JOURNAL COVERS

 

     

Gonzalez, A,D, Wang, G, Waters, E,M, Gonzales, K,L, Speth, R,C, Van Kempen, T,A, Marques-Lopes, J, Young, C,N, Butler, S,D, Davisson, R,L, Iadecola, C, Pickel, V,M, Pierce, J,P, Milner, T.A. Distribution of angiotensin type 1a receptor containing cells in the brains of bacterial artificial chromosome transgenic mice. J Neurosci 2012 Dec;226:489-509. PDF

Young, CN, Cao, X, Guruju, MR, Pierce, JP, Morgan, DA, Wang, G, Iadecola, C, Mark, AL, Davisson, RL. ER stress in the brain subfornical organ mediates angiotensin-dependent hypertension. J Clin Invest 2012 Nov;122:3960-3964. PDF   (Editorial commentary: J Clin Invest 2012 Nov;122:3859-3861.)

Hicks, M, Rosenberg, JB, De, BP, Pagovich, O, Young, CN, Qiu, JP, Kaminsky, SM, Hackett, NR, Worgall, S, Janda, K, Davisson, RL, Crystal, RG. AAV-directed persistent expression of a gene encoding anti-nicotine antibody for smoking cessation. Sci Transl Med 2012 Jun;4:140ra87. (featured in Research Highlights, Nature 487:8, 2012) PDF

Capone, C, Faraco, G, Coleman, C, Young, CN, Pickel, VM, Anrather, J, Davisson, RL, Iadecola, C. Endothelin 1-dependent neurovascular dysfunction in chronic intermittent hypoxia. Hypertension 2012 Jun;60:106-113. PDF

Capone, C, Faraco, G, Peterson, J, Coleman, C, Anrather, J, Milner, TA, Pickel, V, Davisson, RL, Iadecola, C. Central cardiovascular circuits contribute to the neurovascular dysfunction in angiotensin-II hypertension. J Neurosci 2012 Apr;32:4878-4886. PDF

Cao, X, Peterson, JR, Wang, G, Anrather, J, Young, CN, Guruju, MR, Burmeister, MA, Iadecola, C, Davisson, RL. Angiotensin-II-dependent hypertension requires cyclooxygenase 1-derived prostaglandin E2 and EP1 receptor signaling in the subfornical organ of the brain. Hypertension 2012 Mar;59:869-876. PDF

Young C, Davisson RL. In vivo assessment of central neurocardiovascular regulation in the mouse: principles, progress and prospects. Am J Physiol Heart Circ Physiol 2011 Sept;301:H654-H662. PDF

Rahmouni K, Davisson RL, Sigmund CD. Inflaming hypothalamic neurons raises blood pressure. Cell Metabolism 2011 Jul;14:3-4. PDF

Spencer NY, Yan Z, Boudreau RL, Zhang Y, Luo M, Li Q, Tian X, Shah AM, Davisson RL, Davidson B, Banfi B, Engelhardt JF. Control of hepatic nuclear superoxide production by glucose 6-phosphate dehydrogenase and nadph oxidase-4. J Biol Chem 2011 Mar;286:8977-8987. PDF

Burmeister MA, Young CN, Braga VA, Butler SD, Sharma RV, Davisson RL. In vivo bioluminescence imaging reveals redox-regulated activator protein-1 activation in paraventricular nucleus of mice with renovascular hypertension. Hypertension 2011 Feb;57(2):289-297. PDF

Qing X, Redecha PB, Burmeister MA, Tomlinson S, D'Agati, VD, Davisson RL, Salmon JE. Targeted inhibition of complement activation prevents features of preeclampsia in mice. Kidney International 2011 Feb;79(3):331-339. PDF

Woods AK, Hoffmann DS, Weydert CJ, Butler SD, Zhou Y, Sharma RV, Davisson RL. Adenoviral delivery of VEGF121 early in pregnancy prevents spontaneous development of preeclampsia in BPH/5 mice. Hypertension 2011 Jan;57(1):94-102. PDF

