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Principal Investigator: Dr. Yrjö Gröhn, Dr. Ynte Schukken, Dr. Susan Stehman
Contact Information: E-mail:ytg1@cornell.edu - Phone: 607-253-3571
Sponsor: USDA University of Minnesota
Grant Number: 2004-35605-14243
Title: JDIP: Johne's Disease Integrated Program in Research, Education, and Extension
Annual Direct Cost: $130,820
Project Period: 04/15/04-04/14/05
Johne's disease is a disease which results in lost productivity in dairy herds and potential morbidity/mortality. There is also some concern that the bacterium itself is related to the onset of Crohn's disease in humans. The JDIP program aims to control, and potentially eliminate, Johne's through a combination of research projects on how to manage the disease, and potentially eliminate it. This is being done through a broad collaboration of research universities and USDA groups, with the collaboration and support of the impacted private sector.
Objectives: To establish an integrated program in Johne's disease research with a focus on developing a strong translational pipeline of new diagnostic tests, vaccine candidates and strategies to manage, prevent and control the disease.
Approach: The above noted objectives will be accomplished via thematic research units on: Johne's disease epidemiology; diagnostic test development including strain differentiation; M. paratuberculosis basic biology and pathogenesis; and strategies for enhancing T and B cell immune response to M. paratuberculosis. These research units will be supported by scientific support cores in: Biostatics and Epidemiology; Diagnostics and Strain Differentiation; Gene and Protein Expression; and Animal Experimentation. In addition, an Administrative Core will provide support for both research units and the scientific cores while a Communications and Extension Core will facilitate communication within the overall JDIP as well as translating the outcomes from the research into educational information for the broadly affected Johne's community. An external advisory board, chosen from public and private stakeholder, will provide guidance to the JDIP team in pursuit of the overall objectives.
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