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The Immobilization Antigenes of Ichthyophthirius:
From Genes to Vaccines
Dr. Harry Dickerson
Abstract
NON-TECHNICAL SUMMARY: The parasite Ichthyophthirius multifiliis is the causative agent of "white-spot" disease and is among the most significant protozoan pathogens of farm-raised fishes. The purpose of this study is to develop an easily administered and effective vaccine that will protect fishes against infection with I. multifiliis.
OBJECTIVES: Express i-antigen genes of Ichthyophthirius multifiliis serotypes A and D in the free-living ciliate Tetrahymena thermophila, and test the products as mono-and polyvalent vaccines in channel catfish by intraperitoneal injection. Attempt to induce immunity in channel catfish by bath immunization using secreted i-antigens produced by the live T. theromophila vaccine vector.
PERFORMING INSTITUTION:
COLLEGE OF VET MEDICINE
UNIVERSITY OF GEORGIA
110 RIVERBEND ROAD
ATHENS, GEORGIA 30602
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