Wayne Schwark
Current Position
Professor of Pharmacology, Department of Molecular Medicine, Cornell University

Graduate Education
D.V.M., Ontario Veterinary College, University of Guelph, Guelph, Ontario.
M.Sc. in Pharmacology, Department of Physiology and Pharmacology, Ontario Veterinary College, University of Guelph, Guelph, Ontario.
Ph.D. in Pharmacology, Department of Pharmacology, Medical College, University of Ottawa, Ottawa, Ontario.

Honors and Awards
- Norden Distinguished Teacher Award, Cornell University, 1983, 1989
- Fogarty Senior International Fellowship, 1984
- Phi Zeta (Veterinary Honor Society), 1973
- Sigma Xi (Scientific Research Society), 1975



Publications
S.E. Eltom and W.S. Schwark. CYP1A1 and CYP1B1, two hydrocarbon-inducible P450's, are constitutively expressed in neonatal and adult goat liver, lung and kidney. Pharm. Tox. In press (1999).

L.J. Smith, W.S. Schwark, R. Cook, P.F. Moon and A.L. Looney. Pharmacokinetic properties of intravenously administered mivacurium chloride in dogs. Amer J. Vet. Res. In press (1999).

L.A. Trepanier, A. Van Schoick, W.S. Schwark and J. Carrillo. Therapeutic serum drug concentrations in epileptic dogs treated with potassium bromide alone or in combination with other anticonvulsants: 122 cases (1992-1996). J. Amer. Vet. Med. Assoc. 213: 1449-1453 (1998).

M.A. Ball, W.C. Rebhun, L. Trepanier, J. Gaarder, W.S. Schwark. Corneal concentrations and preliminary toxicological evaluation of an itraconazole/dimethyl sulphoxide ophthalmic ointment. J. Vet. Pharmacol. Ther. 20: 100-104 (1997).

C. Brayton and W. Schwark. Use and misuse of DMSO. In: "Current Veterinary Therapy". Vol. 12. W. B. Saunders Co., Philadelphia. (1994).

P. A. Wilkins, N.G. Ducharme, J. E. Lowe, W. S. Schwark, C. Meschter and H. N. Erb. Measurements of blood flow and xanthine oxidase activity during postischemic reperfusion injury in the large colon of ponies. Amer. J. Vet. Res. 55: 1168-1177 (1994).

S. E. Eltom, S. S. Park and W. S. Schwark. Studies on the ontogeny of goat hepatic cytochrome P-450 associated o-dealkylase activities using monoclonal antibodies; comparison to adult lung activity. Dev. Pharmacol. Therap. 20: 93-99 (1993).

W. Schwark. Teaching an elective course and rounds in clinical pharmacology. Proc. 8th Bienn. Symp. Vet. Pharmacol. Therap. 8: 131-140 (1993).

S. E. Eltom, J. G. Babish and W. S. Schwark. The postnatal development of drug-metabolizing enzymes in hepatic, pulmonary and renal tissues of the goat. J. Vet. Pharmacol. Therap. 16: 152-163 (1993).

S. E. Eltom, C. L. Guard and W. S. Schwark. The effect of age on phenylbutazone pharmacokinetics, metabolism and plasma protein binding in goats. J. Vet. Pharmacol. Therap. 16: 141-151 (1993).

T. M. Byrem, T. F. Robinson, Y. R. Boisclair, A. W. Bell, W. S. Schwark and D. H. Beerman. Analysis and pharmacokinetics of cimaterol in growing Holstein steers. J. Anim. Sci. 70: 3812-3819 (1992).

P. M. Vancutsem and W. S. Schwark. Effects of fluoroquinolone antimicrobials alone and in conjunction with theophylline on seizures in amygdaloid kindled rats. Mechanistic and pharmacokinetic study. Epilepsy Res. In press (1992).

W. S. Schwark. Factors that affect drug disposition in food-producing animals during maturation. J. Anim. Sci. 70: 3635-3645 (1992).

R. O. Gilbert and W. S. Schwark. Pharmacologic considerations in the management of peripartum conditions in the cow. Vet. Clin. North America; Food Anim. Pract. 8: 29-56 (1992).

