research areas

There are four broad areas of research in the Cohen lab, all centered on understanding how mammalian germ cells are made and what errors might occur and be responsible for the high rates of chromosomal abnormalities in human embryos. Our studies utilize mostly mouse models for meiosis, but we have extended these studies more recently to humans (see Lenzi et al, 2005), dogs, and monkeys.

The major research areas are:

1. Studies of meiotic recombination and crossover control in the mouse

2. Understanding the role of small RNAs and Argonaute proteins in meiosis

3. Exploring the role of the Fanconi Anemia pathway in mammalian germ cell development and meiosis

4. Understanding the role of the MAP kinase cascade in meiotic checkpoint control

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

recent publications ....

 

Zhang J., Bonasio R., Strino F., Kluger Y., Holloway J.K., Modzelewski A.J., Cohen P.E., and Reinberg D. SFMBT1 Functions with LSD1 to regulate expression of canonical histone genes and chromatin-related factors. Genes & Development 27(7);749-766 (2013)

Reynolds A., Qiao H., Yank Y., Chen J.K., Jackson N., Biswas K., Holloway J.K., Baudat F., DeMassy B., Wang J., Hoog C., Cohen P.E., & Hunter N. . RNF212 is a haploinsufficient regulator of crossing-over during mammalian meiosis. Nature Genetics. 45(3): 269-278 (2013)

Lyndaker A.M, Lim P.X., Mleczko J.M., Diggins C.E., Holloway J.K., Holmes R.J., Kan R., Schlafer D.H., Freire R., Cohen P.E., & Weiss R.S. Conditional inactivation of the DNA damage response gene Hus1 in mouse testis reveals separable roles for components of the RAD9-RAD1-HUS1 complex in meiotic chromosome maintenance PLoS Genetics. Feb;9(2):e1003320 (2013)

Sun X, Wu X., & Cohen P.E. Non-human primates exhibit errors in meiosis I. Molecular Reproduction and Development 79: 665 (2012).

Sun X. & Cohen P.E. Studying recombination in mouse oocytes. Methods in Molecular Biology 957: 1-18 (2012).