Capone C, Faraco G, Park L, Cao X, Davisson RL, Iadecola C. The cerebrovascular dysfunction induced by slow pressor doses of angiotensin-ll precedes the development of hypertension. Am J Physiol Heart Circ Physiol 2011 Jan;300:H397-H407. PDF

Oliveira-Sales EB, Colombari DSA, Davisson RL, Kasparov S, Hirata AE, Campos RR, Paton JFR. Kidney-induced hypertension depends on superoxide signaling in the rostral ventrolateral medulla. Hypertension 2010 Aug; 56(2):290-296. PDF

Infanger DW, Cao X, Butler SD, Burmeister MA, Zhou Y, Stupinski JA, Sharma RV, Davisson RL. Silencing Nox4 in the paraventricular nucleus improves myocardial infarction-induced cardiac dysfunction by attenuating sympathoexcitation and periinfarct apoptosis. Circ Res 2010 June;106(11):1763-1774. PDF

Hingtgen SD, Li Z, Kutschke W, Tian X, Sharma RV, Davisson RL. Superoxide scavenging and AKT inhibition in the myocardium ameliorate pressure overload-induced NFkB activation and cardiac hypertrophy. Physiological Genomics 2010 Apr;41:127-136. PDF

Miller FJ Jr., Chu X, Stanic B, Tian X, Sharma RV, Davisson RL, Lamb FS. A differential role for endocytosis in receptor-mediated activation of Nox1. Antioxid Redox Signal 2010 Mar;12(5):583-593. PDF

Davisson RL, Zimmerman MC. Angiotensin II, Oxidant Signaling, and Hypertension. Down to a T? Hypertension 2010 Feb;55(2):228-230. PDF

Peterson JR, Burmeister MA, Tian X, Zhou Y, Guruju MR, Stupinski JA, Sharma RV, Davisson RL. Genetic silencing of Nox2 and Nox4 reveals differential roles of these NADPH oxidase homologues in the vasopressor and dipsogenic effects of brain angiotensin-II. Hypertension 2009 Nov;54(5):1106-1114. PDF

Ding Y, Li YL, Zimmerman MC, Davisson RL, Schultz HD. Role of CuZn superoxide dismutase on carotid body function in heart failure rabbits. Cardiovasc Res. 2009 Mar 1;81(4):678-85. PDF