P. M. Vancutsem, J. G. Babish and W. S. Schwark. The fluoroquinolone antimicrobials: Structure, antimicrobial activity, pharmacokinetics, clinical use in domestic animals and toxicity. Cornell Vet 80:173-186 (1990).

S. E. Shoaf, W. S. Schwark and C. L. Guard. Pharmacokinetics of sulfadiazine/trimethoprim in neonatal male calves: effect of age and penetration into cerebrospinal fluid. Amer. J. Vet. Res., 80: 396-403 (1989).

C. L. Guard, K. W. BYMAN AND W. Schwark Effect of experimental synovitis on disposition of penicillin and oxytetracyline in neonatal calves. Cornell Vet. 79: 161-171 (1989).

M. C. Heit and W. S. Schwark. Pharmacological studies with a GABA uptake inhibitor in rats with kindled seizures in the amygdala. Neuropharmacology 27: 367-374 (1988).

C. Guard, W. Schwark, D. Kelton and A. Dobson. Effects of metoclopramide, clenbuterol and butorphanol on ruminoreticular motility of calves. Cornell Vet. 78: 89-98 (1988).

S. E. Shoaf, W. S. Schwark and C. L. Guard. The effect of age and diet on sulfadiazine/trimethoprim disposition following oral and subcutaneous administration to calves. J. Vet. Pharmacol. Therap. 10: 331-345 (1987).

M. C. Heit and W. S. Schwark. An efficient method for time course studies of antiepileptic drugs using the kindled rat seizure model. J. Pharmacol. Methods 18: 319-325 (1987).

S. E. Shoaf, W. S. Schwark, C. L. Guard and J. G. Babish. The development of hepatic drug-metabolizing enzyme activity in the neonatal calf and its effect on drug disposition. Drug Metab. Dispos. 15:676-681 (1987).

W. Löscher and W. S. Schwark. Further evidence for abnormal GABAergic circuits in amygdala-kindled rats. Brain Res. 420: 385-390 (1987).

W. S. Schwark and M. Haluska. Prophylaxis of amygdala kindling-induced epileptogenesis: Comparison of a GABA uptake inhibitor and diazepam. Epilepsy Res. 1: 63-69 (1987).

P. Pion, J. Babish, W. Schwark and W. Hornbuckle. Pharmacokinetics and electrocardiographic effects of verapamil in the cat. Proc. 5th Symp. Amer. Acad. Vet. Pharmacol. 5: 141-153 (1986).

S. E. Shoaf, W. S. Schwark, C. L. Guard and R. V. Schwartsman. Pharmacokinetics of trimethoprim/sulfadiazine in neonatal calves; influence of synovitis. J. Vet. Pharmacol. Therap. 9: 446-454 (1986).

W. S. Schwark, H. -H. Frey and S. J. Czuczwar. Effect of opiates on the parameters of seizures in rats with full amygdaloid-kindled convulsions. Neuropharmacology 25: 839-844 (1986).

C. L. Guard, W. S. Schwark, D. S. Friedman, P. Blackshear and M. Haluska. Age-related alterations in trimethoprim-sulfadiazine disposition following oral or parenteral administration in calves. Can. J. Vet. Res. 50: 342-346 (1986).

W. S. Schwark and M. Haluska. Prevention of amygdala kindling with an inhibitor of g-aminobutyric acid uptake. Neurosci. Lett. 69: 65-69 (1986).

W. S. Schwark. Cretinism, Model No. 133, Supplemental Update, 1985. In: "Handbook: Animal Models of Human Disease". Fasc 14. C.C. Capen, T.C. Jones and G. Migaki (eds.) Registry of Comparative Pathology, Armed Forces Institute of Pathology, Washington, D.C. (1985).

J. A. Teare, W. S. Schwark, S. J. Shin and D. L. Graham. Pharmacokinetics of a long-acting oxytetracycline preparation in ring-necked pheasants, great horned owls and Amazon parrots. Amer. J. Vet. Res. 46: 2639-2643 (1985).

W. Löscher and W. S. Schwark. Development of tolerance to the anticonvulsant effect of diazepam in amygdala-kindled rats. Expt. Neurol. 90: 373-384 (1985).

W. Löscher and W. S. Schwark. Evidence for impaired GABAergic activity in the substantia nigra of amygdaloid kindled rats. Brain Res. 339: 146-150 (1985).

