Infection and Pathobiology

Catfish
Toxoplasma gondii infecting macrophages
Baby ducks
Rooster (mixed breed)
Leishmania-infected macrophages (Beth)
 
Roses
Mycobacterium tuberculosis (gfp)-infected macrophages
Leishmania-infected macrophages (Beth)

NEWS!

- The work of David Russell's lab was featured in the Cronell Chronicle: Seeking to create better drugs, researchers chip away at how tuberculosis survives inside human defense cells (12/12/07).

- The work of Klaus Osterrieder's lab was featured in the Cornell Chronicle: Tiny chemical change in horse herpes virus can have lethal effect, Cornell researchers discover (11/8/07).

- The work of Daniel Klessig's lab was featured in the Cornell Chronicle: Elusive agent that triggers immune response in plants is finally uncovered by BTI researchers at Cornell (10/4/07).

- This year's retreat will be on April 4 - 5, at the Ramada Inn Lakefront Geneva, Geneva, NY. To see the details of the last year's program retreat (April 27 - 28 at at the Owego Treadway Inn & Conference Center, Owego, NY), click here.

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Introduction to the Program:

Pathologic changes occurring as a result of infection or exposure to toxic agents are common in both animals and plants. At Cornell University, scientists studying the interplay between host and pathogen/toxin have been brought together in a multidepartmental program entitled Infection and Pathobiology. The program spans the various disciplines involved and facilitates broader interactions between departments and graduate fields that share common interests in host-pathogen interactions.

 

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The Program's Mission:

The mission of this interdisciplinary program is to generate a graduate student and post-doctoral trainee community with common seminars and retreats that cross the boundaries between fields and departments.

 

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Membership of the Program:

The program represents interests in the following departments and graduate fields. These departments and fields have chosen to ally themselves with "Infection and Pathobiology" to increase interchange between their respective research communities. Specific information concerning these fields and departments can be accessed from the following links:

Graduate Fields

Departments

Microbiology and Immunology
(College of Veterinary Medicine)
Microbiology
(College of Agriculture and Life Sciences)
Plant Pathology
(College of Agriculture and Life Sciences)
Food Science
(College of Agriculture and Life Sciences)

Faculty Members

Dept. of Microbiology and Immunology

Douglas Antczak ( dfa1@cornell.edu ) (James Baker Institute)

Comparative studies of the Major Histocompatibility Complex, Fetal-maternal immunological interactions and trophoblast development, clinical immunology of infectious diseases in horses, gene mapping and genomic studies in equids.

Judy Appleton ( jaa2@cornell.edu ) (James Baker Institute)

Mucosal immunity in the intestinal tract, specifically intestinal immunity expressed against parasitic nematodes.

Joel Baines ( jdb11@cornell.edu )

Molecular biology and biochemistry of herpesvirus assembly, envelopment, and cellular exit. Herpesvirus neurovirulence. Cell biology of herpesvirus induced changes in cultured cells.

Stephen Bloom ( seb14@cornell.edu )

Drug and environmental toxin effect on the development of the immune and other systems.

Dwight Bowman ( ddb3@cornell.edu )

Soil transmitted parasites, parasites of wildlife, biosurveillance.

Paul Bowser ( prb4@cornell.edu )

Infectious and non-infectious diseases of fish, pathogenesis of retrovirus-caused tumors of fish, pathogenesis of rhabdoviral infections in fish, evaluation of new therapeutic compounds for use in cultured food fish.

Margaret Bynoe ( msb76@cornell.edu )

The molecular basis of antigen induced immune suppression and the modulation of the innate immune system response in immunity against cancer.

James Casey ( jwc3@cornell.edu )

Eukaryotic gene regulation, oncogenic transformation, viral replication, viral pathogenesis, toxicology.

Theodore Clark ( tgc3@cornell.edu )

Biology of the parasitic protist Ichthyophthirius multifilis (Ich), fish immunology, vaccine development.

Eric Denkers ( eyd1@cornell.edu )

Immunity to the intracellular protozoan parasite Toxoplasma gondii, with an emphasis on the role of neutrophils in the development of protective immune responses and on the ability of the parasite to inhibit intracellular signaling pathways that are key to the induction of protective cytokine gene expression.

Rodney Dietert ( rrd1@cornell.edu )

Environmental control of immunity and immunotoxilogical risk.