Lindley TE, Infanger DW, Rishniw M, Zhou Y, Doobay MF, Sharma RV, Davisson RL. Scavenging superoxide selectively in mouse forebrain is associated with improved cardiac function and survival following myocardial infarction. Am J Physiol Regul Integr Comp Physiol. 2009 Jan;296(1):R1-8.
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Lazartigues E, Sinnayah P, Augoyard G, Gharib C, Johnson AK, Davisson RL. Enhanced water and salt intake in transgenic mice with brain-restricted overexpression of angiotensin (AT1) receptors. Am J Physiol Regul Integr Comp Physiol. 2008 Nov;295(5):R1539-45.
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Braga VA, Burmeister MA, Sharma RV, Davisson RL. Cardiovascular responses to peripheral chemoreflex activation and comparison of different methods to evaluate baroreflex gain in conscious mice using telemetry. Am J Physiol Regul Integr Comp Physiol. 2008 Oct;295(4):R1168-74.
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Iadecola C, Davisson RL. Hypertension and cerebrovascular dysfunction. Cell Metab. 2008 Jun;7(6):476-84. Review.
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Peterson JR, Infanger DW, Braga VA, Zhang Y, Sharma RV, Engelhardt JF, Davisson RL. Longitudinal noninvasive monitoring of transcription factoractivation in cardiovascular regulatory nuclei using bioluminescence imaging. Physiol Genomics. 2008 Apr 22;33(2):292-9.
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Hoffmann DS, Weydert CJ, Lazartigues E, Kutschke WJ, Kienzle MF, Leach JE, Sharma JA, Sharma RV, Davisson RL. Chronic tempol prevents hypertension, proteinuria, and poor feto-placental outcomes in BPH/5 mouse model of preeclampsia. Hypertension. 2008 Apr;51(4):1058-65. 
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Martin S, Markus MA, Morris BJ, Davisson RL, Lawrence AJ, van den Buuse M. Does angiotensin interact with dopaminergic mechanisms in the brain to modulate prepulse inhibition in mice? Neuropharmacology. 2008 Feb;54(2):399-404. 
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Moore R, Krstew EV, Kirchhoff J, Davisson RL, Lawrence AJ. Central overexpression of angiotensin AT(1A) receptors prevents dopamine D(2) receptor regulation of alcohol consumption in mice. Alcohol Clin Exp Res. 2007Jul;31(7):1128-37. 
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Sakai K, Agassandian K, Morimoto S, Sinnayah P, Cassell MD, Davisson RL, Sigmund CD. Local production of angiotensin II in the subfornical organ causes elevated drinking. J Clin Invest. 2007 Apr;117(4):1088-95. 
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Dajani R, Sanlioglu S, Zhang Y, Li Q, Monick MM, Lazartigues E, Eggleston T, Davisson RL, Hunninghake GW, Engelhardt JF. Pleiotropic functions of TNF-alpha determine distinct IKKbeta-dependent hepatocellular fates in response to LPS. Am J Physiol Gastrointest Liver Physiol. 2007 Jan;292(1):G242-52.
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Doobay MF, Talman LS, Obr TD, Tian X, Davisson RL, Lazartigues E. Differential expression of neuronal ACE2 in transgenic mice with overexpression of the brain renin-angiotensin system. Am J Physiol Regul Integr Comp Physiol. 2007 Jan;292(1):R373-81.
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Dokras A, Hoffmann DS, Eastvold JS, Kienzle MF, Gruman LM, Kirby PA, Weiss RM, Davisson RL. Severe feto-placental abnormalities precede the onset of hypertension and proteinuria in a mouse model of preeclampsia. Biol Reprod. 2006 Dec;75(6):899-907.
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Sinnayah P, Lazartigues E, Sakai K, Sharma RV, Sigmund CD, Davisson RL. Genetic ablation of angiotensinogen in the subfornical organ of the brain prevents the central angiotensinergic pressor response. Circ Res. 2006 Nov 10;99(10):1125-31.
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Infanger DW, Sharma RV, Davisson RL. NADPH oxidases of the brain: distribution, regulation, and function. Antioxid Redox Signal. 2006 Sep-Oct;8(9-10):1583-96. Review.
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Hingtgen SD, Tian X, Yang J, Dunlay SM, Peek AS, Wu Y, Sharma RV, Engelhardt  JF, Davisson RL. Nox2-containing NADPH oxidase and Akt activation play a key role in angiotensin II-induced cardiomyocyte hypertrophy. Physiol Genomics. 2006 Aug 16;26(3):180-91. 
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Ma X, Zhang HJ, Whiteis CA, Tian X, Davisson RL, Kregel KC, Abboud FM, Chapleau MW. NAD(P)H oxidase-induced oxidative stress in sympathetic ganglia of apolipoprotein E deficient mice. Auton Neurosci. 2006 Jun 30;126-127:285-91.
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Peterson JR, Sharma RV, Davisson RL. Reactive oxygen species in the neuropathogenesis of hypertension. Curr Hypertens Rep. 2006 Jun;8(3):232-41. Review.
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Sigmund CD, Davisson RL. Targeting brain AT1 receptors by RNA interference. Hypertension. 2006 Feb;47(2):145-6.
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Zimmerman MC, Sharma RV, Davisson RL. Superoxide mediates angiotensin II-induced influx of extracellular calcium in neural cells. Hypertension. 2005 Apr;45(4):717-23.
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Kurtz TW, Griffin KA, Bidani AK, Davisson RL, Hall JE; AHA Council on High Blood Pressure Research, Professional and Public Education Subcommittee. Recommendations for blood pressure measurement in animals: summary of an AHA scientific statement from the Council on High Blood Pressure Research, Professional and Public Education Subcommittee. Arterioscler Thromb Vasc Biol.2005 Mar;25(3):478-9.