W. S. Schwark, M. Haluska, P. Blackshear and T. Magana. Lifetime lead intoxication: Influence on the amygdaloid kindling model of epileptogenesis. Toxicology 36: 49-60 (1985).

W. Löscher and W. S. Schwark. Evaluation of different GABA receptor agonists in the kindled amygdala seizure model in rats. Expt. Neurol. 89: 454-460 (1985).

W. S. Schwark and W. Löscher. Comparison of the anticonvulsant effects of two novel GABA uptake inhibitors and diazepam in amygdaloid kindled rats. Naunyn-Schmiedeberg's Arch. Pharmacol. 329: 367-371 (1985).

C. L. Guard and W. S. Schwark. Influence of yohimbine on xylazine-induced depression of central nervous, gastrointestinal and cardiovascular function in the calf. Cornell Vet. 74: 312-321 (1984).

N. Shoulberg and W. S. Schwark. Cats and pharmaceuticals. In: "Cornell Feline Health Center Veterinary News". 5 pp., Summer, 1984.

N. G. Ducharme, S. G. Dill, S. J. Shin, W. S. Schwark, G. R. Ducharme and W. W. Beilman. Phenoxymethyl penicillin in the horse: An alternative to parenteral administration of penicillin. Can. J. Comp. Med. 47: 436-439 (1983).

W. S. Schwark, N. G. Ducharme, S. J. Shin, W. T. Beilman and J. T. Elwell. Absorption and distribution patterns oral phenoxymethyl penicillin (Penicillin V) in the horse. Cornell Vet. 73: 314-322 (1983).

W. S. Schwark, M. Haluska, K. Powell and P. Blackshear. Lead intoxication and the amygdaloid kindling model of epileptogenesis in the adult rat. Neurobehav. Toxicol. Teratol. 5: 325-329 (1983).

J. P. Fabisiak and W. S. Schwark. Aspects of the pentylenetetrazol kindling model of epilepsy in the rat. Expt. Neurol. 78: 7-14 (1982).

K. E. Munkenbeck and W. S. Schwark. Serotonergic mechanisms in amygdaloid-kindled seizures in the rat. Expt. Neurol. 76: 246-253 (1982).

J. P. Fabisiak and W. S. Schwark. Cerebral free amino acids in the amygdaloid kindling model of epilepsy. Neuropharmacology 21: 179-182 (1982).

M. A. Goldstein, W. S. Schwark, C. E. Short and K. K. White. Cardiopulmonary resuscitation in the horse. Cornell Vet. 71: 255-268 (1981).

D. A. Callaghan and W. S. Schwark. Pharmacological modification of amygdaloid kindled seizures. Neuropharmacology 19: 1132-1136 (1980).

D. L. Rowe-Murphy, A. Van Tienhoven, N. R. Scott, P. E. Hillman, C. L. Wood, A. L. Johnson and W. S. Schwark. Effect of 6-hydroxydopamine and pimozide on temperature maintenance by the chicken. Amer. J. Physiol. 239: R296-R302 (1980).

A. L. Aronson and W. S. Schwark. Adverse drug reactions. In: "Current Veterinary Therapy". Vol. 7, R. W. Kirk (ed.) W. B. Saunders Co., Philadelphia, pp. 155-160 (1980).

D. A. Callaghan and W. S. Schwark. Involvement of catecholamines in kindled amygdaloid convulsions in the rat. Neuropharmacology 18: 541-545 (1979).

W. S. Schwark. Cretinism, Model No. 133. In: "Handbook: Animal Models of Human Disease". Fasc 7, T. C. Jones, D. B. Hackel and G. Migaki (eds.) Registry of Comparative Pathology, Armed Forces Institute of Pathology, Washington, D.C. (1978).

W. S. Schwark and R. R. Keesey. Altered thyroid function and synaptosomal uptake of serotonin in developing rat brain. J. Neurochem. 30: 1583-1586 (1978).

R. G. Ellis, J. E. Lowe, W. S. Schwark and J. I. Taylor. Intravenously administered xylazine and ketamine HC1 for anesthesia in horses. J. Equine Med. Surg. 1: 259-265 (1977).