Jerrie Gavalchin ( jg234@cornell.edu )

Autoimmunity. The development of immunologic strategies to inhibit or prevent autoimmune responses and the effect of infection on the development of autoimmune conditions.

Matthias Hesse - ( mh325@cornell.edu )

Immune-mediated pathology in a mouse model of schistosomiasis.

Cynthia Leifer ( cal59@cornell.edu )

Understanding innate immunity from the inside out: Toll-like receptors, signaling, dendritic cells, and controlling microbial infection.

George Lust ( gl25@cornell.edu ) (James Baker Institute)

Genetics and pathogenesis of canine hip dysplasia and equine osteoarthritis. Molecular genetic markers.

Hélène Marquis ( hm72@cornell.edu )

Pathogenesis of Listeria monocytogenes, mechanisms of regulation of specific virulence factors.

Susana Mendez (sm457@cornell.edu) (James Baker Institute)

Immunology to parasitic diseases (protozoa and helminths), with especial interest in vaccine development and genetic susceptibility.

Klaus Osterrieder ( no34@cornell.edu )

Molecular pathogenesis and vaccinology of Equine Herpesvirus and Marek's Disease Virus.

John Parker ( jsp7@cornell.edu ) (James Baker Institute)

Cell biology, biochemistry and molecular biology of mammalian orthoreovirus-host cell interactions. Use of reoviruses as oncotherapeutic agents.

Colin Parrish ( crp3@cornell.edu )(James Baker Institute)

Structure and function of canine parvovirus, crystallography, virus assembly, mechanism of host cell invasion.

David Russell ( dgr8@cornell.edu )

The biology of intracellular infection, with emphasis on Mycobacteria.

Karel (Ton) Schat ( kas24@cornell.edu )

Avian tumor virology and immunology, molecular biology of Marek's disease virus and chicken infectious anemia virus, avian virology, avian immunology, avian intestinal virus infections and intestinal immunity.

Marci Scidmore ( ms299@cornell.edu )

The biology of intracellular infection by the Chlamydia bacterium.

Gary Whittaker ( grw7@cornell.edu )

Endocytosis of influenza virus, nuclear transport of influenza virus, role of protein M1 in assembly of the virus.

Dept. of Microbiology

Stephen Winans ( scw2@cornell.edu )

Detection by pathogens of host-released chemical signal molecules, cell-cell signalling in bacteria.

Joseph Peters ( jep48@cornell.edu )

Molecular mechanisms that facilitate the dissemination of mobile DNA elements encoding antibiotic resistance and other pathogenicity
determinants. Transposition as a tool for functional genomics.

Dept. of Plant Pathology

Samuel Cartinhour (sc167@cornell.edu)

Analysis and modeling of gene regulation in Pseudomonas syringae pv. tomato DC3000, with particular emphasis on subsystems relevant to pathogenesis.

Alan Collmer ( arc2@cornell.edu )

Explores the molecular basis of bacterial plant pathogenicity, with a focus on effector proteins, secretion pathways, and functional genomics of Pseudomonas syringae pv. tomato DC3000.

William Fry ( wef1@cornell.edu)

Investigates the basic biology and genetics of oomycete pathogens and their interactions with plant hosts. See the lab page at http://ppathw3.cals.cornell.edu/fr/index.htm.

Daniel Klessig ( dfk8@cornell.edu ) (Boyce Thompson Institute for Plant Research)

The major focus of his research is to help determine, at molecular and cellular levels, how plants protect themselves against microbial pathogens.

Sondra Gale Lazarowitz ( sgl5@cornell.edu )

Molecular genetics of plant virus movement and host resistance to virus infection; Nuclear shuttling and protein-membrane interactions.

Rosemary Loria ( rl21@cornell.edu )

Explores the evolution and molecular basis for plant pathogenicity in Gram-positive bacteria, with a focus on horizontal transfer and functional analysis of a pathogenicity island among Streptomyces species that cause economically important diseases of root and tuber crops.

Gregory B. Martin ( gbm7@cornell.edu ) (Plant Pathology/Boyce Thompson Institute)

Investigates molecular basis of plant disease resistance and susceptibility. Research in his laboratory focuses on understanding how plants recognize and defend themselves against pathogens.

