Paul R. Bowser
Dr. Bowser is a Professor in the Department of Microbiology and Immunology
and has been associated with the department since 1995 (previously an
associate professor in the Department of Avian and Aquatic Animal Medicine,
1985-1995). He also served as an aquatic animal health specialist on the
faculty of the College of Veterinary Medicine at Mississippi State University
(1980-85) and with the Aquaculture Program of the University of California,
Davis (1978-80). He received the MS degree from Iowa State University
in 1972. He then received his PhD from Auburn University in 1978 . He
has obtained continuous funding (USDA, NY Sea Grant, etc.) throughtout
his career to study diseases of fishes and strategies for fish health
management.
Research Interests
| Graduate Fields | Lab
Members | Related Links | Selected
References
Research Interests
General interests include
infectious and non-infectious diseases of fishes and strategies
for fish health management. Our recent major research efforts have
been in the following areas:
Retroviral-Caused tumors in Fish. In a collaborative
effort with the Laboratory of Dr. James Casey, we have studied the
pathogenesis of walleye dermal sarcoma retrovirus, two viruses associated
with walleye discrete epidermal hyperplasia, and the Atlantic salmon
swim bladder sarcoma virus. Within these efforts, we have been trying
to understand the mechanisms by which these tumors and tumor viruses
show a seasonality in their pathogenesis.
Therapeutants for Cultured Food Fishes. The commercial
aquaculture industry suffers from very limited access to FDA approved
therapeutants for controlling diseases in the production environment.
Our laboratory is part of the NRSP7 – Minor Use Animal Drug
Program. This program is a joint USDA/FDA/University/Industry effort
to address the critical needs for safe and effective compounds for
health management in minor species food and fiber animals. Much
of our recent efforts have been in comparative pharmacokinetic studies
in different species of fish of candidate antibacterials with promise
for use in aquaculture. Our ultimate goal is to develop data that
will support a species grouping concept for aquaculture species.
The current regulatory environment for approval of a therapeutant
requires that all work be performed in the species for which the
drug label is being sought. A species grouping concept would greatly
reduce the cost of obtaining labels for the variety of fish cultured
in the US.
Diagnostic Investigations. Our laboratory operates
the Fish Disease Diagnostic Laboratory, a service laboratory providing
disease diagnostic assistance to the aquaculture community, research
community and fish hobbyist in New York State. We also assist the
New York State Department of Environmental Conservation in investigations
of fish kills in wild fish populations in the state. Many times
these diagnostic investigations lead to more in-depth research investigations
in fish health issues.
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Walleye (Sander vitreus) with walleye dermal sarcoma |
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Grass carp (Ctenophayngodon idella) with spinal deformity |
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Lake Sturgeon (Acipenser fluvescens) diagnostic case submission from the Niagara River |
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Graduate Fields
Dr. Bowser is a member of the following Graduate Fields:
Comparative Biomedical Sciences
Environmental Toxicology
Lab Members
Dr. Rodman G. Getchell, Research Associate
Dr. Geoffrey H. Groocock, Extension Associate
Gregory A. Wooster, Research Support Specialist
Steven A. Frattini, Veterinary Student
Katherine "Holly" Kohler, Veterinary Student
Related Links
Aquatic Animal Health Program
AQUAVET Program
Marine Disease and Pathology Consortium Laboratory at the School of Marine and Atmospheric Sciences, Stony Brook University
Selected References
Dove, A.D.M, M.S. Sokolowski, S.L. Bartlett and P.R. Bowser. (2005). Spatio-temporal
variation in serum chemistry of the lobster, Homarus americanus Milne-Edwards.
J.
Fish Diseases 28:663-675.
Paul, T.A., S.L. Quackenbush, C. Sutton, R.N. Casey, P.R. Bowser, and
J.W. Casey. (2006). Identification and Characterization of an exogenous
retrovirus from Atlantic salmon swim bladder sarcoma. J.
Virology 80:2941-2948.
Perez-Fuentetaja, A., M.D. Clapsadl, D. Einhouse, P.R. Bowser, R.G. Getchell
and W.T. Lee. (2006). Influence of limnological conditions on Clostridium
botulinum Type E presence in Eastern Lake Erie Sediments (Great Lakes,
USA). Hydrobiologia
563:189-200.
Grimmett, S.G., J.V. Warg, R.G. Getchell, D.J. Johnson and P.R. Bowser.
(2006). An unsusual koi herpesvirus associated with a mortality event
of common carp Cyprinus carpio in New York State, USA. J.
Wildlife Diseases 42:658-662.
Topic-Popovic, N. J.G. Babish and P.R. Bowser. (2007). Observational
study of hepatic cytochrome P-450 protein expression and activity in summer
flounder (Paralichtys dentatus) following combination ormetoprim-sulfadimetoxine
treatment. Chemotherapy 53:3113-315.
Meseck, E.K., T.W. French, S.G. Grimmett, S.L. Bartlett, G.A. Wooster,
R.G. Getchell, and P.R. Bowser. (2007). Gross and microscopic pathology
of large cavernous lesions found in muscle of Chinook salmon (Oncorhynchus
tshawytscha) from Lake Ontario. Journal of Wildlife Diseases (in press).