W. S. Schwark. Animal model of human disease. Cretinism. Amer. J. Pathol. 87: 473-476 (1977).

W. S. Schwark and R. R. Keesey. Cretinism: Influence on rate-limiting enzymes of amine synthesis in rat brain. Life Sci. 19: 1699-1704 (1976).

W. S. Schwark and R. R. Keesey. Influence of thyroid hormone on norepinephrine metabolism in rat brain during maturation. Res. Commun. Chem. Pathol. Pharmacol. 13: 673-683 (1976).

W. S. Schwark and R. R. Keesey. Thyroid hormone control of serotonin in developing rat brain. Res. Commun. Chem. Pathol. Pharmacol. 10: 37-50 (1975).

W. S. Schwark. Pharmacologic management of allergic diseases. Vet. Clin. North America 4: 57-64 (1974).

W. S. Schwark, R. L. Singhal and G. M. Ling. Glyceraldehyde 3-phosphate dehydrogenase activity in developing brain during experimental cretinism. Biochim. Biophys. Acta 273: 308-317 (1972).

W. S. Schwark, R. L. Singhal and G. M. Ling. Metabolic control mechanisms in mammalian systems. XVII. Thyroid hormone control of brain hexose monophosphate shunt enzymes during experimental cretinism. Brain Res. 42: 103-116 (1972).

W. S. Schwark, R. L. Singhal and G. M. Ling. Metabolic control mechanisms in mammalian systems. Regulation of key glycolytic enzymes in developing brain during experimental cretinism. J. Neurochem. 19: 1171-1182 (1972).

W. S. Schwark, R. L. Singhal and G. M. Ling. Metabolic control mechanisms in mammalian systems. XIII. Thyroid hormone control of a-glycerophosphate dehydrogenase activity in rat cerebral cortex and cerebellum. Can. J. Physiol. Pharmacol. 49: 598-607 (1971).

W. S. Schwark, R. L. Singhal and G. M. Ling. Metabolic control mechanisms in mammalian systems. Regulation of pyruvate kinase in the rat cerebral cortex. J. Neurochem. 18: 123-134 (1971).

R. Vijayvargiya, W. S. Schwark and R. L. Singhal. Metabolic control mechanisms in mammalian systems. XI. Pyruvate kinase modulation in the rat prostate and seminal vesicles. Can. J. Biochem. 48: 1268-1277 (1970).

W. S. Schwark, R. L. Singhal and G. M. Ling. Cerebro-cortical pyruvate kinase inhibition by L-phenylalanine and p-chlorophenylalanine. Life Sci. 9: 939-945 (1970).

R. L. Singhal, J. R. E. Valadares and W. S. Schwark. Metabolic control mechanisms in mammalian systems. IX. Estrogen-like stimulation of uterine enzymes by o, p-1,1,1-trichloro-2-2-bis (p-chlorophenyl) ethane. Biochem. Pharmacol. 19: 2145-2155 (1970).

W. S. Schwark, R. L. Singhal and G. M. Ling. Free fatty acid inhibition of a-glycerophosphate dehydrogenase activity in rat brain. J. Pharm. Pharmacol. 22: 458-460 (1970).

W. S. Schwark, R. L. Singhal and G. M. Ling. Metabolic control mechanisms in mammalian systems. VIII. Estrogenic induction of fructose-1,6-diphosphate aldolase in the rat uterus. Biochim. Biophys. Acta 192: 106-117 (1969).

R. Vijayvargiya, W. S. Schwark and R. L. Singhal. Pyruvate kinase: Modulation by L-phenylalanine and L-alanine. Can. J. Biochem. 47: 895-898 (1969).

W. S. Schwark and D. J. Ecobichon. Perinatal development of rat liver and kidney esterases. Biochem. Pharmacol. 18: 915-921 (1969).

R. L. Singhal, J. R. E. Valadares and W. S. Schwark. Inhibition by phenobarbitone of oestrogen-stimulated increases in uterine enzymes. J. Pharm. Pharmacol. 21: 194-195 (1969).

W. S. Schwark and D. J. Ecobichon. Subcellular localization and drug-induced changes of rat liver and kidney esterases. Can. J. Physiol. Pharmacol. 46: 207-212 (1968).

W. S. Schwark and D. J. Ecobichon. Characterization of rat liver and kidney esterases. Can. J. Biochem. 45: 451-455 (1967).



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