Keith Perry ( klp3@cornell.edu )

Vector transmission of plant viruses, structure of cucumber mosaic virus, plant pathogen detection, disease-free foundation potato seed production.

Dept. of Food Science 

Kathryn Boor ( kjb4@cornell.edu )

Research interests focus on the pathogenesis of foodborne diseases and particularly on links between bacterial stress response systems and virulence and regulation of gene expression during infection. A specific research focus is on the althernative sigma factor sigma B and gene expression in the foodborne pathogen L. monocytogenes.

Martin Wiedmann ( mw16@cornell.edu )

Research interests focus on pathogenesis, evolution, molecular ecology and epidemiology of foodborne and zoonotic pathogens. On-going research focuses on Listeria monocytogenes and molecular basis of host specificity in zoonotic pathogens.

Other Departments

Craig Altier (ca223@cornell.edu) (Dept. of Population Medicine and Diagnostic Sciences)

Pathogenesis of Salmonella, regulation of virulence.

Gary Blissard (gwb1@cornell.edu) (Boyce Thompson Institute for Plant Research)

Structure and function of baculovirus envelope proteins and their roles in viral entry into host cells, and exit by virion budding. Genetics and molecular biology of baculovirus gene expression.

Elizabeth Buckles (elb36@cornell.edu) (Dept. of Biomedical Sciences)

Molecular pathogenesis of avian viruses and effects of disease on wild animal populations.

Yung-Fu Chang (yc42@cornell.edu) (Dept. of Population Medicine and Diagnostic Sciences)

The molecular biology of bacterial pathogens of veterinary and zoonotic importance, vaccine development, and immunopathogenesis of Lyme arthritis and ehrlichiosis.

Ruth Collins (rnc8@cornell.edu) (Dept. of Molecular Medicine)

Functions and analysis of Rab GTPases; polarized growth and exocytosis; post-translational modifications of proteins regulating intracellular traffic; YIP1 proteins.

Matthew DeLisa (md255@cornell.edu) (Dept. of Chemical and Biomolecular Engineering)

Molecular mechanisms that facilitate protein secretion of virulence determinants in bacteria.

Julia Flaminio (mbf6@cornell.edu) (Dept. of Clinical Science)

Cellular and molecular mechanisms involved in B cell response; neonatal immunology and response to vaccination; immunomodulation using biologic response modifiers; cancer immunotherapy; characterization of primary and secondary immunodeficiency.

Laura Harrington (lch27@cornell.edu) (Dept. of Entomology)

Ecology and behavior of disease vectors, epidemiology, and arbovirus transmission dynamics.

Maria J. Harrison (mjh78@cornell.edu) (Boyce Thompson Institute for Plant Research)

The arbuscular mycorrhizal symbiosis. Genetic and genomics approaches are used to investigate the molecular basis of the symbiotic associations formed by plants and arbuscular mycorrhizal fungi.

David Holowka (dah24@cornell.edu) (Dept. of Chemistry and Chemical Biology)

Molecular basis and cell biology of immunoreceptor signaling; roles for specific lipids and membrane structure in signal transduction and trafficking processes.

Stephan Menne (sm119@cornell.edu) (Dept. of Clinical Sciences)

Pathogenesis of woodchuck hepatitis virus in woodchucks as a model for chronic infection with the hepatitis B virus in humans, with a focus on innate and adaptive cell-mediated immunology, vaccinology, immunotherapy, and antiviral therapy with third generation nucleoside analogs.

Peter Moffett (pm99@cornell.edu) (Boyce Thompson Institute for Plant Research)

Plant disease resistance genes. Molecular mechanisms of defense against pathogens using model plant-virus interactions.

Donald H. Schlafer (dhs2@cornell.edu) (Dept. of Biomedical Sciences)

Infectious diseases of domestic animal (From the perspective of Diagnostic Pathology ; Foreign Animal Diseases (research - African Swine Fever); Enteric viral Diseases; Pathophysiology of Infectious Disease involving reproduction - focusing of abortifacient diseases.

Kenneth Simpson (kws5@cornell.edu) (Dept. of Clinical Sciences)

Pathogenesis, immunology, and zoonotic transmission of Helicobacter infection.