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Kurtz TW, Griffin KA, Bidani AK, Davisson RL, Hall JE; Subcommittee of Professional and Public Education of the American Heart Association Council on High Blood Pressure Research. Recommendations for blood pressure measurement in humans and experimental animals: part 2: blood pressure measurement in experimental animals: a statement for professionals from the Subcommittee of Professional and Public Education of the American Heart Association Council on High Blood Pressure Research. Arterioscler Thromb Vasc Biol. 2005 Mar;25(3):e22-33.
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Kurtz TW, Griffin KA, Bidani AK, Davisson RL, Hall JE; Subcommittee of Professional and Public Education of the American Heart Association. Recommendations for blood pressure measurement in humans and experimental animals. Part 2: Blood pressure measurement in experimental animals: a statement  for professionals from the subcommittee of professional and public education of the American Heart Association council on high blood pressure research. Hypertension. 2005 Feb;45(2):299-310.
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Lazartigues E, Lawrence AJ, Lamb FS, Davisson RL. Renovascular hypertension in mice with brain-selective overexpression of AT1a receptors is buffered by increased nitric oxide production in the periphery. Circ Res. 2004 Sep 3;95(5):523-31.
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Zimmerman MC, Dunlay RP, Lazartigues E, Zhang Y, Sharma RV, Engelhardt JF, Davisson RL. Requirement for Rac1-dependent NADPH oxidase in the cardiovascular and dipsogenic actions of angiotensin II in the brain. Circ Res. 2004 Sep 3;95(5):532-9.
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Zimmerman MC, Lazartigues E, Sharma RV, Davisson RL. Hypertension caused by angiotensin II infusion involves increased superoxide production in the central nervous system. Circ Res. 2004 Jul 23;95(2):210-6. PubMed
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Sinnayah P, Lindley TE, Staber PD, Davidson BL, Cassell MD, Davisson RL. Targeted viral delivery of Cre recombinase induces conditional gene deletion in cardiovascular circuits of the mouse brain. Physiol Genomics. 2004 Jun 17;18(1):25-32.
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Lindley TE, Doobay MF, Sharma RV, Davisson RL. Superoxide is involved in the central nervous system activation and sympathoexcitation of myocardial infarction-induced heart failure. Circ Res. 2004 Feb 20;94(3):402-9.
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Ma X, Sigmund CD, Hingtgen SD, Tian X, Davisson RL, Abboud FM, Chapleau MW. Ganglionic action of angiotensin contributes to sympathetic activity in renin-angiotensinogen transgenic mice. Hypertension. 2004 Feb;43(2):312-6.
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Zimmerman MC, Davisson RL. Redox signaling in central neural regulation of cardiovascular function. Prog Biophys Mol Biol. 2004 Feb-Apr;84(2-3):125-49. Review.
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Yue Y, Li Z, Harper SQ, Davisson RL, Chamberlain JS, Duan D. Microdystrophin gene therapy of cardiomyopathy restores dystrophin-glycoprotein complex and improves sarcolemma integrity in the mdx mouse heart. Circulation. 2003 Sep 30;108(13):1626-32..
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Davisson RL. Physiological genomic analysis of the brain renin-angiotensin system. Am J Physiol Regul Integr Comp Physiol. 2003 Sep;285(3):R498-511. Review.
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Li Z, Sharma RV, Duan D, Davisson RL. Adenovirus-mediated gene transfer to adult mouse cardiomyocytes is selectively influenced by culture medium. J Gene Med. 2003 Sep;5(9):765-72..
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Yang J, Marden JJ, Fan C, Sanlioglu S, Weiss RM, Ritchie TC, Davisson RL, Engelhardt JF. Genetic redox preconditioning differentially modulates AP-1 and NF kappa B responses following cardiac ischemia/reperfusion injury and protects against necrosis and apoptosis. Mol Ther. 2003 Mar;7(3):341-53.
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Zimmerman MC, Lazartigues E, Lang JA, Sinnayah P, Ahmad IM, Spitz DR, Davisson RL. Superoxide mediates the actions of angiotensin II in the central nervous system. Circ Res. 2002 Nov 29;91(11):1038-45..
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Lazartigues E, Dunlay SM, Loihl AK, Sinnayah P, Lang JA, Espelund JJ, Sigmund CD, Davisson RL. Brain-selective overexpression of angiotensin (AT1) receptors causes enhanced cardiovascular sensitivity in transgenic mice. Circ Res. 2002 Mar 22;90(5):617-24.
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Sinnayah P, Lindley TE, Staber PD, Cassell MD, Davidson BL, Davisson RL. Selective gene transfer to key cardiovascular regions of the brain: comparison of two viral vector systems. Hypertension. 2002 Feb;39(2 Pt 2):603-8.
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Davisson RL, Hoffmann DS, Butz GM, Aldape G, Schlager G, Merrill DC, Sethi S, Weiss RM, Bates JN. Discovery of a spontaneous genetic mouse model of preeclampsia. Hypertension. 2002 Feb;39(2 Pt 2):337-42.
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Morimoto S, Cassell MD, Beltz TG, Johnson AK, Davisson RL, Sigmund CD. Elevated blood pressure in transgenic mice with brain-specific expression of human angiotensinogen driven by the glial fibrillary acidic protein promoter. Circ Res. 2001 Aug 17;89(4):365-72.

