Pollard J.W. Use of the osteopetrotic mouse for studying macrophages in the reproductive tract. In: Immunobiology of Reproduction (J.S. Hunt, editor). Springer-Verlag, New York. Chapter 8, pages 104-122 (1994).
  50. Cohen P.E. & Milligan S.R. Silastic implants for delivery of oestradiol to mice. Journal of Reproduction and Fertility 99: 219-223 (1993).