Professor of Biomedical Science 

 
Ph.D.,1985 Anatomy
School of Medicine, University of Wisconsin
Madison, Wisconsin

D.V.M.,1980
University of Minnesota
Saint Paul, Minnesota

B.A., 1964, Biology
Stamford University

EXPLORE MY LAB TEACHING RECENT PUBLICATIONS

Research Interests

My long term research objective is to understand fundamental control mechanisms at different levels of skeletal integration-from the molecular to the cellular to that of the individual-that are responsible for co-ordinated long bone growth. This objective includes the understanding of perturbations of normal growth, with the intent of understanding the possiblities and limitations of intervention procedures for the correction of abnormalities of long bone growth. I divide this research into two
major themes:
1)analysis of chondrocytic control of diffrential bone growth in the postnatal animal; and
2) analysis of altered growth plate activity during naturally occuring and experimentally induced perturbations of growth, including spontaneous disease. Particularly important in my most recent research is the analysis of a variety of transgenic and knockout mutants that have specific perturbations leading to abnormal growth plate activity.

Major current collaborations include:

1) analysis of radiation-induced damage to rat growth plates as a model to study radiation effects and possible treatments of bone tumors with Drs. Tim Damron and Joseph Spadaro at SUNY Upstate Medicial University.

2) a study of mechanical modulation of growth plate activity as a model of scoliosis in children with Dr. Ian Stokes at the University of Vermont.

3) a study of the vascular environment of the growth plate using multi-phonton microscopy.  This study is in collaboration with Drs. Rebecca Williams and Warren Zipfel  ( DRBIO Research Group ) at Cornell University, using transgenic mice with GFP-linked to the collagen II promoter genes.  These mice were generously given to us by 
Dr. Bill Horton, Director of the Research Center of Shriner's Hospital in Portland, OR.
 

"Color-stained rat proximal tibia growth plates."

Graduate Field Memberships:

Veterinary Medicine, Zoology, and Biomedical Engineering (Affiliate member)

updated: 11/3/99

Back to the Graduate Field of Zoology