Hingtgen SD, Davisson RL. Gene therapeutic approaches to oxidative stress-induced cardiac disease: principles, progress, and prospects. Antioxid Redox Signal. 2001 Jun;3(3):433-49. Review.
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Butz GM, Davisson RL. Long-term telemetric measurement of cardiovascular parameters in awake mice: a physiological genomics tool. Physiol Genomics. 2001 Mar 8;5(2):89-97.
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Straub V, Donahue KM, Allamand V, Davisson RL, Kim YR, Campbell KP. Contrast  agent-enhanced magnetic resonance imaging of skeletal muscle damage in animal models of muscular dystrophy. Magn Reson Med. 2000 Oct;44(4):655-9.
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Allamand V, Donahue KM, Straub V, Davisson RL, Davidson BL, Campbell KP. Early adenovirus-mediated gene transfer effectively prevents muscular dystrophy in alpha-sarcoglycan-deficient mice. Gene Ther. 2000 Aug;7(16):1385-91.
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Davisson RL, Oliverio MI, Coffman TM, Sigmund CD. Divergent functions of angiotensin II receptor isoforms in the brain. J Clin Invest. 2000 Jul;106(1):103-6.
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Hill JA, Karimi M, Kutschke W, Davisson RL, Zimmerman K, Wang Z, Kerber RE, Weiss RM. Cardiac hypertrophy is not a required compensatory response to short-term pressure overload. Circulation. 2000 Jun 20;101(24):2863-9. PubMed PMID: 10859294.
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Coral-Vazquez R, Cohn RD, Moore SA, Hill JA, Weiss RM, Davisson RL, Straub V, Barresi R, Bansal D, Hrstka RF, Williamson R, Campbell KP. Disruption of the sarcoglycan-sarcospan complex in vascular smooth muscle: a novel mechanism for cardiomyopathy and muscular dystrophy. Cell. 1999 Aug 20;98(4):465-74.
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Stec DE, Davisson RL, Haskell RE, Davidson BL, Sigmund CD. Efficient liver-specific deletion of a floxed human angiotensinogen transgene by adenoviral delivery of Cre recombinase in vivo. J Biol Chem. 1999 Jul 23;274(30):21285-90.
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Davisson RL, Ding Y, Stec DE, Catterall JF, Sigmund CD. Novel mechanism of hypertension revealed by cell-specific targeting of human angiotensinogen in transgenic mice. Physiol Genomics. 1999 Jul 15;1(1):3-9.
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Davisson RL, Yang G, Beltz TG, Cassell MD, Johnson AK, Sigmund CD. The brain  renin-angiotensin system contributes to the hypertension in mice containing both the human renin and human angiotensinogen transgenes. Circ Res. 1998 Nov 16;83(10):1047-58.
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Stec DE, Davisson RL, Sigmund CD. Transgenesis and gene targeting in the mouse; tools for studying genetic determinants of hypertension. Trends Cardiovasc Med. 1998 Aug;8(6):256-64.
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Colombari E, Davisson RL, Shaffer RA, Talman WT, Lewis SJ. Hemodynamic effects of L-glutamate in NTS of conscious rats: a possible role of vascular nitrosyl factors. Am J Physiol. 1998 Apr;274(4 Pt 2):H1066-74.
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Ding Y, Davisson RL, Hardy DO, Zhu LJ, Merrill DC, Catterall JF, Sigmund CD. The kidney androgen-regulated protein promoter confers renal proximal tubule cell-specific and highly androgen-responsive expression on the human angiotensinogen gene in transgenic mice. J Biol Chem. 1997 Oct 31;272(44):28142-8.