Bettina Wagner ( bw73@cornell.edu ) (Dept. of Population Medicine and Diagnostic Sciences)

Allergy and development of allergy predisposition in horses, Comparative analysis of immune system genes in veterinary species, Development of new tools for diagnosis of infectious diseases and immunological research in animals.

Related Programs  

Some of our faculty members also participate in the Program in Virology.

The Graduate Fields of Comparative Biomedical Sciences, Immunology and Microbiology also participates in the Graduate Program in Biological and Biomedical Sciences.

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Organizing Committee Members:

Stephen Bloom (Dept. of Microbiology and Immunology), seb14@cornell.edu

Alan Collmer (Dept. of Plant Pathology), arc2@cornell.edu

Colin Parrish (Dept. of Microbiology and Immunology/Baker Institute), crp3@cornell.edu

David Russell (Dept. of Microbiology and Immunology), dgr8@cornell.edu

Martin Wiedmann (Dept. of Food Science), mw16@cornell.edu

Stephen Winans (Dept. of Microbiology), scw2@cornell.edu

Laura Goodman (Graduate Student, Dept. of Microbiology & Immunology), llb27@cornell.edu

Karla Stucker (Graduate Student, Dept. of Microbiology & Immunology/Baker Institute), kms36@cornell.edu

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Program Events:

Seminar Series

Seminars in Infection & Immunity - Spring 2008, Fall 2008

There are also seminar series offered by different departments:

Scientific Writing Workshops

Supervisory Training Sessions for Graduate Students and Postdocs

Spring 2001
Thursday, Jan. 31: Supervisory Responsibility & Acceptable Conduct in the Workplace.
Thursday, Feb. 14: Conflict Resolution & Handling Emotions at Work
Tuesday, Feb. 26: Giving & Receiving Constructive Feedback & Handling Discipline Effectively.

All sessions were from 12:30 - 2:00 in C5 129, VMC, lunches served.

Retreat

Retreat 2008: April 4 - 5, at the Ramada Inn Lakefront Geneva, Geneva, NY.

Keynote Speaker:
Dr. Robert W. Doms, M.D., Ph.D.
Chair, Department of Microbiology, University of Pennsylvania
http://www.med.upenn.edu/micro/faculty/doms.html

Retreat 2007: April 27 - 28, at the Owego Treadway Inn, Owego, NY.

Keynote Speaker:
Dr. Luke Alphey
Professor, Dept. of Zoology, Oxford University, UK /
Rsearch Director, Oxitech Ltd., Oxford, UK

To see the retreat program, click here (PDF file)

 

Last year's retreat featured student and postdoctoral speakers that reflected wide range of research fields, and a keynote speaker from outside Cornell. All the participants of the program were invited, and the room/meal cost was provided by the program. It was a very successful retreat with about 110 attendees from all the participating fields/departments of the program (photos: during dinner, 2007)

Retreat 2006: April 21 - 22, at the Canandaigua In on the Lake, Canandaigua, NY.

Retreat 2005: April 29 - 30, at the Owego Treadway Inn, Owego, NY.

Retreat 2004: April 23 - 24, at the Holiday Inn Waterloo-Seneca Falls.

• Retreat 2003: April 18 - 19, at the Canandaigua Inn On The Lake, Canandaigua, NY.

• Retreat 2002: April 26 - 27, at the Ramada Inn Geneva Lakefront, NY

 

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If you are interested...

If you are a prospective student, please e-mail to <sf35@cornell.edu> including the requested information below, or call or write to Ms. Sachiko Funaba, Administrative Assistant, Dept. of Microbiology & Immunology, C5 173 VMC, Cornell University, Ithaca, NY 14853. Telephone: (607) 253-3402.

First/Given Name
Last/Family Name
E-mail Address
Grauduate Field of Interest - choose from:
          Comparative Biomedical Sciences; Immunology; Microbiology;
          Food Science; Plant Pathology; Environmantal Toxicology;
          Undecided
Degree(s) held/Institution 
Comments/Questions 

If you are a Cornell member and interested in joining the program, please e-mail to <sf35@cornell.edu> indicating your interest. If you have any questions, please contact Sachiko at the above address.

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Microbiology and Immunology/Microbiology/Plant Pathology/Food Science

 

 

© Cornell University College of Veterinary Medicine

Questions or Comments? E-mail to sf35@cornell.edu
Last updated on January 17, 2008