Department of Microbiology and Immunology


Brian Rudd

Picture of Dr. Brian RuddAssistant Professor of Immunology

Cornell University College of Veterinary Medicine
C5 147 Veterinary Medical Center
E-mail: bdr54@cornell.edu
Phone: 607-253-4418

PhD (University of Michigan)

Dr. Rudd, an Assistant Professor in the Department of Microbiology and Immunology, received his Bachelor of Science from James Madison University and his MPH and PhD from the University of Michigan.  During his post-doctoral fellowship, he investigated the underlying basis for increased susceptibility to pathogens at the extreme ends of the lifespan.

Research Interests

My lab seeks to better understand why individuals in early life are more susceptible to infection than adults and respond poorly to vaccination.  While the underlying basis for this increase in susceptibility is not known, many reports have indicated that it is due to quantitative and qualitative differences in neonatal T lymphocytes.  We believe these differences arise from altered programs of T cell production and maintenance during early stages of development.  In early life, there is a greater proportion of immature recent thymic emigrants, more extensive homeostatic proliferation of naïve T cells, different hematopoietic precursors, and a smaller repertoire of T cells.  We are currently using neonatal mouse models of infectious diseases to determine the relative contribution of these differences toward impaired adaptive immune responses.  The goal of my research is to identify the most critical primary defects in neonatal T cells, as well as to uncover the mechanisms that underlie such defects.  Knowledge gained from these studies will then be used to design more effective therapeutic interventions and vaccines that can be safely administered in early life. 

 

Graduate Fields

Dr. Rudd is a member of the following Graduate Fields:

 

Lab Members

Wisler Charles, Graduate Student
Kito Nzingha, Technical Support
Norah Smith, Postdoctoral Associate
Jocelyn (Jie) Wang, Graduate Student

 

Related Links

 

Selected References

Smith NL, Wissink E, Wang J, Pinello JF, Davenport MP, Grimson A, Rudd BD. (2014).  Rapid Proliferation and Differentiation Impairs the Development of Memory CD8+ T Cells in Early Life. Journal of Immunology. PMID:  24850719 [Epub ahead of print]

Rudd BD, Venturi V, Smith NL, Nzingha K, Goldberg EL, et al. (2013). Acute Neonatal Infections ‘Lock-In’ a Suboptimal CD8+ T Cell Repertoire with Impaired Recall Responses. PLoS Pathog. 9(9): e1003572. doi:10.1371/journal.ppat.1003572.

Rudd BD, Venturi V, Li G, Samadder P, Ertelt J, Way SS, Davenport MP, Nikolich-Zugich, J.  (2011).  Non-random attrition of the naïve CD8+ T-cell pool with aging governed by TCR:pMHC interations.  Proceedings of the National Academy of Science (PNAS).  108:13694-13699. 

Rudd BD, Venturi V, Davenport MP and Nikolich-Zugich J.  (2011).  Evolution of the antigen-specific CD8+ T cell repertoire across the entire lifespan: Evidence for clonal homogenization of the old TCR repertoire.  Journal of Immunology.  186:2056-2064.

Nikolich-Zugich J & Rudd BD.  (2010).  Immune memory and aging: an infinite or finite resourceCurrent Opinions in Immunology.  22:535-540.

Rudd BD, Venturi V, Smithy MJ, Way SS, Davenport MP and Nikolich-Zugich J.  (2010). Diversity of the CD8+ T cell repertoire elicited against an immunodominant epitope does not depend on the context of infection.  Journal of Immunology.  184:2958-2965.