Cartilage biology and the development of arthritis.

Cartilage provides the protective covering on the ends of bones and allows for pain-free joint movement. When injured, cartilage has a very limited intrinsic capacity for repair, and the end result is frequently arthritis. In the equine athlete, arthritis leads to joint pain, lameness, and loss of performance with associated economic losses.

Normal shoulder cartilage.        Shoulder with arthritis.

Our laboratory investigates the underlying cellular and molecular mechanisms involved in the development of arthritis with the ultimate goal of identifying novel molecular targets for the treatment or prevention of arthritis.

Current laboratory projects include:

  1. Equine embryonic stem cells
  2. The role of Rho-subfamily GTPases in cartilage homeostasis
  3. Tetracyclines as therapeutics for arthritis
  4. Platelet rich plasma for tendon and suspensory ligament regeneration

For more information,

Dr. Lisa Fortier:   Faculty Page | Publications