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Travis MD, Davisson RL, Bates JN, Lewis SJ. Hemodynamic effects of L- and D-S-nitroso-beta,beta-dimethylcysteine in rats. Am J Physiol. 1997 Sep;273(3 Pt 2):H1493-501.
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Chatterjee TK, Liu X, Davisson RL, Fisher RA. Genomic organization of the rat pituitary adenylate cyclase-activating polypeptide receptor gene. Alternative splicing within the 5'-untranslated region. J Biol Chem. 1997 May 2;272(18):12122-31.
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Davisson RL, Possas OS, Murphy SP, Lewis SJ. Neurogenically derived nitrosyl factors mediate sympathetic vasodilation in the hindlimb of the rat. Am J Physiol. 1997 May;272(5 Pt 2):H2369-76.
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Davisson RL, Travis MD, Bates JN, Johnson AK, Lewis SJ. Stereoselective actions of S-nitrosocysteine in central nervous system of conscious rats. Am J Physiol. 1997 May;272(5 Pt 2):H2361-8.
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Davisson RL, Kim HS, Krege JH, Lager DJ, Smithies O, Sigmund CD. Complementation of reduced survival, hypotension, and renal abnormalities in angiotensinogen-deficient mice by the human renin and human angiotensinogen genes. J Clin Invest. 1997 Mar 15;99(6):1258-64.
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Davisson RL, Sigmund CD. Transgenic animal models as tools for studying renal developmental physiology. Pediatr Nephrol. 1996 Dec;10(6):798-803. Review.
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Davisson RL, Nuutinen N, Coleman ST, Sigmund CD. Inappropriate splicing of a  chimeric gene containing a large internal exon results in exon skipping in transgenic mice. Nucleic Acids Res. 1996 Oct 15;24(20):4023-8.
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Davisson RL, Bates JN, Johnson AK, Lewis SJ. Use-dependent loss of acetylcholine- and bradykinin-mediated vasodilation after nitric oxide synthase inhibition. Evidence for preformed stores of nitric oxide-containing factors in vascular endothelial cells. Hypertension. 1996 Sep;28(3):354-60. PubMed PMID:8794816.
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Davisson RL, Shaffer RA, Johnson AK, Lewis SJ. Use-dependent loss of active sympathetic neurogenic vasodilation after nitric oxide synthase inhibition in conscious rats. Evidence for the presence of preformed stores of nitric oxide-containing factors. Hypertension. 1996 Sep;28(3):347-53. PubMed PMID: 8794815.
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Davisson RL, Travis MD, Bates JN, Lewis SJ. Hemodynamic effects of L- and D-S-nitrosocysteine in the rat. Stereoselective S-nitrosothiol recognition sites. Circ Res. 1996 Aug;79(2):256-62. PubMed PMID:8756002.
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Davisson RL, Shaffer RA, Johnson AK, Lewis SJ. Stimulation of lumbar sympathetic nerves may produce hindlimb vasodilation via the release of pre-formed stores of nitrosyl factors. Neuroscience. 1996 Jun;72(4):881-7.
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Davisson RL, Johnson AK, Lewis SJ. Nitrosyl factors mediate active neurogenic hindquarter vasodilation in the conscious rat. Hypertension. 1994 Jun;23(6 Pt 2):962-6.
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Davisson RL, Walton TM, Johnson AK, Lewis SJ. Cardiovascular effects produced by systemic injections of nitro blue tetrazolium in the rat. Eur J Pharmacol. 1993 Sep 7;241(1):135-7.
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